Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients
Moss, Laurence M, Algera, Marijke Hyke, Dobbins, Robert, Gray, Frank, Strafford, Stephanie, Heath, Amy, van Velzen, Monique, Heuberger, Jules A A C, Niesters, Marieke, Olofsen, Erik, Laffont, Celine M, Dahan, Albert, Groeneveld, Geert Jan
Published in PloS one (27.01.2022)
Published in PloS one (27.01.2022)
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Journal Article
EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis
Hidalgo, Daniel, Bejder, Jacob, Pop, Ramona, Gellatly, Kyle, Hwang, Yung, Maxwell Scalf, S, Eastman, Anna E, Chen, Jane-Jane, Zhu, Lihua Julie, Heuberger, Jules A A C, Guo, Shangqin, Koury, Mark J, Nordsborg, Nikolai Baastrup, Socolovsky, Merav
Published in Nature communications (17.12.2021)
Published in Nature communications (17.12.2021)
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Journal Article
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease
Jennings, Danna, Huntwork‐Rodriguez, Sarah, Vissers, Maurits F.J.M., Daryani, Vinay M., Diaz, Dolores, Goo, Marisa S., Chen, John J., Maciuca, Romeo, Fraser, Kyle, Mabrouk, Omar S., Wetering de Rooij, Jeroen, Heuberger, Jules A.A.C., Groeneveld, Geert Jan, Borin, Marie T., Cruz‐Herranz, Andrés, Graham, Danielle, Scearce‐Levie, Kimberly, De Vicente, Javier, Henry, Anastasia G., Chin, Peter, Ho, Carole, Troyer, Matthew D.
Published in Movement disorders (01.03.2023)
Published in Movement disorders (01.03.2023)
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Journal Article
Dealing with doping. A plea for better science, governance and education
Heuberger, Jules A. A. C., Henning, April, Cohen, Adam F., Kayser, Bengt
Published in British journal of clinical pharmacology (01.02.2022)
Published in British journal of clinical pharmacology (01.02.2022)
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Journal Article
Inappropriate Study Design Produces Spurious Effects of Autologous Blood Transfusion
Heuberger, Jules A A C, Cohen, Adam F
Published in Medicine and science in sports and exercise (01.07.2019)
Published in Medicine and science in sports and exercise (01.07.2019)
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Journal Article
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers
Grievink, Hendrika W, Heuberger, Jules A A C, Huang, Fen, Chaudhary, Rinkal, Birkhoff, Willem A J, Tonn, George R, Mosesova, Sofia, Erickson, Rebecca, Moerland, Matthijs, Haddick, Patrick C G, Scearce-Levie, Kimberly, Ho, Carole, Groeneveld, Geert Jan
Published in Clinical pharmacology and therapeutics (01.02.2020)
Published in Clinical pharmacology and therapeutics (01.02.2020)
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Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib studies in healthy subjects and patients
Vissers, Maurits F. J. M., Heuberger, Jules A. A. C., Groeneveld, Geert Jan, Oude Nijhuis, Jerome, De Deyn, Peter Paul, Hadi, Salah, Harris, Jeffrey, Tsai, Richard M., Cruz‐Herranz, Andres, Huang, Fen, Tong, Vincent, Erickson, Rebecca, Zhu, Yuda, Scearce‐Levie, Kimberly, Hsiao‐Nakamoto, Jennifer, Tang, Xinyan, Chang, Megan, Fox, Brian M., Estrada, Anthony A., Pomponio, Robert J., Alonso‐Alonso, Miguel, Zilberstein, Moshe, Atassi, Nazem, Troyer, Matthew D., Ho, Carole
Published in Clinical and translational science (01.08.2022)
Published in Clinical and translational science (01.08.2022)
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Journal Article
Acute Effects of Riluzole and Retigabine on Axonal Excitability in Patients With Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial
Kovalchuk, Maria O, Heuberger, Jules A A C, Sleutjes, Boudewijn T H M, Ziagkos, Dimitrios, van den Berg, Leonard H, Ferguson, Toby A, Franssen, Hessel, Groeneveld, Geert Jan
Published in Clinical pharmacology and therapeutics (01.12.2018)
Published in Clinical pharmacology and therapeutics (01.12.2018)
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Journal Article
In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms
Sy, Sherwin K B, Beaudoin, Marie-Eve, Zhuang, Luning, Löblein, Kathrin I, Lux, Clemens, Kissel, Marlene, Tremmel, Robin, Frank, Christian, Strasser, Severin, Heuberger, Jules A A C, Mulder, Midas B, Schuck, Virna J, Derendorf, Hartmut
Published in Journal of antimicrobial chemotherapy (01.07.2016)
Published in Journal of antimicrobial chemotherapy (01.07.2016)
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Journal Article
Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes
Heuberger, Jules A. A. C., Posthuma, Jelle J., Ziagkos, Dimitrios, Rotmans, Joris I., Daniels, Johannes M. A., Gal, Pim, Stuurman, Frederik E., Spronk, Henri M. H., Ten Cate, Hugo, Burggraaf, Jacobus, Moerland, Matthijs, Cohen, Adam F.
Published in European journal of applied physiology (01.08.2020)
Published in European journal of applied physiology (01.08.2020)
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Journal Article
Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study
Ruijs, Titia Q., Koopmans, Ingrid W., Kam, Marieke L., Esdonk, Michiel J., Koltzenburg, Martin, Groeneveld, Geert Jan, Heuberger, Jules A.A.C.
Published in Clinical pharmacology and therapeutics (01.11.2022)
Published in Clinical pharmacology and therapeutics (01.11.2022)
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Journal Article
A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls
Vissers, Maurits F. J. M., Troyer, Matthew D., Thijssen, Eva, Pereira, Diana R., Heuberger, | Jules A. A. C., Groeneveld, Geert Jan, Huntwork‐Rodriguez, Sarah
Published in Clinical and translational science (01.08.2023)
Published in Clinical and translational science (01.08.2023)
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Journal Article
Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double‐blind, placebo‐controlled, cross‐over study
Ruijs, Titia Q., Heuberger, Jules A. A. C., Goede, Annika A., Ziagkos, Dimitrios, Otto, Marije E., Doll, Robert J., Putten, Michel J. A. M., Groeneveld, Geert Jan
Published in British journal of clinical pharmacology (01.06.2022)
Published in British journal of clinical pharmacology (01.06.2022)
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Journal Article
Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders
Vissers, Maurits F J M, Heuberger, Jules A A C, Groeneveld, Geert Jan
Published in International journal of molecular sciences (05.02.2021)
Published in International journal of molecular sciences (05.02.2021)
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Journal Article
Good Clinical Trials by removing defensive interpretation of Good Clinical Practice guidelines
Heijer, Jonas M., Heuberger, Jules A. A. C., Hijma, Hemme, Kruithof, Annelieke C., Smeden, Jeroen, Groeneveld, Geert Jan, Burggraaf, Jacobus, Cohen, Adam
Published in British journal of clinical pharmacology (01.12.2021)
Published in British journal of clinical pharmacology (01.12.2021)
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Journal Article
Administration of oxathridine, a first‐in‐class histamine‐3 receptor partial agonist in healthy male volunteers: Central nervous system depression and pseudo‐hallucinations
Dijkstra, Francis M., Zuiker, Rob G. J. A., Heuberger, Jules A. A. C., Kanhai, Kawita M. S., De Kam, Marieke, Duvauchelle, Thierry, Lecomte, Jeanne‐Marie, Labeeuw, Olivier, Landais, Laurent, Ligneau, Xavier, Robert, Philippe, Capet, Marc, Schwartz, Jean‐Charles, Gerven, Joop M. A.
Published in British journal of clinical pharmacology (01.01.2024)
Published in British journal of clinical pharmacology (01.01.2024)
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Journal Article
Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers
Peters, Esther, Heuberger, Jules A. A. C., Tiessen, Renger, van Elsas, Andrea, Masereeuw, Rosalinde, Arend, Jacques, Stevens, Jasper, Pickkers, Peter
Published in Clinical pharmacokinetics (01.10.2016)
Published in Clinical pharmacokinetics (01.10.2016)
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Journal Article
Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics
Heuberger, Jules A. A. C., Guan, Zheng, Oyetayo, Olubukayo-Opeyemi, Klumpers, Linda, Morrison, Paul D., Beumer, Tim L., van Gerven, Joop M. A., Cohen, Adam F., Freijer, Jan
Published in Clinical pharmacokinetics (01.02.2015)
Published in Clinical pharmacokinetics (01.02.2015)
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