Discovery of 6‑Amino-2-{[(1S)‑1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro‑8H‑purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma
Biggadike, Keith, Ahmed, Mahbub, Ball, Doug I, Coe, Diane M, Dalmas Wilk, Deidre A, Edwards, Chris D, Gibbon, Bob H, Hardy, Charlotte J, Hermitage, Stephen A, Hessey, Joanne O, Hillegas, Aimee E, Hughes, Stephen C, Lazarides, Linos, Lewell, Xiao Q, Lucas, Amanda, Mallett, David N, Price, Mark A, Priest, Fiona M, Quint, Diana J, Shah, Poonam, Sitaram, Anesh, Smith, Stephen A, Stocker, Richard, Trivedi, Naimisha A, Tsitoura, Daphne C, Weller, Victoria
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
Get full text
Journal Article
Discovery of 6-Amino-2-{[(1 S )-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8 H -purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma
Biggadike, Keith, Ahmed, Mahbub, Ball, Doug I., Coe, Diane M., Dalmas Wilk, Deidre A., Edwards, Chris D., Gibbon, Bob H., Hardy, Charlotte J., Hermitage, Stephen A., Hessey, Joanne O., Hillegas, Aimee E., Hughes, Stephen C., Lazarides, Linos, Lewell, Xiao Q., Lucas, Amanda, Mallett, David N., Price, Mark A., Priest, Fiona M., Quint, Diana J., Shah, Poonam, Sitaram, Anesh, Smith, Stephen A., Stocker, Richard, Trivedi, Naimisha A., Tsitoura, Daphne C., Weller, Victoria
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
Get full text
Journal Article