Safety and immunogenicity of the rVSV∆G-ZEBOV-GP Ebola virus vaccine candidate in healthy adults: a phase 1b randomised, multicentre, double-blind, placebo-controlled, dose-response study
Heppner, D Gray, Dr, Kemp, Tracy L, MPH, Martin, Brian K, PhD, Ramsey, William J, MD, Nichols, Richard, MA, Dasen, Emily J, BA, Link, Charles J, MD, Das, Rituparna, MD, Xu, Zhi Jin, PhD, Sheldon, Eric A, MD, Nowak, Teresa A, BSE, Monath, Thomas P, MD
Published in The Lancet infectious diseases (01.08.2017)
Published in The Lancet infectious diseases (01.08.2017)
Get full text
Journal Article
A Field Trial to Assess a Blood-Stage Malaria Vaccine
Thera, Mahamadou A, Doumbo, Ogobara K, Coulibaly, Drissa, Laurens, Matthew B, Ouattara, Amed, Kone, Abdoulaye K, Guindo, Ando B, Traore, Karim, Traore, Idrissa, Kouriba, Bourema, Diallo, Dapa A, Diarra, Issa, Daou, Modibo, Dolo, Amagana, Tolo, Youssouf, Sissoko, Mady, Sissoko, Mahamadou S, Niangaly, Amadou, Takala-Harrison, Shannon, Lyke, Kirsten E, Wu, Yukun, Blackwelder, William C, Godeaux, Olivier, Vekemans, Johan, Dubois, Marie-Claude, Ballou, W. Ripley, Cohen, Joe, Thompson, Darby, Dube, Tina, Soisson, Lorraine, Diggs, Carter L, House, Brent, Lanar, David E, Dutta, Sheetij, Heppner, D. Gray, Plowe, Christopher V
Published in The New England journal of medicine (15.09.2011)
Published in The New England journal of medicine (15.09.2011)
Get full text
Journal Article
Randomized, Double-Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria-Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection
Kester, Kent E., Cummings, James F., Ofori-Anyinam, Opokua, Ockenhouse, Christian F., Krzych, Urszula, Moris, Philippe, Schwenk, Robert, Nielsen, Robin A., Debebe, Zufan, Pinelis, Evgeny, Juompan, Laure, Williams, Jack, Dowler, Megan, Stewart, V. Ann, Wirtz, Robert A., Dubois, Marie-Claude, Lievens, Marc, Cohen, Joe, Ballou, W. Ripley, Heppner, D. Gray
Published in The Journal of infectious diseases (01.08.2009)
Published in The Journal of infectious diseases (01.08.2009)
Get full text
Journal Article
Assessing the safety and immunogenicity of recombinant vesicular stomatitis virus Ebola vaccine in healthy adults: a randomized clinical trial
ElSherif, May S, Brown, Catherine, MacKinnon-Cameron, Donna, Li, Li, Racine, Trina, Alimonti, Judie, Rudge, Thomas L, Sabourin, Carol, Silvera, Peter, Hooper, Jay W, Kwilas, Steven A, Kilgore, Nicole, Badorrek, Christopher, Ramsey, W Jay, Heppner, D Gray, Kemp, Tracy, Monath, Thomas P, Nowak, Teresa, McNeil, Shelly A, Langley, Joanne M, Halperin, Scott A
Published in Canadian Medical Association journal (CMAJ) (19.06.2017)
Published in Canadian Medical Association journal (CMAJ) (19.06.2017)
Get full text
Journal Article
First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers
Spring, Michele, Murphy, Jittawadee, Nielsen, Robin, Dowler, Megan, Bennett, Jason W, Zarling, Stasya, Williams, Jack, de la Vega, Patricia, Ware, Lisa, Komisar, Jack, Polhemus, Mark, Richie, Thomas L, Epstein, Judy, Tamminga, Cindy, Chuang, Ilin, Richie, Nancy, O’Neil, Michael, Heppner, D. Gray, Healer, Julie, O’Neill, Matthew, Smithers, Hannah, Finney, Olivia C, Mikolajczak, Sebastian A, Wang, Ruobing, Cowman, Alan, Ockenhouse, Christian, Krzych, Urszula, Kappe, Stefan H.I
Published in Vaccine (09.10.2013)
Published in Vaccine (09.10.2013)
Get full text
Journal Article
Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area
Polhemus, Mark E, Remich, Shon A, Ogutu, Bernhards R, Waitumbi, John N, Otieno, Lucas, Apollo, Stella, Cummings, James F, Kester, Kent E, Ockenhouse, Christian F, Stewart, Ann, Ofori-Anyinam, Opokua, Ramboer, Isabelle, Cahill, Conor P, Lievens, Marc, Dubois, Marie-Claude, Demoitie, Marie-Ange, Leach, Amanda, Cohen, Joe, Ballou, W Ripley, Heppner, Jr, D Gray
Published in PloS one (31.07.2009)
Published in PloS one (31.07.2009)
Get full text
Journal Article
Clinical development of a recombinant Ebola vaccine in the midst of an unprecedented epidemic
Coller, Beth-Ann G, Blue, Jeffrey, Das, Rituparna, Dubey, Sheri, Finelli, Lynn, Gupta, Swati, Helmond, Frans, Grant-Klein, Rebecca J, Liu, Kenneth, Simon, Jakub, Troth, Sean, VanRheenen, Susan, Waterbury, Julie, Wivel, Ashley, Wolf, Jayanthi, Heppner, D. Gray, Kemp, Tracy, Nichols, Rick, Monath, Thomas P
Published in Vaccine (16.08.2017)
Published in Vaccine (16.08.2017)
Get full text
Journal Article
Molecular Basis of Allele-Specific Efficacy of a Blood-Stage Malaria Vaccine: Vaccine Development Implications
Ouattara, Amed, Takala-Harrison, Shannon, Thera, Mahamadou A., Coulibaly, Drissa, Niangaly, Amadou, Saye, Renion, Tolo, Youssouf, Dutta, Sheetij, Heppner, D. Gray, Soisson, Lorraine, Diggs, Carter L., Vekemans, Johan, Cohen, Joe, Blackwelder, William C., Dube, Tina, Laurens, Matthew B., Doumbo, Ogobara K., Plowe, Christopher V.
Published in The Journal of infectious diseases (01.02.2013)
Published in The Journal of infectious diseases (01.02.2013)
Get full text
Journal Article
Protection of Humans against Malaria by Immunization with Radiation-Attenuated Plasmodium falciparum Sporozoites
Hoffman, Stephen L., Goh, Lucy M. L., Luke, Thomas C., Schneider, Imogene, Le, Thong P., Doolan, Denise L., Sacci, John, de la Vega, Patricia, Dowler, Megan, Paul, Chris, Gordon, Daniel M., Stoute, Jose A., Church, L. W. Preston, Sedegah, Martha, Heppner, D. Gray, Ballou, W. Ripley, Richie, Thomas L.
Published in The Journal of infectious diseases (15.04.2002)
Published in The Journal of infectious diseases (15.04.2002)
Get full text
Journal Article
Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway
Pichyangkul, Sathit, Yongvanitchit, Kosol, Kum-arb, Utaiwan, Hemmi, Hiroaki, Akira, Shizuo, Krieg, Arthur M, Heppner, D. Gray, Stewart, V. Ann, Hasegawa, Hitoshi, Looareesuwan, Sornchai, Shanks, G. Dennis, Miller, R. Scott
Published in The Journal of immunology (1950) (15.04.2004)
Published in The Journal of immunology (1950) (15.04.2004)
Get full text
Journal Article
Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy, malaria naïve adults
Kester, Kent E, Gray Heppner, D, Moris, Philippe, Ofori-Anyinam, Opokua, Krzych, Urszula, Tornieporth, Nadia, McKinney, Denise, Delchambre, Martine, Ockenhouse, Christian F, Voss, Gerald, Holland, Carolyn, Beckey, Jolie Palensky, Ballou, W. Ripley, Cohen, Joe
Published in Vaccine (20.11.2014)
Published in Vaccine (20.11.2014)
Get full text
Journal Article
Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine
Vahey, Maryanne T., Wang, Zhining, Kester, Kent E., Cummings, James, Heppner, D. Gray, Nau, Martin E., Ofori-Anyinam, Opokua, Cohen, Joe, Coche, Thierry, Ballou, W. Ripley, Ockenhouse, Christian F.
Published in The Journal of infectious diseases (15.02.2010)
Published in The Journal of infectious diseases (15.02.2010)
Get full text
Journal Article
Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya
Ogutu, Bernhards R, Apollo, Odika J, McKinney, Denise, Okoth, Willis, Siangla, Joram, Dubovsky, Filip, Tucker, Kathryn, Waitumbi, John N, Diggs, Carter, Wittes, Janet, Malkin, Elissa, Leach, Amanda, Soisson, Lorraine A, Milman, Jessica B, Otieno, Lucas, Holland, Carolyn A, Polhemus, Mark, Remich, Shon A, Ockenhouse, Christian F, Cohen, Joe, Ballou, W Ripley, Martin, Samuel K, Angov, Evelina, Stewart, V Ann, Lyon, Jeffrey A, Heppner, D Gray, Withers, Mark R
Published in PloS one (05.03.2009)
Published in PloS one (05.03.2009)
Get full text
Journal Article
A phase IIa, randomized, double-blind, safety, immunogenicity and efficacy trial of Plasmodium falciparum vaccine antigens merozoite surface protein 1 and RTS,S formulated with AS02 adjuvant in healthy, malaria-naïve adults
Cummings, J.F., Polhemus, M.E., Kester, K.E., Ockenhouse, C.F., Gasser, R.A., Coyne, P., Wortmann, G., Nielsen, R.K., Schaecher, K., Holland, C.A., Krzych, U., Tornieporth, N., Soisson, L.A., Angov, E., Heppner, D.G.
Published in Vaccine (30.04.2024)
Published in Vaccine (30.04.2024)
Get full text
Journal Article
Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research
Heppner, D. Gray, Kester, Kent E., Ockenhouse, Christian F., Tornieporth, Nadia, Ofori, Opokua, Lyon, Jeffrey A., Stewart, V. Ann, Dubois, Patrice, Lanar, David E., Krzych, Urszula, Moris, Philippe, Angov, Evelina, Cummings, James F., Leach, Amanda, Hall, B. Ted, Dutta, Sheetij, Schwenk, Robert, Hillier, Collette, Barbosa, Arnoldo, Ware, Lisa A., Nair, Lalitha, Darko, Christian A., Withers, Mark R., Ogutu, Bernhards, Polhemus, Mark E., Fukuda, Mark, Pichyangkul, Sathit, Gettyacamin, Montip, Diggs, Carter, Soisson, Lorraine, Milman, Jessica, Dubois, Marie-Claude, Garçon, Nathalie, Tucker, Kathryn, Wittes, Janet, Plowe, Christopher V., Thera, Mahamadou A., Duombo, Ogobara K., Pau, Maria G., Goudsmit, Jaap, Ballou, W. Ripley, Cohen, Joe
Published in Vaccine (18.03.2005)
Published in Vaccine (18.03.2005)
Get full text
Journal Article
Conference Proceeding
rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/benefit assessment
Monath, Thomas P, Fast, Patricia E, Modjarrad, Kayvon, Clarke, David K, Martin, Brian K, Fusco, Joan, Nichols, Richard, Heppner, D Gray, Simon, Jakub K, Dubey, Sheri, Troth, Sean P, Wolf, Jayanthi, Singh, Vidisha, Coller, Beth-Ann, Robertson, James S
Published in Vaccine: X (11.04.2019)
Published in Vaccine: X (11.04.2019)
Get full text
Journal Article
Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells
Lumsden, Joanne M, Schwenk, Robert J, Rein, Lisa E, Moris, Philippe, Janssens, Michel, Ofori-Anyinam, Opokua, Cohen, Joe, Kester, Kent E, Heppner, D Gray, Krzych, Urszula
Published in PloS one (2011)
Published in PloS one (2011)
Get full text
Journal Article
Randomized Trial of 3-Dose Regimens of Tafenoquine (WR238605) versus Low-Dose Primaquine for Preventing Plasmodium vivax Malaria Relapse
Walsh, Douglas S., Wilairatana, Polrat, Tang, Douglas B., Heppner, D. Gray, Brewer, Thomas G., Krudsood, Srivicha, Silachamroon, Udomsak, Phumratanaprapin, Weerapong, Siriyanonda, Duangsuda, Looareesuwan, Sornchai
Published in Clinical infectious diseases (15.10.2004)
Published in Clinical infectious diseases (15.10.2004)
Get full text
Journal Article
Priming with an Adenovirus 35-Circumsporozoite Protein (CS) Vaccine followed by RTS,S/AS01B Boosting Significantly Improves Immunogenicity to Plasmodium falciparum CS Compared to That with Either Malaria Vaccine Alone
STEWART, V. Ann, MCGRATH, Shannon M, DEMOITIE, Marie-Ange, JAN WEVERLING, Gerrit, BAYAT, Babak, CUSTERS, Jerome H. H. V, DUBOIS, Marie-Claude, COHEN, Joe, GOUDSMIT, Jaap, GRAY HEPPNER, D, DUBOIS, Patrice M, PAU, Maria G, METTENS, Pascal, SHOTT, Joseph, COBB, Michelle, BURGE, J. Robert, LARSON, David, WARE, Lisa A
Published in Infection and Immunity (01.05.2007)
Published in Infection and Immunity (01.05.2007)
Get full text
Journal Article