Pharmacological interventions to improve cognition and adaptive functioning in Down syndrome: Strides to date
Hart, Sarah J., Visootsak, Jeannie, Tamburri, Paul, Phuong, Patrick, Baumer, Nicole, Hernandez, Maria‐Clemencia, Skotko, Brian G., Ochoa‐Lubinoff, Cesar, Liogier D'Ardhuy, Xavier, Kishnani, Priya S., Spiridigliozzi, Gail A.
Published in American journal of medical genetics. Part A (01.11.2017)
Published in American journal of medical genetics. Part A (01.11.2017)
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Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man
Hipp, Joerg F., Knoflach, Frederic, Comley, Robert, Ballard, Theresa M., Honer, Michael, Trube, Gerhard, Gasser, Rodolfo, Prinssen, Eric, Wallace, Tanya L., Rothfuss, Andreas, Knust, Henner, Lennon-Chrimes, Sian, Derks, Michael, Bentley, Darren, Squassante, Lisa, Nave, Stephane, Nöldeke, Jana, Wandel, Christoph, Thomas, Andrew W., Hernandez, Maria-Clemencia
Published in Scientific reports (08.04.2021)
Published in Scientific reports (08.04.2021)
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Simultaneous Optical Recording in Multiple Cells by Digital Holographic Microscopy of Chloride Current Associated to Activation of the Ligand-Gated Chloride Channel GABAA Receptor
Jourdain, Pascal, Boss, Daniel, Rappaz, Benjamin, Moratal, Corinne, Hernandez, Maria-Clemencia, Depeursinge, Christian, Magistretti, Pierre Julius, Marquet, Pierre
Published in PloS one (07.12.2012)
Published in PloS one (07.12.2012)
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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction
Knust, Henner, Achermann, Guido, Ballard, Theresa, Buettelmann, Bernd, Gasser, Rodolfo, Fischer, Holger, Hernandez, Maria-Clemencia, Knoflach, Frédéric, Koblet, Andreas, Stadler, Heinz, Thomas, Andrew W., Trube, Gerhard, Waldmeier, Pius
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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GABAA receptor-mediated neurotransmission: Not so simple after all
Knoflach, Frédéric, Hernandez, Maria-Clemencia, Bertrand, Daniel
Published in Biochemical pharmacology (01.09.2016)
Published in Biochemical pharmacology (01.09.2016)
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Journal Article
RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors
Ballard, Theresa M., Knoflach, Frédéric, Prinssen, Eric, Borroni, Edilio, Vivian, Jeffrey A., Basile, Jennifer, Gasser, Rodolfo, Moreau, Jean-Luc, Wettstein, Joseph G., Buettelmann, Bernd, Knust, Henner, Thomas, Andrew W., Trube, Gerhard, Hernandez, Maria-Clemencia
Published in Psychopharmacology (01.01.2009)
Published in Psychopharmacology (01.01.2009)
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Electrophysiological Phenotype in Angelman Syndrome Differs Between Genotypes
Frohlich, Joel, Miller, Meghan T., Bird, Lynne M., Garces, Pilar, Purtell, Hannah, Hoener, Marius C., Philpot, Benjamin D., Sidorov, Michael S., Tan, Wen-Hann, Hernandez, Maria-Clemencia, Rotenberg, Alexander, Jeste, Shafali S., Krishnan, Michelle, Khwaja, Omar, Hipp, Joerg F.
Published in Biological psychiatry (1969) (01.05.2019)
Published in Biological psychiatry (1969) (01.05.2019)
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Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series
ACHERMANN, Guido, BALLARD, Theresa M, KOBLET, Andreas, KNUST, Henner, KURT, Anke, MARTIN, James R, MASCIADRI, Raffaello, PORTER, Richard H. P, STADLER, Heinz, THOMAS, Andrew W, TRUBE, Gerhard, WICHMANN, Jürgen, BLASCO, Francesca, BROUTIN, Pierre-Emmanuel, BÜTTELMANN, Bernd, FISCHER, Holger, GRAF, Martin, HERNANDEZ, Maria-Clemencia, HILTY, Peter, KNOFLACH, Frédéric
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors
Kasaragod, Vikram Babu, Malinauskas, Tomas, Wahid, Ayla A., Lengyel, Judith, Knoflach, Frederic, Hardwick, Steven W., Jones, Charlotte F., Chen, Wan-Na, Lucas, Xavier, El Omari, Kamel, Chirgadze, Dimitri Y., Aricescu, A. Radu, Cecere, Giuseppe, Hernandez, Maria-Clemencia, Miller, Paul S.
Published in Nature structural & molecular biology (01.12.2023)
Published in Nature structural & molecular biology (01.12.2023)
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Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome
Martínez-Cué, Carmen, Martínez, Paula, Rueda, Noemí, Vidal, Rebeca, García, Susana, Vidal, Verónica, Corrales, Andrea, Montero, Juan A, Pazos, Ángel, Flórez, Jesús, Gasser, Rodolfo, Thomas, Andrew W, Honer, Michael, Knoflach, Frédéric, Trejo, Jose Luis, Wettstein, Joseph G, Hernández, Maria-Clemencia
Published in The Journal of neuroscience (27.02.2013)
Published in The Journal of neuroscience (27.02.2013)
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Decreasing the Expression of GABAA α5 Subunit-Containing Receptors Partially Improves Cognitive, Electrophysiological, and Morphological Hippocampal Defects in the Ts65Dn Model of Down Syndrome
Vidal, Verónica, García-Cerro, Susana, Martínez, Paula, Corrales, Andrea, Lantigua, Sara, Vidal, Rebeca, Rueda, Noemí, Ozmen, Laurence, Hernández, Maria-Clemencia, Martínez-Cué, Carmen
Published in Molecular neurobiology (01.06.2018)
Published in Molecular neurobiology (01.06.2018)
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A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABAA-α5 NAM (basmisanil) on intellectual disability associated with Down syndrome
Goeldner, Celia, Kishnani, Priya S., Skotko, Brian G., Casero, Julian Lirio, Hipp, Joerg F., Derks, Michael, Hernandez, Maria-Clemencia, Khwaja, Omar, Lennon-Chrimes, Sian, Noeldeke, Jana, Pellicer, Sabine, Squassante, Lisa, Visootsak, Jeannie, Wandel, Christoph, Fontoura, Paulo, d’Ardhuy, Xavier Liogier, De La Torre Fornell, Rafael, Glue, Paul, Hoover-Fong, Julie, Uhlmann, Sonja, Malagón Valdez, Jorge, Marshall, Andrew, Martinón-Torres, Federico, Redondo-Collazo, Lorenzo, Rodriguez-Tenreiro, Carmen, Marquez Chin, Valeria, Michel Reynoso, Adriana G., Mitchell, Ed A., Slykerman, Rebecca F., Wouldes, Trecia, Loveday, Sarah, Moldenhauer, Fernando, Novell, Ramon, Ochoa, Cesar, Rafii, Michael S., Rebillat, Anne-Sophie, Sanlaville, Damien, Sarda, Pierre, Shankar, Rohit, Pulsifer, Margaret, Evans, Casey L., Silva, Alexandra M., McDonough, Mary Ellen, Stanley, Maria, McCary, Lindsay M., Vicari, Stefano, Wilcox, William, Zampino, Giuseppe, Zuddas, Alessandro
Published in Journal of neurodevelopmental disorders (05.02.2022)
Published in Journal of neurodevelopmental disorders (05.02.2022)
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Simultaneous optical recording in multiple cells by digital holographic microscopy of chloride current associated to activation of the ligand-gated chloride channel GABA(A) receptor
Jourdain, Pascal, Boss, Daniel, Rappaz, Benjamin, Moratal, Corinne, Hernandez, Maria-Clemencia, Depeursinge, Christian, Magistretti, Pierre Julius, Marquet, Pierre
Published in PloS one (2012)
Published in PloS one (2012)
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GABA A GAMMA1 PAM으로서의 피리도 디아제핀 유도체
GALLEY GUIDO, OLIVARES MORALES ANDRES MIGUEL, RUNTZ SCHMITT VALERIE, HERNANDEZ MARIA CLEMENCIA, CECERE GIUSEPPE, GOBBI LUCA, KOBLET ANDREAS
Year of Publication 14.05.2024
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Year of Publication 14.05.2024
Patent
Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA α5 inverse agonists with potential for the treatment of cognitive dysfunction
BUETTELMANN, Bernd, BALLARD, Theresa M, GASSER, Rodolfo, FISCHER, Holger, HERNANDEZ, Maria-Clemencia, KNOFLACH, Frédéric, KNUST, Henner, STADLER, Heinz, THOMAS, Andrew W, TRUBE, Gerhard
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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