Base metal‐catalyzed hydrogen isotope exchange
Yang, Haifeng, Hesk, David
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2020)
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2020)
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Journal Article
Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds
Loh, Yong Yao, Nagao, Kazunori, Hoover, Andrew J., Hesk, David, Rivera, Nelo R., Colletti, Steven L., Davies, Ian W., MacMillan, David W. C.
Published in Science (American Association for the Advancement of Science) (01.12.2017)
Published in Science (American Association for the Advancement of Science) (01.12.2017)
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Journal Article
Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery
Pipal, Robert W., Stout, Kenneth T., Musacchio, Patricia Z., Ren, Sumei, Graham, Thomas J. A., Verhoog, Stefan, Gantert, Liza, Lohith, Talakad G., Schmitz, Alexander, Lee, Hsiaoju S., Hesk, David, Hostetler, Eric D., Davies, Ian W., MacMillan, David W. C.
Published in Nature (London) (28.01.2021)
Published in Nature (London) (28.01.2021)
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Journal Article
Molecular Interactions in Posaconazole Amorphous Solid Dispersions from Two-Dimensional Solid-State NMR Spectroscopy
Lu, Xingyu, Huang, Chengbin, Lowinger, Michael B, Yang, Fengyuan, Xu, Wei, Brown, Chad D, Hesk, David, Koynov, Athanas, Schenck, Luke, Su, Yongchao
Published in Molecular pharmaceutics (03.06.2019)
Published in Molecular pharmaceutics (03.06.2019)
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Journal Article
Discovery of 6‑(Fluoro-18 F)‑3-(1H‑pyrrolo[2,3‑c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
Walji, Abbas M, Hostetler, Eric D, Selnick, Harold, Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Holahan, Marie, O’Malley, Stacey, Purcell, Mona, Riffel, Kerry, Li, Jing, Balsells, Jaume, OBrien, Julie A, Melquist, Stacey, Soriano, Aileen, Zhang, Xiaoping, Ogawa, Aimie, Xu, Serena, Joshi, Elizabeth, Della Rocca, Joseph, Hess, Fred J, Schachter, Joel, Hesk, David, Schenk, David, Struyk, Arie, Babaoglu, Kerim, Lohith, Talakad G, Wang, Yaode, Yang, Kun, Fu, Jianmin, Evelhoch, Jeffrey L, Coleman, Paul J
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Journal Article
Pharmacological Characterization of Sch527123, a Potent Allosteric CXCR1/CXCR2 Antagonist
Gonsiorek, Waldemar, Fan, Xuedong, Hesk, David, Fossetta, James, Qiu, Hongchen, Jakway, James, Billah, Motasim, Dwyer, Michael, Chao, Jianhua, Deno, Gregory, Taveras, Art, Lundell, Daniel J, Hipkin, R William
Published in The Journal of pharmacology and experimental therapeutics (01.08.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2007)
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Journal Article
Precision and Accuracy in the Quantitative Analysis of Biological Samples by Accelerator Mass Spectrometry: Application in Microdose Absolute Bioavailability Studies
Gao, Lan, Li, Jing, Kasserra, Claudia, Song, Qi, Arjomand, Ali, Hesk, David, Chowdhury, Swapan K
Published in Analytical chemistry (Washington) (15.07.2011)
Published in Analytical chemistry (Washington) (15.07.2011)
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Journal Article
Estimation of the extent of oral absorption in animals from oral and intravenous pharmacokinetic data in drug discovery
Nomeir, Amin A., Morrison, Richard, Prelusky, Daniel, Korfmacher, Walter, Broske, Lisa, Hesk, David, McNamara, Paul, Mei, Hong
Published in Journal of pharmaceutical sciences (01.11.2009)
Published in Journal of pharmaceutical sciences (01.11.2009)
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Journal Article
Iron-catalysed tritiation of pharmaceuticals
Pony Yu, Renyuan, Hesk, David, Rivera, Nelo, Pelczer, István, Chirik, Paul J.
Published in Nature (London) (14.01.2016)
Published in Nature (London) (14.01.2016)
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Journal Article
Characterization of Peripheral Human Cannabinoid Receptor (hCB2) Expression and Pharmacology Using a Novel Radioligand, [35S]Sch225336
Gonsiorek, Waldemar, Hesk, David, Chen, Shu-Cheng, Kinsley, David, Fine, Jay S., Jackson, James V., Bober, Loretta A., Deno, Gregory, Bian, Hong, Fossetta, James, Lunn, Charles A., Kozlowski, Joseph A., Lavey, Brian, Piwinski, John, Narula, Satwant K., Lundell, Daniel J., Hipkin, R. William
Published in The Journal of biological chemistry (22.09.2006)
Published in The Journal of biological chemistry (22.09.2006)
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Journal Article
Hydrogen isotope exchange labelling: A brief update
Derdau, Volker, Hesk, David
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2020)
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2020)
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Journal Article
A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals
Koniarczyk, J. Luke, Hesk, David, Overgard, Alix, Davies, Ian W, McNally, Andrew
Published in Journal of the American Chemical Society (14.02.2018)
Published in Journal of the American Chemical Society (14.02.2018)
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Journal Article
Ni(I)–X Complexes Bearing a Bulky α‑Diimine Ligand: Synthesis, Structure, and Superior Catalytic Performance in the Hydrogen Isotope Exchange in Pharmaceuticals
Zarate, Cayetana, Yang, Haifeng, Bezdek, Máté J, Hesk, David, Chirik, Paul J
Published in Journal of the American Chemical Society (27.03.2019)
Published in Journal of the American Chemical Society (27.03.2019)
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Journal Article
Evernimicin Binds Exclusively to the 50S Ribosomal Subunit and Inhibits Translation in Cell-Free Systems Derived from both Gram-Positive and Gram-Negative Bacteria
MCNICHOLAS, P. M, NAJARIAN, D. J, MANN, P. A, HESK, D, HARE, R. S, SHAW, K. J, BLACK, T. A
Published in Antimicrobial Agents and Chemotherapy (01.05.2000)
Published in Antimicrobial Agents and Chemotherapy (01.05.2000)
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Journal Article
Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor
Decker, Ann M., Rahman, Md Toufiqur, Kormos, Chad M., Hesk, David, Darcq, Emmanuel, Kieffer, Brigitte L., Jin, Chunyang
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
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Journal Article
Electrochemical bromination of late stage intermediates and drug molecules
Tan, Zheng, Liu, Yong, Helmy, Roy, Rivera, Nelo R., Hesk, David, Tyagarajan, Sriram, Yang, Lu, Su, Jing
Published in Tetrahedron letters (02.08.2017)
Published in Tetrahedron letters (02.08.2017)
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Journal Article
Binding of a Thrombin Receptor Tethered Ligand Analogue to Human Platelet Thrombin Receptor
Ahn, H S, Foster, C, Boykow, G, Arik, L, Smith-Torhan, A, Hesk, D, Chatterjee, M
Published in Molecular pharmacology (01.02.1997)
Published in Molecular pharmacology (01.02.1997)
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Journal Article