Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma
Weinhold, Niels, Ashby, Cody, Rasche, Leo, Chavan, Shweta S., Stein, Caleb, Stephens, Owen W., Tytarenko, Ruslana, Bauer, Michael A., Meissner, Tobias, Deshpande, Shayu, Patel, Purvi H., Buzder, Timea, Molnar, Gabor, Peterson, Erich A., van Rhee, Frits, Zangari, Maurizio, Thanendrarajan, Sharmilan, Schinke, Carolina, Tian, Erming, Epstein, Joshua, Barlogie, Bart, Davies, Faith E., Heuck, Christoph J., Walker, Brian A, Morgan, Gareth J.
Published in Blood (29.09.2016)
Published in Blood (29.09.2016)
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Journal Article
Sustained minimal residual disease negativity in newly diagnosed multiple myeloma and the impact of daratumumab in MAIA and ALCYONE
San-Miguel, Jesus, Avet-Loiseau, Hervé, Paiva, Bruno, Kumar, Shaji, Dimopoulos, Meletios A., Facon, Thierry, Mateos, María-Victoria, Touzeau, Cyrille, Jakubowiak, Andrzej, Usmani, Saad Z., Cook, Gordon, Cavo, Michele, Quach, Hang, Ukropec, Jon, Ramaswami, Priya, Pei, Huiling, Qi, Mia, Sun, Steven, Wang, Jianping, Krevvata, Maria, DeAngelis, Nikki, Heuck, Christoph, Van Rampelbergh, Rian, Kudva, Anupa, Kobos, Rachel, Qi, Ming, Bahlis, Nizar J.
Published in Blood (27.01.2022)
Published in Blood (27.01.2022)
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Journal Article
Mechanism of action of lenalidomide in hematological malignancies
Kotla, Venumadhav, Goel, Swati, Nischal, Sangeeta, Heuck, Christoph, Vivek, Kumar, Das, Bhaskar, Verma, Amit
Published in Journal of hematology and oncology (12.08.2009)
Published in Journal of hematology and oncology (12.08.2009)
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Journal Article
Assessment of Total Lesion Glycolysis by 18F FDG PET/CT Significantly Improves Prognostic Value of GEP and ISS in Myeloma
McDonald, James E., Kessler, Marcus M., Gardner, Michael W., Buros, Amy F., Ntambi, James A., Waheed, Sarah, van Rhee, Frits, Zangari, Maurizio, Heuck, Christoph J., Petty, Nathan, Schinke, Carolina, Thanendrarajan, Sharmilan, Mitchell, Alan, Hoering, Antje, Barlogie, Bart, Morgan, Gareth J., Davies, Faith E.
Published in Clinical cancer research (15.04.2017)
Published in Clinical cancer research (15.04.2017)
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Journal Article
Daratumumab monotherapy for patients with intermediate-risk or high-risk smoldering multiple myeloma: a randomized, open-label, multicenter, phase 2 study (CENTAURUS)
Landgren, C. Ola, Chari, Ajai, Cohen, Yael C., Spencer, Andrew, Voorhees, Peter, Estell, Jane A., Sandhu, Irwindeep, Jenner, Matthew W., Williams, Catherine, Cavo, Michele, van de Donk, Niels W. C. J., Beksac, Meral, Moreau, Philippe, Goldschmidt, Hartmut, Kuppens, Steven, Bandekar, Rajesh, Clemens, Pamela L., Neff, Tobias, Heuck, Christoph, Qi, Ming, Hofmeister, Craig C.
Published in Leukemia (01.07.2020)
Published in Leukemia (01.07.2020)
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Journal Article
Extramedullary disease portends poor prognosis in multiple myeloma and is over-represented in high-risk disease even in the era of novel agents
USMANI, Saad Z, HEUCK, Christoph, VAN RHEE, Frits, CROWLEY, John, BARLOGIE, Bart, MITCHELL, Alan, SZYMONIFKA, Jackie, NAIR, Bijay, HOERING, Antje, ALSAYED, Yazan, WAHEED, Sarah, HAIDER, Sajjad, RESTREPO, Alejandro
Published in Haematologica (Roma) (01.11.2012)
Published in Haematologica (Roma) (01.11.2012)
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Journal Article
Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma
Hu, Bo, Chen, Yu, Usmani, Saad Z, Ye, Shiqiao, Qiang, Wei, Papanikolaou, Xenofon, Heuck, Christoph J, Yaccoby, Shmuel, Williams, Bart O, Van Rhee, Frits, Barlogie, Bart, Epstein, Joshua, Qiang, Ya-Wei
Published in PloS one (16.09.2013)
Published in PloS one (16.09.2013)
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Journal Article
Pharmacogenomics of bortezomib test-dosing identifies hyperexpression of proteasome genes, especially PSMD4, as novel high-risk feature in myeloma treated with Total Therapy 3
Shaughnessy, John D., Qu, Pingping, Usmani, Saad, Heuck, Christoph J., Zhang, Qing, Zhou, Yiming, Tian, Erming, Hanamura, Ichiro, van Rhee, Frits, Anaissie, Elias, Epstein, Joshua, Nair, Bijay, Stephens, Owen, Williams, Ryan, Waheed, Sarah, Alsayed, Yazan, Crowley, John, Barlogie, Bart
Published in Blood (29.09.2011)
Published in Blood (29.09.2011)
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Journal Article
Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations
Will, Britta, Zhou, Li, Vogler, Thomas O., Ben-Neriah, Susanna, Schinke, Carolina, Tamari, Roni, Yu, Yiting, Bhagat, Tushar D., Bhattacharyya, Sanchari, Barreyro, Laura, Heuck, Christoph, Mo, Yonkai, Parekh, Samir, McMahon, Christine, Pellagatti, Andrea, Boultwood, Jacqueline, Montagna, Cristina, Silverman, Lewis, Maciejewski, Jaroslaw, Greally, John M., Ye, B. Hilda, List, Alan F., Steidl, Christian, Steidl, Ulrich, Verma, Amit
Published in Blood (06.09.2012)
Published in Blood (06.09.2012)
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Journal Article
Myeloma is characterized by stage-specific alterations in DNA methylation that occur early during myelomagenesis
Heuck, Christoph J, Mehta, Jayesh, Bhagat, Tushar, Gundabolu, Krishna, Yu, Yiting, Khan, Shahper, Chrysofakis, Grigoris, Schinke, Carolina, Tariman, Joseph, Vickrey, Eric, Pulliam, Natalie, Nischal, Sangeeta, Zhou, Li, Bhattacharyya, Sanchari, Meagher, Richard, Hu, Caroline, Maqbool, Shahina, Suzuki, Masako, Parekh, Samir, Reu, Frederic, Steidl, Ulrich, Greally, John, Verma, Amit, Singhal, Seema B
Published in The Journal of immunology (1950) (15.03.2013)
Published in The Journal of immunology (1950) (15.03.2013)
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Journal Article
The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma
Pawlyn, Charlotte, Kaiser, Martin F, Heuck, Christoph, Melchor, Lorenzo, Wardell, Christopher P, Murison, Alex, Chavan, Shweta S, Johnson, David C, Begum, Dil B, Dahir, Nasrin M, Proszek, Paula Z, Cairns, David A, Boyle, Eileen M, Jones, John R, Cook, Gordon, Drayson, Mark T, Owen, Roger G, Gregory, Walter M, Jackson, Graham H, Barlogie, Bart, Davies, Faith E, Walker, Brian A, Morgan, Gareth J
Published in Clinical cancer research (01.12.2016)
Published in Clinical cancer research (01.12.2016)
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Journal Article
Jumping translocations of 1q12 in multiple myeloma: a novel mechanism for deletion of 17p in cytogenetically defined high-risk disease
Sawyer, Jeffrey R., Tian, Erming, Heuck, Christoph J., Epstein, Joshua, Johann, Donald J., Swanson, Charles M., Lukacs, Janet L., Johnson, Marian, Binz, Regina, Boast, Angela, Sammartino, Gael, Usmani, Saad, Zangari, Maurizio, Waheed, Sarah, van Rhee, Frits, Barlogie, Bart
Published in Blood (17.04.2014)
Published in Blood (17.04.2014)
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Journal Article
Second malignancies in total therapy 2 and 3 for newly diagnosed multiple myeloma: influence of thalidomide and lenalidomide during maintenance
Usmani, Saad Z., Sexton, Rachel, Hoering, Antje, Heuck, Christoph J., Nair, Bijay, Waheed, Sarah, Al Sayed, Yazan, Chauhan, Nabeel, Ahmad, Nisar, Atrash, Shebli, Petty, Nathan, van Rhee, Frits, Crowley, John, Barlogie, Bart
Published in Blood (23.08.2012)
Published in Blood (23.08.2012)
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Journal Article
Final analysis of the phase III non-inferiority COLUMBA study of subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma
Usmani, Saad Z, Nahi, Hareth, Legiec, Wojciech, Grosicki, Sebastian, Vorobyev, Vladimir, Spicka, Ivan, Hungria, Vania, Korenkova, Sibirina, Bahlis, Nizar J, Flogegard, Max, Bladé, Joan, Moreau, Philippe, Kaiser, Martin, Iida, Shinsuke, Laubach, Jacob, Magen, Hila, Cavo, Michele, Hulin, Cyrille, White, Darrell, De Stefano, Valerio, Lantz, Kristen, O'Rourke, Lisa, Heuck, Christoph, Delioukina, Maria, Qin, Xiang, Nnane, Ivo, Qi, Ming, Mateos, Maria-Victoria
Published in Haematologica (Roma) (01.10.2022)
Published in Haematologica (Roma) (01.10.2022)
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Journal Article
Multi-Subgroup Gene Screening Using Semi-Parametric Hierarchical Mixture Models and the Optimal Discovery Procedure: Application to a Randomized Clinical Trial in Multiple Myeloma
Matsui, Shigeyuki, Noma, Hisashi, Qu, Pingping, Sakai, Yoshio, Matsui, Kota, Heuck, Christoph, Crowley, John
Published in Biometrics (01.03.2018)
Published in Biometrics (01.03.2018)
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Journal Article
Evidence of an epigenetic origin for high-risk 1q21 copy number aberrations in multiple myeloma
Sawyer, Jeffrey R., Tian, Erming, Heuck, Christoph J., Johann, Donald J., Epstein, Joshua, Swanson, Charles M., Lukacs, Janet L., Binz, Regina Lichti, Johnson, Marian, Sammartino, Gael, Zangari, Maurizio, Davies, Faith E., van Rhee, Frits, Morgan, Gareth J., Barlogie, Bart
Published in Blood (11.06.2015)
Published in Blood (11.06.2015)
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Journal Article
GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review
Rodriguez-Otero, Paula, van de Donk, Niels W. C. J., Pillarisetti, Kodandaram, Cornax, Ingrid, Vishwamitra, Deeksha, Gray, Kathleen, Hilder, Brandi, Tolbert, Jaszianne, Renaud, Thomas, Masterson, Tara, Heuck, Christoph, Kane, Colleen, Verona, Raluca, Moreau, Philippe, Bahlis, Nizar, Chari, Ajai
Published in Blood cancer journal (New York) (02.02.2024)
Published in Blood cancer journal (New York) (02.02.2024)
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Journal Article
Greater treatment satisfaction in patients receiving daratumumab subcutaneous vs. intravenous for relapsed or refractory multiple myeloma: COLUMBA clinical trial results
Usmani, Saad Z., Mateos, Maria-Victoria, Hungria, Vania, Iida, Shinsuke, Bahlis, Nizar J., Nahi, Hareth, Magen, Hila, Cavo, Michele, Hulin, Cyrille, White, Darrell, De Stefano, Valerio, Fastenau, John, Slavcev, Mary, Heuck, Christoph, Qin, Xiang, Pei, Huiling, Masterson, Tara, Lantz, Kristen, Gries, Katharine S.
Published in Journal of cancer research and clinical oncology (01.02.2021)
Published in Journal of cancer research and clinical oncology (01.02.2021)
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Journal Article
In multiple myeloma, 14q32 translocations are nonrandom chromosomal fusions driving high expression levels of the respective partner genes
Tian, Erming, Sawyer, Jeffrey R., Heuck, Christoph J., Zhang, Qing, van Rhee, Frits, Barlogie, Bart, Epstein, Joshua
Published in Genes chromosomes & cancer (01.07.2014)
Published in Genes chromosomes & cancer (01.07.2014)
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