FAF-Drugs2: free ADME/tox filtering tool to assist drug discovery and chemical biology projects
Lagorce, David, Sperandio, Olivier, Galons, Hervé, Miteva, Maria A, Villoutreix, Bruno O
Published in BMC bioinformatics (24.09.2008)
Published in BMC bioinformatics (24.09.2008)
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Journal Article
Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1
Oumata, Nassima, Bettayeb, Karima, Ferandin, Yoan, Demange, Luc, Lopez-Giral, Angela, Goddard, Marie-Lorène, Myrianthopoulos, Vassilios, Mikros, Emmanuel, Flajolet, Marc, Greengard, Paul, Meijer, Laurent, Galons, Hervé
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
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Journal Article
F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia
Du, Chunyang, Li, Shuangshuang, Li, Yuan, Galons, Hervé, Guo, Na, Teng, Yuou, Zhang, Yongmin, Li, Mingyuan, Yu, Peng
Published in Drug delivery (01.01.2020)
Published in Drug delivery (01.01.2020)
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Journal Article
A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment
Guyot, Anne-Cécile, Leuxe, Charlotte, Disdier, Clémence, Oumata, Nassima, Costa, Narciso, Roux, Gwenaëlle Le, Varela, Paloma F., Duchon, Arnaud, Charbonnier, Jean Baptiste, Herault, Yann, Pavoni, Serena, Galons, Hervé, Andriambeloson, Emile, Wagner, Stéphanie, Meijer, Laurent, Lund, Amie K., Mabondzo, Aloïse
Published in Scientific reports (24.01.2020)
Published in Scientific reports (24.01.2020)
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Journal Article
TRPC6 channel translocation into phagosomal membrane augments phagosomal function
Riazanski, Vladimir, Gabdoulkhakova, Aida G., Boynton, Lin S., Eguchi, Raphael R., Deriy, Ludmila V., Hogarth, D. Kyle, Loaëc, Nadège, Oumata, Nassima, Galons, Hervé, Brown, Mary E., Shevchenko, Pavel, Gallan, Alexander J., Yoo, Sang Gune, Naren, Anjaparavanda P., Villereal, Mitchel L., Beacham, Daniel W., Bindokas, Vytautas P., Birnbaumer, Lutz, Meijer, Laurent, Nelson, Deborah J.
Published in Proceedings of the National Academy of Sciences - PNAS (24.11.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (24.11.2015)
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Journal Article
Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor
Bendjeddou, Lyamin Z., Loaëc, Nadège, Villiers, Benoît, Prina, Eric, Späth, Gerald F., Galons, Hervé, Meijer, Laurent, Oumata, Nassima
Published in European journal of medicinal chemistry (05.01.2017)
Published in European journal of medicinal chemistry (05.01.2017)
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Journal Article
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity
Durieu, Emilie, Prina, Eric, Leclercq, Olivier, Oumata, Nassima, Gaboriaud-Kolar, Nicolas, Vougogiannopoulou, Konstantina, Aulner, Nathalie, Defontaine, Audrey, No, Joo Hwan, Ruchaud, Sandrine, Skaltsounis, Alexios-Leandros, Galons, Hervé, Späth, Gerald F, Meijer, Laurent, Rachidi, Najma
Published in Antimicrobial agents and chemotherapy (01.05.2016)
Published in Antimicrobial agents and chemotherapy (01.05.2016)
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Journal Article
CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD
Bukanov, Nikolay O., Moreno, Sarah E., Natoli, Thomas A., Rogers, Kelly A., Smith, Laurie A., Ledbetter, Steven R., Oumata, Nassima, Galons, Hervé, Meijer, Laurent, Ibraghimov-Beskrovnaya, Oxana
Published in Cell cycle (Georgetown, Tex.) (01.11.2012)
Published in Cell cycle (Georgetown, Tex.) (01.11.2012)
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Journal Article
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions
Tribouillard-Tanvier, Déborah, Béringue, Vincent, Desban, Nathalie, Gug, Fabienne, Bach, Stéphane, Voisset, Cécile, Galons, Hervé, Laude, Hubert, Vilette, Didier, Blondel, Marc
Published in PloS one (23.04.2008)
Published in PloS one (23.04.2008)
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Journal Article
The Antiprion Compound 6-Aminophenanthridine Inhibits the Protein Folding Activity of the Ribosome by Direct Competition
Pang, Yanhong, Kurella, Sriram, Voisset, Cécile, Samanta, Dibyendu, Banerjee, Debapriya, Schabe, Ariane, Das Gupta, Chanchal, Galons, Hervé, Blondel, Marc, Sanyal, Suparna
Published in The Journal of biological chemistry (28.06.2013)
Published in The Journal of biological chemistry (28.06.2013)
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Journal Article
The toll-like receptor agonist imiquimod is active against prions
Oumata, Nassima, Nguyen, Phu Hai, Beringue, Vincent, Soubigou, Flavie, Pang, Yanhong, Desban, Nathalie, Massacrier, Catherine, Morel, Yannis, Paturel, Carine, Contesse, Marie-Astrid, Bouaziz, Serge, Sanyal, Suparna, Galons, Hervé, Blondel, Marc, Voisset, Cécile
Published in PloS one (16.08.2013)
Published in PloS one (16.08.2013)
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Journal Article
A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced Stiffenings/Loosenings of Rotational Barriers?
El Hage, Krystel, Piquemal, Jean-Philip, Oumata, Nassima, Meijer, Laurent, Galons, Hervé, Gresh, Nohad
Published in ACS omega (31.07.2017)
Published in ACS omega (31.07.2017)
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Journal Article
Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis
Meijer, Laurent, Nelson, Deborah J., Riazanski, Vladimir, Gabdoulkhakova, Aida G., Hery-Arnaud, Geneviève, Le Berre, Rozenn, Loaëc, Nadège, Oumata, Nassima, Galons, Hervé, Nowak, Emmanuel, Gueganton, Laetitia, Dorothée, Guillaume, Prochazkova, Michaela, Hall, Bradford, Kulkarni, Ashok B., Gray, Robert D., Rossi, Adriano G., Witko-Sarsat, Véronique, Norez, Caroline, Becq, Frédéric, Ravel, Denis, Mottier, Dominique, Rault, Gilles
Published in Journal of innate immunity (01.01.2016)
Published in Journal of innate immunity (01.01.2016)
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Journal Article
Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents
Houzé, Sandrine, Hoang, Nha-Thu, Lozach, Olivier, Le Bras, Jacques, Meijer, Laurent, Galons, Hervé, Demange, Luc
Published in Molecules (Basel, Switzerland) (23.09.2014)
Published in Molecules (Basel, Switzerland) (23.09.2014)
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Journal Article
Use of ATP analogs to inhibit HIV-1 transcription
Narayanan, Aarthi, Sampey, Gavin, Van Duyne, Rachel, Guendel, Irene, Kehn-Hall, Kylene, Roman, Jessica, Currer, Robert, Galons, Hervé, Oumata, Nassima, Joseph, Benoît, Meijer, Laurent, Caputi, Massimo, Nekhai, Sergei, Kashanchi, Fatah
Published in Virology (New York, N.Y.) (10.10.2012)
Published in Virology (New York, N.Y.) (10.10.2012)
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Journal Article
Author Correction: A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment
Guyot, Anne-Cécile, Leuxe, Charlotte, Disdier, Clémence, Oumata, Nassima, Costa, Narciso, Le Roux, Gwenaëlle, Varela, Paloma F., Duchon, Arnaud, Charbonnier, Jean Baptiste, Herault, Yann, Pavoni, Serena, Galons, Hervé, Andriambeloson, Emile, Wagner, Stéphanie, Meijer, Laurent, Lund, Amie K., Mabondzo, Aloïse
Published in Scientific reports (03.07.2020)
Published in Scientific reports (03.07.2020)
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Journal Article
Inhibition of NF-κB―Mediated Signaling by the Cyclin-Dependent Kinase Inhibitor CR8 Overcomes Prosurvival Stimuli to Induce Apoptosis in Chronic Lymphocytic Leukemia Cells
COSIMO, Emilio, MCCAIG, Alison M, MEIJER, Laurent, MICHIE, Alison M, CARTER-BRZEZINSKI, Luke J. M, WHEADON, Helen, LEACH, Michael T, LE STER, Karine, BERTHOU, Christian, DURIEU, Emilie, OUMATA, Nassima, GALONS, Hervé
Published in Clinical cancer research (01.05.2013)
Published in Clinical cancer research (01.05.2013)
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Journal Article
Isolation of drugs active against mammalian prions using a yeast-based screening assay
Meijer, Laurent, Blondel, Marc, Talarek, Nicolas, Cullin, Christophe, Mettey, Yvette, Bach, Stéphane, Vierfond, Jean-Michel, Dormont, Dominique, Andrieu, Thibault, Galons, Hervé
Published in Nature biotechnology (01.09.2003)
Published in Nature biotechnology (01.09.2003)
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Journal Article
Targeting low molecular weight cyclin E (LMW-E) in breast cancer
Nanos-Webb, Angela, Jabbour, Natalie A., Multani, Asha S., Wingate, Hannah, Oumata, Nassima, Galons, Hervé, Joseph, Benoît, Meijer, Laurent, Hunt, Kelly K., Keyomarsi, Khandan
Published in Breast cancer research and treatment (01.04.2012)
Published in Breast cancer research and treatment (01.04.2012)
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Journal Article