Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression
Ventura, Richard, Mordec, Kasia, Waszczuk, Joanna, Wang, Zhaoti, Lai, Julie, Fridlib, Marina, Buckley, Douglas, Kemble, George, Heuer, Timothy S.
Published in EBioMedicine (01.08.2015)
Published in EBioMedicine (01.08.2015)
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FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression
Heuer, Timothy S., Ventura, Richard, Mordec, Kasia, Lai, Julie, Fridlib, Marina, Buckley, Douglas, Kemble, George
Published in EBioMedicine (01.02.2017)
Published in EBioMedicine (01.02.2017)
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Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer
Zaytseva, Yekaterina Y, Rychahou, Piotr G, Le, Anh-Thu, Scott, Timothy L, Flight, Robert M, Kim, Ji Tae, Harris, Jennifer, Liu, Jinpeng, Wang, Chi, Morris, Andrew J, Sivakumaran, Theru A, Fan, Teresa, Moseley, Hunter, Gao, Tianyan, Lee, Eun Y, Weiss, Heidi L, Heuer, Timothy S, Kemble, George, Evers, Mark
Published in Oncotarget (15.05.2018)
Published in Oncotarget (15.05.2018)
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EXEL-7647 Inhibits Mutant Forms of ErbB2 Associated with Lapatinib Resistance and Neoplastic Transformation
TROWE, Torsten, BOUKOUVALA, Sotiria, VYSOTSKAIA, Valentina, JING PING YANG, GERRITSEN, Mary E, MATTHEWS, David J, LAMB, Peter, HEUER, Timothy S, CALKINS, Keith, CUTLER, Richard E, FONG, Ryan, FUNKE, Roel, GENDREAU, Steven B, KIM, Yong D, MILLER, Nicole, WOOLFREY, John R
Published in Clinical cancer research (15.04.2008)
Published in Clinical cancer research (15.04.2008)
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A Genome-Wide Analysis of Immune Responses in Drosophila
Irving, Phil, Troxler, Laurent, Heuer, Timothy S., Belvin, Marcia, Kopczynski, Casey, Reichhart, Jean-Marc, Hoffmann, Jules A., Hetru, Charles
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2001)
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Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90
Bussenius, Joerg, Blazey, Charles M., Aay, Naing, Anand, Neel K., Arcalas, Arlyn, Baik, TaeGon, Bowles, Owen J., Buhr, Chris A., Costanzo, Simona, Curtis, Jeffrey K., DeFina, Steven C., Dubenko, Larisa, Heuer, Timothy S., Huang, Ping, Jaeger, Christopher, Joshi, Anagha, Kennedy, Abigail R., Kim, Angie I., Lara, Katherine, Lee, Jae, Li, Jonathan, Lougheed, Julie C., Ma, Sunghoon, Malek, Shiva, Manalo, Jean-Claire L., Martini, Jean-Francois, McGrath, Garth, Nicoll, Monique, Nuss, John M., Pack, Michael, Peto, Csaba J., Tsang, Tsze H., Wang, Longcheng, Womble, Scott W., Yakes, Michael, Zhang, Wentao, Rice, Kenneth D.
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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Journal Article
Fatty acid synthase - Modern tumor cell biology insights into a classical oncology target
Buckley, Douglas, Duke, Gregory, Heuer, Timothy S, O'Farrell, Marie, Wagman, Allan S, McCulloch, William, Kemble, George
Published in Pharmacology & therapeutics (Oxford) (01.09.2017)
Published in Pharmacology & therapeutics (Oxford) (01.09.2017)
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Abstract 4743: Preclinical studies characterize tumor type sensitivity to FASN inhibition and the mechanism and efficacy of novel drug combinations with TVB-2640
Heuer, Timothy S., Ventura, Richard, Lai, Julie, Waszczuk, Joanna, Rubio, Claudia, Hammonds, Glenn, O’ Farrell, Marie, Buckley, Douglas, Kemble, George
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract LB-110: Computational discovery and preclinical validation of therapeutic leads with novel MOAs for hepatocellular carcinoma and pancreatic ductal adenocarcinoma
Hakim, Isaac, Chua, Mei-Sze, Wei, Wei, Ma, Li, Noblin, Elizabeth, So, Samuel, Daugherty, Aaron C., Heuer, Timothy S.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 2675: Biomarker and PK/PD analyses of first in class FASN inhibitor TVB-2640 in a first-in-human phase 1 study in solid tumor patients
O'Farrell, Marie, Crowley, Richard, Heuer, Timothy S., Buckley, Doug, Rubino, Chris M., McCulloch, William, Kemble, George
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 1010: Evaluation of small-molecule FASN inhibitors in preclinical models of colorectal cancer
Zaytseva, Yekaterina Y., Rychahou, Piotr G., Gao, Tianyan, Lee, Eun Y., Weiss, Heidi L., Heuer, Timothy S., Kemble, George, Evers, B. Mark
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract C175: FASN inhibition studies in preclinical tumor models identify biomarkers that align with in vitro and in vivo sensitivity to TVB-2640
Heuer, Timothy S., Ventura, Richard, Mordec, Kasia, Lai, Julie, Waszczuk, Joanna, Rubio, Claudia, O' Farrell, Marie, Buckley, Douglas, Kemble, George
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Abstract 4446: Discovery of tumor types highly susceptible to FASN inhibition and biomarker candidates for clinical analysis
Heuer, Timothy S., Ventura, Richard, Mordec, Kasia, Lai, Julie, Waszczuk, Joanna, Hammonds, Glenn, Fridlib, Marina, Johnson, Russell, Hu, Lily, Wagman, Allan, O'Farrell, Marie, Buckley, Douglas, Kemble, George
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 452: Activation of Akt pathway and autophagy promotes resistance to FASN inhibition in colorectal cancer patient-derived xenograft models
Zaytseva, Yekaterina Y., Rychahou, Piotr G., Le, Anh-Thu, Flight, Robert M., Scott, Timothy L., Harris, Jennifer W., Hodges, Sally, Hallahan, Brent J., Napier, Dana L., Liu, Jinpeng, Wang, Chi, Sunkara, Manjula, Morris, Andrew, Kim, Ji Tae, Arumugam, Sivakumaran Theru, Lane, Andrew, Fan, Teresa W., Moseley, Hunter, Gao, Tianyan, Lee, Eun Y., Weiss, Heidi L., Heuer, Timothy S., Kemble, George, Evers, B Mark
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 1815: Efficacy of FASN-selective small molecule inhibitors in preclinical tumor models
Heuer, Timothy S., Ventura, Richard, Waszczuk, Joanna, Mordec, Kasia, Lai, Julie, Johnson, Russell, Hu, Lilly, Cai, Haiying, Wagman, Allan, Buckley, Douglas, Parish, Stanley T., Bruckheimer, Elizabeth, Kemble, George
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Abstract B261: Characterization of FASN-selective small-molecule inhibitors in preclinical tumor models
Heuer, Timothy S., Chen, Minchao, Ventura, Richard, Waszczuk, Joanna, Yendluri, Satya, Lai, Julie, Tep, Samnang, Feng, Shirley, Johnson, Russell, Zaharia, Cristiana, Buckley, Douglas, Kemble, George
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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