Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine
Muramatsu, Hiromi, Lam, Kieu, Bajusz, Csaba, Laczkó, Dorottya, Karikó, Katalin, Schreiner, Petra, Martin, Alan, Lutwyche, Peter, Heyes, James, Pardi, Norbert
Published in Molecular therapy (04.05.2022)
Published in Molecular therapy (04.05.2022)
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Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)
Parhiz, Hamideh, Brenner, Jacob S., Patel, Priyal N., Papp, Tyler E., Shahnawaz, Hamna, Li, Qin, Shi, Ruiqi, Zamora, Marco E., Yadegari, Amir, Marcos-Contreras, Oscar A., Natesan, Ambika, Pardi, Norbert, Shuvaev, Vladimir V., Kiseleva, Raisa, Myerson, Jacob W., Uhler, Thomas, Riley, Rachel S., Han, Xuexiang, Mitchell, Michael J., Lam, Kieu, Heyes, James, Weissman, Drew, Muzykantov, Vladimir R.
Published in Journal of controlled release (01.04.2022)
Published in Journal of controlled release (01.04.2022)
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Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids
Heyes, James, Palmer, Lorne, Bremner, Kaz, MacLachlan, Ian
Published in Journal of controlled release (03.10.2005)
Published in Journal of controlled release (03.10.2005)
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Immunogenicity and protective efficacy of SARS-CoV-2 mRNA vaccine encoding secreted non-stabilized spike in female mice
Prompetchara, Eakachai, Ketloy, Chutitorn, Alameh, Mohamad-Gabriel, Tharakhet, Kittipan, Kaewpang, Papatsara, Yostrerat, Nongnaphat, Pitakpolrat, Patrawadee, Buranapraditkun, Supranee, Manopwisedjaroen, Suwimon, Thitithanyanont, Arunee, Jongkaewwattana, Anan, Hunsawong, Taweewan, Im-Erbsin, Rawiwan, Reed, Matthew, Wijagkanalan, Wassana, Patarakul, Kanitha, Techawiwattanaboon, Teerasit, Palaga, Tanapat, Lam, Kieu, Heyes, James, Weissman, Drew, Ruxrungtham, Kiat
Published in Nature communications (21.04.2023)
Published in Nature communications (21.04.2023)
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Can Machine Learning Create an Advocate for Foster Youth?
Brindley, Meredith, Heyes, James P., Booker, Darrell
Published in Journal of technology in human services (02.01.2018)
Published in Journal of technology in human services (02.01.2018)
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ASL mRNA-LNP Therapeutic for the Treatment of Argininosuccinic Aciduria Enables Survival Benefit in a Mouse Model
Daly, Owen, Mahiny, Azita Josefine, Majeski, Sara, McClintock, Kevin, Reichert, Julia, Boros, Gábor, Szabó, Gábor Tamás, Reinholz, Jonas, Schreiner, Petra, Reid, Steve, Lam, Kieu, Lepper, Marlen, Adler, Melanie, Meffen, Tracy, Heyes, James, Karikó, Katalin, Lutwyche, Pete, Vlatkovic, Irena
Published in Biomedicines (01.06.2023)
Published in Biomedicines (01.06.2023)
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Lipid Encapsulation Enables the Effective Systemic Delivery of Polyplex Plasmid DNA
Heyes, James, Palmer, Lorne, Chan, Kitty, Giesbrecht, Cory, Jeffs, Lloyd, MacLachlan, Ian
Published in Molecular therapy (01.04.2007)
Published in Molecular therapy (01.04.2007)
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The prehospital patient pathway and experience of care with acute heart failure: a comparison of two health care systems
McCambridge, Joseph, Keane, Ciara, Walshe, Myra, Campbell, Patricia, Heyes, James, Kalra, Paul R., Cowie, Martin R., Riley, Jillian P., O'Hanlon, Rory, Ledwidge, Mark, Gallagher, Joseph, McDonald, Kenneth
Published in ESC Heart Failure (01.04.2021)
Published in ESC Heart Failure (01.04.2021)
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Structure-Activity Relationship in Cationic Lipid Mediated Gene Transfection
Niculescu-Duvaz, Dan, Heyes, James, Springer, Caroline
Published in Current medicinal chemistry (01.07.2003)
Published in Current medicinal chemistry (01.07.2003)
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RNAi-mediated gene silencing in non-human primates
Wheat, Amanda J, Vornlocher, Hans-Peter, Röhl, Ingo, Lam, Kieu, McClintock, Kevin, Koteliansky, Victor, Yaworski, Ed, Jeffs, Lloyd B, MacLachlan, Ian, Soutschek, Jürgen, Toudjarska, Ivanka, Palmer, Lorne R, Heyes, James A, Zedalis, William, Akinc, Akin, Lee, Amy C. H, Bumcrot, David, Manoharan, Muthiah, Judge, Adam D, Racie, Timothy, Shanmugam, Sumi, Sood, Vandana, Seiffert, Stephan, Bramlage, Birgit, Fedoruk, Matthew N, Harborth, Jens, Zimmermann, Tracy S, John, Matthias, Nechev, Lubomir V
Published in Nature (04.05.2006)
Published in Nature (04.05.2006)
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Optimizing Lipid Nanoparticles for Delivery in Primates
Lam, Kieu, Schreiner, Petra, Leung, Ada, Stainton, Paul, Reid, Steve, Yaworski, Ed, Lutwyche, Pete, Heyes, James
Published in Advanced materials (Weinheim) (01.06.2023)
Published in Advanced materials (Weinheim) (01.06.2023)
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Journal Article
Unsaturated, Trialkyl Ionizable Lipids are Versatile Lipid‐Nanoparticle Components for Therapeutic and Vaccine Applications
Lam, Kieu, Leung, Ada, Martin, Alan, Wood, Mark, Schreiner, Petra, Palmer, Lorne, Daly, Owen, Zhao, Wenchen, McClintock, Kevin, Heyes, James
Published in Advanced materials (Weinheim) (01.04.2023)
Published in Advanced materials (Weinheim) (01.04.2023)
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Journal Article
Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance
Holland, Richard, Lam, Kieu, Jeng, Sunny, McClintock, Kevin, Palmer, Lorne, Schreiner, Petra, Wood, Mark, Zhao, Wenchen, Heyes, James
Published in ACS nano (16.04.2024)
Published in ACS nano (16.04.2024)
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Combination treatment of mannose and GalNAc conjugated small interfering RNA protects against lethal Marburg virus infection
Ye, Xin, Holland, Richard, Wood, Mark, Pasetka, Chris, Palmer, Lorne, Samaridou, Eleni, McClintock, Kevin, Borisevich, Viktoriya, Geisbert, Thomas W., Cross, Robert W., Heyes, James
Published in Molecular therapy (04.01.2023)
Published in Molecular therapy (04.01.2023)
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Journal Article
Combination treatment of mannose and GalNAc conjugated small interfering RNA protects against lethal Marburg virus infection
Ye, Xin, Holland, Richard, Wood, Mark, Pasetka, Chris, Palmer, Lorne, Samaridou, Eleni, McClintock, Kevin, Borisevich, Viktoriya, Geisbert, Thomas W., Cross, Robert W., Heyes, James
Published in Molecular therapy (01.03.2023)
Published in Molecular therapy (01.03.2023)
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