Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Lui, Hansen, Zhang, Jiasheng, Makinson, Stefanie R., Cahill, Michelle K., Kelley, Kevin W., Huang, Hsin-Yi, Shang, Yulei, Oldham, Michael C., Martens, Lauren Herl, Gao, Fuying, Coppola, Giovanni, Sloan, Steven A., Hsieh, Christine L., Kim, Charles C., Bigio, Eileen H., Weintraub, Sandra, Mesulam, Marek-Marsel, Rademakers, Rosa, Mackenzie, Ian R., Seeley, William W., Karydas, Anna, Miller, Bruce L., Borroni, Barbara, Ghidoni, Roberta, Farese, Robert V., Paz, Jeanne T., Barres, Ben A., Huang, Eric J.
Published in Cell (05.05.2016)
Published in Cell (05.05.2016)
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Journal Article
Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice
Filiano, Anthony J, Martens, Lauren Herl, Young, Allen H, Warmus, Brian A, Zhou, Ping, Diaz-Ramirez, Grisell, Jiao, Jian, Zhang, Zhijun, Huang, Eric J, Gao, Fen-Biao, Farese, Jr, Robert V, Roberson, Erik D
Published in The Journal of neuroscience (20.03.2013)
Published in The Journal of neuroscience (20.03.2013)
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Journal Article
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
Martens, Lauren Herl, Zhang, Jiasheng, Barmada, Sami J, Zhou, Ping, Kamiya, Sherry, Sun, Binggui, Min, Sang-Won, Gan, Li, Finkbeiner, Steven, Huang, Eric J, Jr, Robert V Farese
Published in The Journal of clinical investigation (04.01.2022)
Published in The Journal of clinical investigation (04.01.2022)
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Journal Article
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD
Ward, Michael E, Taubes, Alice, Chen, Robert, Miller, Bruce L, Sephton, Chantelle F, Gelfand, Jeffrey M, Minami, Sakura, Boscardin, John, Martens, Lauren Herl, Seeley, William W, Yu, Gang, Herz, Joachim, Filiano, Anthony J, Arrant, Andrew E, Roberson, Erik D, Kraft, Timothy W, Farese, Jr, Robert V, Green, Ari, Gan, Li
Published in The Journal of experimental medicine (22.09.2014)
Published in The Journal of experimental medicine (22.09.2014)
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Journal Article
Functional Genomic Analyses Identify Pathways Dysregulated by Progranulin Deficiency, Implicating Wnt Signaling
Rosen, Ezra Y., Wexler, Eric M., Versano, Revital, Coppola, Giovanni, Gao, Fuying, Winden, Kellen D., Oldham, Michael C., Martens, Lauren Herl, Zhou, Ping, Farese, Robert V., Geschwind, Daniel H.
Published in Neuron (Cambridge, Mass.) (22.09.2011)
Published in Neuron (Cambridge, Mass.) (22.09.2011)
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Journal Article
neurodegenerative disease mutation that accelerates the clearance of apoptotic cells
Kao, Aimee W, Eisenhut, Robin J, Martens, Lauren Herl, Nakamura, Ayumi, Huang, Anne, Bagley, Josh A, Zhou, Ping, de Luis, Alberto, Neukomm, Lukas J, Cabello, Juan, Farese, Robert V. Jr, Kenyon, Cynthia
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2011)
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Journal Article
Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation
Lleo, Alberto, Berezovska, Oksana, Herl, Lauren, Raju, Susan, Deng, Amy, Bacskai, Brian J, Frosch, Matthew P, Irizarry, Michael, Hyman, Bradley T
Published in Nature medicine (01.10.2004)
Published in Nature medicine (01.10.2004)
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Journal Article
Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice
Nagy, Dávid, Martens, Lauren Herl, Leventhal, Liza, Chen, Angela, Kelley, Craig, Stoiljkovic, Milan, Hajós, Mihály
Published in Alzheimer's research & therapy (22.10.2019)
Published in Alzheimer's research & therapy (22.10.2019)
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Journal Article
Familial Alzheimer's Disease Presenilin 1 Mutations Cause Alterations in the Conformation of Presenilin and Interactions with Amyloid Precursor Protein
Berezovska, Oksana, Lleo, Alberto, Herl, Lauren D, Frosch, Matthew P, Stern, Edward A, Bacskai, Brian J, Hyman, Bradley T
Published in The Journal of neuroscience (16.03.2005)
Published in The Journal of neuroscience (16.03.2005)
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Journal Article
Interaction between Presenilin 1 and Ubiquilin 1 as Detected by Fluorescence Lifetime Imaging Microscopy and a High-throughput Fluorescent Plate Reader
Thomas, Anne V., Herl, Lauren, Spoelgen, Robert, Hiltunen, Mikko, Jones, Phill B., Tanzi, Rudolph E., Hyman, Bradley T., Berezovska, Oksana
Published in The Journal of biological chemistry (08.09.2006)
Published in The Journal of biological chemistry (08.09.2006)
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Journal Article
Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy
Herl, Lauren, Lleo, Alberto, Thomas, Anne V., Nyborg, Andrew C., Jansen, Karen, Golde, Todd E., Hyman, Bradley T., Berezovska, Oksana
Published in Biochemical and biophysical research communications (10.02.2006)
Published in Biochemical and biophysical research communications (10.02.2006)
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Journal Article
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells
Nyborg, Andrew C, Herl, Lauren, Berezovska, Oksana, Thomas, Anne V, Ladd, Thomas B, Jansen, Karen, Hyman, Bradley T, Golde, Todd E
Published in Molecular neurodegeneration (14.11.2006)
Published in Molecular neurodegeneration (14.11.2006)
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Journal Article
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
Martens, Lauren Herl, Zhang, Jiasheng, Barmada, Sami J, Zhou, Ping, Kamiya, Sherry, Sun, Binggui, Min, Sang-Won, Gan, Li, Finkbeiner, Steven, Huang, Eric J, Farese, Jr, Robert V
Published in The Journal of clinical investigation (01.11.2012)
Published in The Journal of clinical investigation (01.11.2012)
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Journal Article
Progranulin: at the interface of neurodegenerative and metabolic diseases
Nguyen, Andrew D, Nguyen, Thi A, Martens, Lauren Herl, Mitic, Laura L, Farese, Robert V
Published in Trends in endocrinology and metabolism (01.12.2013)
Published in Trends in endocrinology and metabolism (01.12.2013)
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Journal Article
The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate
von Arnim, Christine A.F., Kinoshita, Ayae, Peltan, Ithan D., Tangredi, Michelle M., Herl, Lauren, Lee, Bonny M., Spoelgen, Robert, Hshieh, Tammy T., Ranganathan, Sripriya, Battey, Frances D., Liu, Chun-Xiang, Bacskai, Brian J., Sever, Sanja, Irizarry, Michael C., Strickland, Dudley K., Hyman, Bradley T.
Published in The Journal of biological chemistry (06.05.2005)
Published in The Journal of biological chemistry (06.05.2005)
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Journal Article
An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations
Sha, Sharon J., Miller, Zachary A., Min, Sang-won, Zhou, Yungui, Brown, Jesse, Mitic, Laura L., Karydas, Anna, Koestler, Mary, Tsai, Richard, Corbetta-Rastelli, Chiara, Lin, Sophie, Hare, Emma, Fields, Scott, Fleischmann, Kirsten E., Powers, Ryan, Fitch, Ryan, Martens, Lauren Herl, Shamloo, Mehrdad, Fagan, Anne M., Farese, Robert V., Pearlman, Rodney, Seeley, William, Miller, Bruce L., Gan, Li, Boxer, Adam L.
Published in Alzheimer's & dementia : translational research & clinical interventions (01.11.2017)
Published in Alzheimer's & dementia : translational research & clinical interventions (01.11.2017)
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Journal Article
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
Martens, Lauren Herl, Zhang, Jiasheng, Barmada, Sami J, Zhou, Ping, Kamiya, Sherry, Sun, Binggui, Min, Sang-Won, Gan, Li, Finkbeiner, Steven, Huang, Eric J, Farese, Jr., Robert V
Published in The Journal of clinical investigation (01.11.2012)
Published in The Journal of clinical investigation (01.11.2012)
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Journal Article
Mutations in amyloid precursor protein affect its interactions with presenilin/γ-secretase
Herl, Lauren, Thomas, Anne V., Lill, Christina M., Banks, Mary, Deng, Amy, Jones, Phill B., Spoelgen, Robert, Hyman, Bradley T., Berezovska, Oksana
Published in Molecular and cellular neuroscience (01.06.2009)
Published in Molecular and cellular neuroscience (01.06.2009)
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Journal Article
Neuronal effects of progranulin deficiency contribute to frontotemporal dementia independent of neuroinflammation
Filiano, Anthony, Martens, Lauren Herl, Young, Allen, Warmus, Brian, Zhou, Ping, Diaz-Ramirez, Grisell, Jiao, Jian, Zhang, Zhijun, Huang, Eric, Gao, Fen-Biao, Farese, Robert, Roberson, Erik
Published in Alzheimer's & dementia (01.07.2012)
Published in Alzheimer's & dementia (01.07.2012)
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