Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer's disease with reduced complement activation
Hettmann, Thore, Gillies, Stephen D, Kleinschmidt, Martin, Piechotta, Anke, Makioka, Koki, Lemere, Cynthia A, Schilling, Stephan, Rahfeld, Jens-Ulrich, Lues, Inge
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Published in Scientific reports (24.02.2020)
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A Low-Toxicity IL-2―Based Immunocytokine Retains Antitumor Activity Despite Its High Degree of IL-2 Receptor Selectivity
GILLIES, Stephen D, YAN LAN, HETTMANN, Thore, BRUNKHORST, Beatrice, YAPING SUN, MUELLER, Stefan O, LO, Kin-Ming
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Published in Clinical cancer research (01.06.2011)
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Monoclonal antibody blockade of the human eag1 potassium channel function exerts antitumor activity
GOMEZ-VARELA, David, ZWICK-WALLASCH, Esther, PARDO, Luis A, KNOTGEN, Hendrik, SANCHEZ, Araceli, HETTMANN, Thore, OSSIPOV, Dmitri, WESELOH, Rüdiger, CONTRERAS-JURADO, Constanza, ROTHE, Mike, STUHMER, Walter
Published in Cancer research (Chicago, Ill.) (01.08.2007)
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Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice
Crehan, Helen, Liu, Bin, Kleinschmidt, Martin, Rahfeld, Jens-Ulrich, Le, Kevin X, Caldarone, Barbara J, Frost, Jeffrey L, Hettmann, Thore, Hutter-Paier, Birgit, O'Nuallain, Brian, Park, Mi-Ae, DiCarli, Marcelo F, Lues, Inge, Schilling, Stephan, Lemere, Cynthia A
Published in Alzheimer's research & therapy (13.01.2020)
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Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer
Mendell, Jeanne, Freeman, Daniel J., Feng, Wenqin, Hettmann, Thore, Schneider, Matthias, Blum, Sabine, Ruhe, Jens, Bange, Johannes, Nakamaru, Kenji, Chen, Shuquan, Tsuchihashi, Zenta, von Pawel, Joachim, Copigneaux, Catherine, Beckman, Robert A.
Published in EBioMedicine (01.03.2015)
Published in EBioMedicine (01.03.2015)
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Abstract LB-306: U3-1287 (AMG 888), a fully human anti-HER3 mAb, inhibits HER3 activation and induces HER3 internalization and degradation
Hettmann, Thore, Schneider, Matthias, Ogbagabriel, Selam, Xie, Jiansong, Juan, Gloria, Hartmann, Susanne, Radinsky, Robert, Freeman, Daniel J.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Focused ultrasound with anti-pGlu3 Aβ enhances efficacy in Alzheimer's disease-like mice via recruitment of peripheral immune cells
Sun, Tao, Shi, Qiaoqiao, Zhang, Yongzhi, Power, Chanikarn, Hoesch, Camilla, Antonelli, Shawna, Schroeder, Maren K., Caldarone, Barbara J., Taudte, Nadine, Schenk, Mathias, Hettmann, Thore, Schilling, Stephan, McDannold, Nathan J., Lemere, Cynthia A.
Published in Journal of controlled release (10.08.2021)
Published in Journal of controlled release (10.08.2021)
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Focused ultrasound with anti-pGlu3 Aβ enhances efficacy via recruitment of peripheral immune cells
Sun, Tao, Shi, Qiaoqiao, Zhang, Yongzhi, Power, Chanikarn, Hoesch, Camilla, Antonelli, Shawna, Schroeder, Maren K., Caldarone, Barbara J., Taudte, Nadine, Schenk, Mathias, Hettmann, Thore, Schilling, Stephan, McDannold, Nathan J., Lemere, Cynthia A.
Published in Journal of controlled release (26.06.2021)
Published in Journal of controlled release (26.06.2021)
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Focus Ultrasound‐Induced Blood‐Brain Barrier opening enhances anti‐pGlu3 Aβ mAb delivery and amyloid‐beta plaque clearance
Bathini, Praveen, Sun, Tao, Shi, Qiaoqiao, Zhang, Yongzhi, Taudte, Nadine, Schenk, Mathias, Hettmann, Thore, Schilling, Stephan, McDannold, Nathan, Lemere, Cynthia A
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Structural basis of IL-23 antagonism by an Alphabody protein scaffold
Desmet, Johan, Verstraete, Kenneth, Bloch, Yehudi, Lorent, Eric, Wen, Yurong, Devreese, Bart, Vandenbroucke, Karen, Loverix, Stefan, Hettmann, Thore, Deroo, Sabrina, Somers, Klaartje, Henderikx, Paula, Lasters, Ignace, Savvides, Savvas N
Published in Nature communications (30.10.2014)
Published in Nature communications (30.10.2014)
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Phase I Study of U3-1287, a Fully Human Anti-HER3 Monoclonal Antibody, in Patients with Advanced Solid Tumors
LORUSSO, Patricia, JÄNNE, Pasi A, ANG, Agnes, HALIM, Abdel-Baset, BECKMAN, Robert A, BEAUPRE, Darrin, BERLIN, Jordan, OLIVEIRA, Moacyr, RIZVI, Naiyer, MALBURG, Lisa, KEEDY, Vicki, YEE, Lorrin, COPIGNEAUX, Catherine, HETTMANN, Thore, WU, Chi-Yuan
Published in Clinical cancer research (01.06.2013)
Published in Clinical cancer research (01.06.2013)
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PBD-C06 – A NOVEL ANTI-PGLU3-Aβ ANTIBODY FOR IMMUNOTHERAPY AGAINST ALZHEIMER’S DISEASE
Rahfeld, Jens-Ulrich, Kleinschmidt, Martin, Gillies, Stephen D., Makioka, Kouki, Lemere, Cynthia A., Schilling, Stephan, Hettmann, Thore
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
P1‐092: PBD‐C06 – A NOVEL ANTI‐PGLU3‐Aβ ANTIBODY FOR IMMUNOTHERAPY AGAINST ALZHEIMER'S DISEASE
Rahfeld, Jens-Ulrich, Kleinschmidt, Martin, Gillies, Stephen D., Makioka, Kouki, Lemere, Cynthia A., Schilling, Stephan, Hettmann, Thore
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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