Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons
Burnett, James C., Ruthel, Gordon, Stegmann, Christian M., Panchal, Rekha G., Nguyen, Tam L., Hermone, Ann R., Stafford, Robert G., Lane, Douglas J., Kenny, Tara A., McGrath, Connor F., Wipf, Peter, Stahl, Andrea M., Schmidt, James J., Gussio, Rick, Brunger, Axel T., Bavari, Sina
Published in The Journal of biological chemistry (16.02.2007)
Published in The Journal of biological chemistry (16.02.2007)
Get full text
Journal Article
Three‐Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three‐Zone Pharmacophore
Hermone, Ann R., Burnett, James C., Nuss, Jonathan E., Tressler, Lyal E., Nguyen, Tam L., Šolaja, Bogdan A., Vennerstrom, Jonathan L., Schmidt, James J., Wipf, Peter, Bavari, Sina, Gussio, Rick
Published in ChemMedChem (15.12.2008)
Published in ChemMedChem (15.12.2008)
Get full text
Journal Article
A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach
Nguyen, Tam Luong, McGrath, Connor, Hermone, Ann R, Burnett, James C, Zaharevitz, Daniel W, Day, Billy W, Wipf, Peter, Hamel, Ernest, Gussio, Rick
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
Get full text
Journal Article
A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site
Burnett, James C., Lim, Chaemin, Peyser, Brian D., Samankumara, Lalith P., Kovaliov, Marina, Colombo, Raffaele, Bulfer, Stacie L., LaPorte, Matthew G., Hermone, Ann R., McGrath, Connor F., Arkin, Michelle R., Gussio, Rick, Huryn, Donna M., Wipf, Peter
Published in Organic & biomolecular chemistry (16.05.2017)
Published in Organic & biomolecular chemistry (16.05.2017)
Get full text
Journal Article
Identification of small molecule inhibitors of anthrax lethal factor
Panchal, Rekha G, Bavari, Sina, Hermone, Ann R, Nguyen, Tam Luong, Wong, Thiang Yian, Schwarzenbacher, Robert, Schmidt, James, Lane, Douglas, McGrath, Connor, Turk, Benjamin E, Burnett, James, Aman, M Javad, Little, Stephen, Sausville, Edward A, Zaharevitz, Daniel W, Cantley, Lewis C, Liddington, Robert C, Gussio, Rick
Published in Nature structural & molecular biology (01.01.2004)
Published in Nature structural & molecular biology (01.01.2004)
Get full text
Journal Article
A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease
Burnett, James C, Opsenica, Dejan, Sriraghavan, Kamaraj, Panchal, Rekha G, Ruthel, Gordon, Hermone, Ann R, Nguyen, Tam L, Kenny, Tara A, Lane, Douglas J, McGrath, Connor F, Schmidt, James J, Vennerstrom, Jonathan L, Gussio, Rick, Šolaja, Bogdan A, Bavari, Sina
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
Get full text
Journal Article
Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity
Burnett, James C, Schmidt, James J, Stafford, Robert G, Panchal, Rekha G, Nguyen, Tam L, Hermone, Ann R, Vennerstrom, Jonathan L, McGrath, Connor F, Lane, Douglas J, Sausville, Edward A, Zaharevitz, Daniel W, Gussio, Rick, Bavari, Sina
Published in Biochemical and biophysical research communications (10.10.2003)
Published in Biochemical and biophysical research communications (10.10.2003)
Get full text
Journal Article
Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding
Burnett, James C., Schmidt, James J., McGrath, Connor F., Nguyen, Tam L., Hermone, Ann R., Panchal, Rekha G., Vennerstrom, Jonathan L., Kodukula, Krishna, Zaharevitz, Daniel W., Gussio, Rick, Bavari, Sina
Published in Bioorganic & medicinal chemistry (17.01.2005)
Published in Bioorganic & medicinal chemistry (17.01.2005)
Get full text
Journal Article
An all-atom model of the pore-like structure of hexameric VP40 from Ebola: Structural insights into the monomer–hexamer transition
Nguyen, Tam Luong, Schoehn, Guy, Weissenhorn, Winfried, Hermone, Ann R., Burnett, James C., Panchal, Rekha G., McGrath, Connor, Zaharevitz, Dan W., Aman, M. Javad, Gussio, Rick, Bavari, Sina
Published in Journal of structural biology (01.07.2005)
Published in Journal of structural biology (01.07.2005)
Get full text
Journal Article
A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach
Nguyen, Tam Luong, McGrath, Connor, Hermone, Ann R, Burnett, James C, Zaharevitz, Daniel W, Day, Billy W, Wipf, Peter, Hamel, Ernest, Gussio, Rick
Published in Journal of medicinal chemistry (01.12.2005)
Published in Journal of medicinal chemistry (01.12.2005)
Get full text
Journal Article
A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding siteElectronic supplementary information (ESI) available: Copies of 1H and 13C NMR spectra, reprints and permissions information, synthetic summary schemes, computational methods with associated Figures and Tables, and movie S1. See DOI: 10.1039/c7ob00526a
Burnett, James C, Lim, Chaemin, Peyser, Brian D, Samankumara, Lalith P, Kovaliov, Marina, Colombo, Raffaele, Bulfer, Stacie L, LaPorte, Matthew G, Hermone, Ann R, McGrath, Connor F, Arkin, Michelle R, Gussio, Rick, Huryn, Donna M, Wipf, Peter
Year of Publication 16.05.2017
Year of Publication 16.05.2017
Get full text
Journal Article
A theoretical study of anthrax lethal factor inhibition by a set of novel carbamimidolyl-aryl-vinyl-carboxamidines: A possible mechanism involving zinc-ligation by amidine
Nguyen, Tam Luong, Panchal, Rekha G., Topol, Igor A., Lane, Douglas, Kenny, Tara, Burnett, James C., Hermone, Ann R., McGrath, Connor, Burt, Stanley K., Gussio, Rick, Bavari, Sina
Published in Journal of molecular structure. Theochem (01.11.2007)
Published in Journal of molecular structure. Theochem (01.11.2007)
Get full text
Journal Article