Design of new potent and selective secretory phospholipase A(2) inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives
Meddad-Belhabich, Nadia, Aoun, Darina, Djimdé, Atimé, Redeuilh, Catherine, Dive, Georges, Massicot, France, Chau, François, Heymans, Françoise, Lamouri, Aazdine
Published in Bioorganic & medicinal chemistry (15.05.2010)
Published in Bioorganic & medicinal chemistry (15.05.2010)
Get full text
Journal Article
Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity
Serradji, Nawal, Bensaid, Okkacha, Martin, Marc, Sallem, Wafa, Dereuddre-Bosquet, Nathalie, Benmehdi, Houcine, Redeuilh, Catherine, Lamouri, Aazdine, Dive, Georges, Clayette, Pascal, Heymans, Françoise
Year of Publication 01.12.2006
Year of Publication 01.12.2006
Get full text
Web Resource
Structure–activity relationships in platelet-activating factor. Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity
Serradji, Nawal, Bensaid, Okkacha, Martin, Marc, Sallem, Wafa, Dereuddre-Bosquet, Nathalie, Benmehdi, Houcine, Redeuilh, Catherine, Lamouri, Aazdine, Dive, Georges, Clayette, Pascal, Heymans, Françoise
Published in Bioorganic & medicinal chemistry (01.12.2006)
Published in Bioorganic & medicinal chemistry (01.12.2006)
Get full text
Journal Article
Inhibition of Secreted Phospholipase A2. 4-Glycerol Derivatives of 4,5-Dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with Broad Activities
Touaibia, Mohamed, Djimdé, Atimé, Cao, Fei, Boilard, Eric, Bezzine, Sofiane, Lambeau, Gérard, Redeuilh, Catherine, Lamouri, Aazdine, Massicot, France, Chau, François, Dong, Chang-Zhi, Heymans, Françoise
Published in Journal of medicinal chemistry (05.04.2007)
Published in Journal of medicinal chemistry (05.04.2007)
Get full text
Journal Article
Inhibition of secretory phospholipase A2. 2-Synthesis and structure-activity relationship studies of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one (PMS1062) derivatives specific for group II enzyme
DONG, Chang-Zhi, AHAMADA-HIMIDI, Azali, MASSICOT, France, HEYMANS, Francoise, PLOCKI, Stephanie, AOUN, Darina, TOUAIBIA, Mohamed, MEDDAD-BEL HABICH, Nadia, HUET, Jack, REDEUILH, Catherine, OMBETTA, Jean-Edouard, GODFROID, Jean-Jacques
Published in Bioorganic & medicinal chemistry (15.03.2005)
Published in Bioorganic & medicinal chemistry (15.03.2005)
Get full text
Journal Article
Differential effect of PMS777, a new type of acetylcholinesterase inhibitor, and galanthamine on oxidative injury induced in human neuroblastoma SK-N-SH cells
Ezoulin, Miezan J.-M., Li, Juan, Wu, Guirong, Dong, Chang-Zhi, Ombetta, Jean-Edouard, Chen, Hong-Zhuan, Massicot, France, Heymans, Françoise
Published in Neuroscience letters (02.12.2005)
Published in Neuroscience letters (02.12.2005)
Get full text
Journal Article
Structure−Activity Relationships in Platelet-Activating Factor. 12. Synthesis and Biological Evaluation of Platelet-Activating Factor Antagonists with Anti-HIV-1 Activity
Serradji, Nawal, Martin, Marc, Bensaid, Okkacha, Cisternino, Salvatore, Rousselle, Christophe, Dereuddre-Bosquet, Nathalie, Huet, Jack, Redeuilh, Catherine, Lamouri, Aazdine, Dong, Chang-Zhi, Clayette, Pascal, Scherrmann, Jean-Michel, Dormont, Dominique, Heymans, Françoise
Published in Journal of medicinal chemistry (02.12.2004)
Published in Journal of medicinal chemistry (02.12.2004)
Get full text
Journal Article
Inhibition of secretory phospholipase A2. 1-Design, synthesis and structure-activity relationship studies starting from 4-tetradecyloxybenzamidine to obtain specific inhibitors of group II sPLA2s
ASSOGBA, Léon, AHAMADA-HIMIDI, Azali, GODFROID, Jean-Jacques, DONG, Chang-Zhi, HEYMANS, Francoise, HABICH, Nadia Meddad-Bel, AOUN, Darina, BOUKLI, Latifa, MASSICOT, France, MOUNIER, Carine M, HUET, Jack, LAMOURI, Aazdine, OMBETTA, Jean-Edouard
Published in European journal of medicinal chemistry (01.09.2005)
Get full text
Published in European journal of medicinal chemistry (01.09.2005)
Journal Article
Structure-activity relationships in platelet-activating factor (PAF). 11-From PAF-antagonism to phospholipase A2 inhibition: syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines
BINISTI, Carine, ASSOGBA, Léon, TOUBOUL, Estéra, MOUNIER, Carine, HUET, Jack, OMBETTA, Jean-Edouard, CHANG ZHI DONG, REDEUILH, Catherine, HEYMANS, Francoise, GODFROID, Jean-Jacques
Published in European journal of medicinal chemistry (01.10.2001)
Published in European journal of medicinal chemistry (01.10.2001)
Get full text
Journal Article
Structure–activity relationships in platelet-activating factor. Part 14: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity
Sallem, Wafa, Serradji, Nawal, Dereuddre-Bosquet, Nathalie, Dive, Georges, Clayette, Pascal, Heymans, Françoise
Published in Bioorganic & medicinal chemistry (01.12.2006)
Published in Bioorganic & medicinal chemistry (01.12.2006)
Get full text
Journal Article
Web Resource
Protection of PMS777, a New AChE Inhibitor with PAF Antagonism, Against Amyloid-β-Induced Neuronal Apoptosis and Neuroinflammation
Li, Juan, Hu, Jinjia, Shao, Biyun, Zhou, Wei, Cui, Yongyao, Dong, Changzhi, Ezoulin, Jean-Marc Miezan, Zhu, Xu, Ding, Wenlong, Heymans, Françoise, Chen, Hongzhuan
Published in Cellular and molecular neurobiology (01.06.2009)
Published in Cellular and molecular neurobiology (01.06.2009)
Get full text
Journal Article
Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice
Miezan Ezoulin, Jean Marc, Shao, Bi-yun, Xia, Zheng, Xie, Qiong, Li, Juan, Cui, Yong-yao, Wang, Hao, Dong, Chang-zhi, Zhao, Yan-xing, Massicot, France, Qiu, Zhui-bai, Heymans, Françoise, Chen, Hong-zhuan
Published in The international journal of neuropsychopharmacology (01.11.2009)
Published in The international journal of neuropsychopharmacology (01.11.2009)
Get full text
Journal Article
Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity
Li, Juan, Huang, Hong, Miezan Ezoulin, Jean-Marc, Gao, Xiao-Ling, Massicot, France, Dong, Chang-Zhi, Heymans, Françoise, Chen, Hong-Zhuan
Published in The international journal of neuropsychopharmacology (01.02.2007)
Published in The international journal of neuropsychopharmacology (01.02.2007)
Get full text
Journal Article
Design of Group IIA Secreted/Synovial Phospholipase A2 Inhibitors: An Oxadiazolone Derivative Suppresses Chondrocyte Prostaglandin E2 Secretion
Ombetta, Jean-Edouard, Thelier, Natacha, Dong, Chang Zhi, Plocki, Stéphanie, Tsagris, Lydia, Rannou, François, Massicot, France, Djimdé, Atimé, El-Hayek, Elissar, Shi, Yiming, Heymans, Françoise, Gresh, Nohad, Chauvet, Caroline
Published in PloS one (01.06.2010)
Published in PloS one (01.06.2010)
Get full text
Journal Article
Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3',4',5'-trimethoxybenzoyl)-2-[[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines
Lamouri, Aazdine, Heymans, Francoise, Tavet, Fabrice, Dive, Georges, Batt, Jean Pierre, Blavet, Nicole, Braquet, Pierre, Godfroid, Jean Jacques
Published in Journal of medicinal chemistry (16.04.1993)
Published in Journal of medicinal chemistry (16.04.1993)
Get full text
Journal Article
PMS777, A Bis-interacting Ligand for PAF Receptor Antagonism and AChE Inhibition, Attenuates PAF-induced Neurocytotoxicity in SH-SY5Y Cells
Li, Juan, Shao, Biyun, Zhu, Liang, Cui, Yongyao, Dong, Changzhi, Miezan Ezoulin, Jean-Marc, Gao, Xiaoling, Ren, Qiushi, Heymans, Françoise, Chen, Hongzhuan
Published in Cellular and molecular neurobiology (2008)
Published in Cellular and molecular neurobiology (2008)
Get full text
Journal Article
Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders
Eggert, Dawn, Dash, Prasanta K, Serradji, Nawal, Dong, Chang-Zhi, Clayette, Pascal, Heymans, Francoise, Dou, Huanyu, Gorantla, Santhi, Gelbard, Harris A, Poluektova, Larisa, Gendelman, Howard E
Published in Journal of neuroimmunology (18.08.2009)
Published in Journal of neuroimmunology (18.08.2009)
Get full text
Journal Article
Inhibition of secreted phospholipase A(2)center dot 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities
Touaibia, Mohamed, Djimde, Atime, Cao, Fei, Boilard, Eric, Bezzine, Sofiane, Lambeau, Gerard, Redeuilh, Catherine, Lamouri, Aazdine, Massicot, France, Chau, Francois, Dong, Chang-Zhi, Heymans, Francoise
Published in Journal of medicinal chemistry (05.04.2007)
Published in Journal of medicinal chemistry (05.04.2007)
Get full text
Journal Article
Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion
Ombetta, Jean-Edouard, Thelier, Natacha, Dong, Chang Zhi, Plocki, Stéphanie, Tsagris, Lydia, Rannou, François, Massicot, France, Djimdé, Atimé, El-Hayek, Elissar, Shi, Yiming, Heymans, Françoise, Gresh, Nohad, Chauvet, Caroline
Published in PloS one (01.06.2010)
Published in PloS one (01.06.2010)
Get full text
Journal Article
Protection of PMS777, a New AChE Inhibitor with PAF Antagonism, Against Amyloid-b-Induced Neuronal Apoptosis and Neuroinflammation
Li, Juan, Hu, Jinjia, Shao, Biyun, Zhou, Wei, Cui, Yongyao, Dong, Changzhi, Ezoulin, Jean-Marc Miezan, Zhu, Xu, Ding, Wenlong, Heymans, Francoise, Chen, Hongzhuan
Published in Cellular and molecular neurobiology (01.06.2009)
Published in Cellular and molecular neurobiology (01.06.2009)
Get full text
Journal Article