Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification
Brewitz, Lennart, Henry Chan, H T, Lukacik, Petra, Strain-Damerell, Claire, Walsh, Martin A, Duarte, Fernanda, Schofield, Christopher J
Published in Bioorganic & medicinal chemistry (15.11.2023)
Published in Bioorganic & medicinal chemistry (15.11.2023)
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Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M pro inhibitors
Malla, Tika R, Tumber, Anthony, John, Tobias, Brewitz, Lennart, Strain-Damerell, Claire, Owen, C David, Lukacik, Petra, Chan, H T Henry, Maheswaran, Pratheesh, Salah, Eidarus, Duarte, Fernanda, Yang, Haitao, Rao, Zihe, Walsh, Martin A, Schofield, Christopher J
Published in Chemical communications (Cambridge, England) (15.02.2021)
Published in Chemical communications (Cambridge, England) (15.02.2021)
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Journal Article
Discovery of SARS-CoV-2 M pro peptide inhibitors from modelling substrate and ligand binding
Chan, H T Henry, Moesser, Marc A, Walters, Rebecca K, Malla, Tika R, Twidale, Rebecca M, John, Tobias, Deeks, Helen M, Johnston-Wood, Tristan, Mikhailov, Victor, Sessions, Richard B, Dawson, William, Salah, Eidarus, Lukacik, Petra, Strain-Damerell, Claire, Owen, C David, Nakajima, Takahito, Świderek, Katarzyna, Lodola, Alessio, Moliner, Vicent, Glowacki, David R, Spencer, James, Walsh, Martin A, Schofield, Christopher J, Genovese, Luigi, Shoemark, Deborah K, Mulholland, Adrian J, Duarte, Fernanda, Morris, Garrett M
Published in Chemical science (Cambridge) (27.10.2021)
Published in Chemical science (Cambridge) (27.10.2021)
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Journal Article
Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism
Aertker, Kristina M.J., Chan, H.T. Henry, Lohans, Christopher T., Schofield, Christopher J.
Published in The Journal of biological chemistry (04.12.2020)
Published in The Journal of biological chemistry (04.12.2020)
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Journal Article
Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants
Lohans, Christopher T., Chan, H. T. Henry, Malla, Tika R., Kumar, Kiran, Kamps, Jos J. A. G., McArdle, Darius J. B., van Groesen, Emma, de Munnik, Mariska, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.
Published in Angewandte Chemie International Edition (11.02.2019)
Published in Angewandte Chemie International Edition (11.02.2019)
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Journal Article
Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV‑2 Main Protease
Chan, H. T. Henry, Oliveira, A. Sofia F., Schofield, Christopher J., Mulholland, Adrian J., Duarte, Fernanda
Published in JACS Au (26.06.2023)
Published in JACS Au (26.06.2023)
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Journal Article
Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2′ proline of the viral polyprotein
Chan, H. T. Henry, Brewitz, Lennart, Lukacik, Petra, Strain-Damerell, Claire, Walsh, Martin A, Schofield, Christopher J, Duarte, Fernanda
Published in RSC chemical biology (07.02.2024)
Published in RSC chemical biology (07.02.2024)
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Journal Article
Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding
Chan, H T Henry, Moesser, Marc A, Walters, Rebecca K, Malla, Tika R, Twidale, Rebecca M, Tobias, John, Deeks, Helen M, Johnston-Wood, Tristan, Mikhailov, Victor, Sessions, Richard B, Dawson, William, Eidarus Salah, Lukacik, Petra, Strain-Damerell, Claire, Owen, C David, Nakajima, Takahito, Świderek, Katarzyna, Lodola, Alessio, Moliner, Vicent, Glowacki, David R, Spencer, James, Walsh, Martin A, Schofield, Christopher J, Genovese, Luigi, Shoemark, Deborah K, Mulholland, Adrian J, Duarte, Fernanda, Morris, Garrett M
Published in Chemical science (Cambridge) (27.10.2021)
Published in Chemical science (Cambridge) (27.10.2021)
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Journal Article
Voltammetry using multiple cycles: Porous electrodes
Chan, Henry T.H., Kätelhön, Enno, Compton, Richard G.
Published in Journal of electroanalytical chemistry (Lausanne, Switzerland) (15.08.2017)
Published in Journal of electroanalytical chemistry (Lausanne, Switzerland) (15.08.2017)
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Journal Article
Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants
Lohans, Christopher T., Chan, H. T. Henry, Malla, Tika R., Kumar, Kiran, Kamps, Jos J. A. G., McArdle, Darius J. B., van Groesen, Emma, de Munnik, Mariska, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.
Published in Angewandte Chemie (11.02.2019)
Published in Angewandte Chemie (11.02.2019)
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Polydopamine Modified Activated Carbon for Capacitive Desalination
Xie, Zhengzheng, Cheng, Jian, Yan, Junbin, Cai, Wenshu, Nie, Pengfei, Chan, Henry T. H., Liu, Jianyun
Published in Journal of the Electrochemical Society (01.01.2017)
Published in Journal of the Electrochemical Society (01.01.2017)
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Journal Article
Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors
Malla, Tika R, Tumber, Anthony, Tobias, John, Brewitz, Lennart, Strain-Damerell, Claire, Owen, C David, Lukacik, Petra, Chan, H T Henry, Maheswaran, Pratheesh, Eidarus Salah, Duarte, Fernanda, Yang, Haitao, Rao, Zihe, Walsh, Martin A, Schofield, Christopher J
Published in Chemical communications (Cambridge, England) (15.02.2021)
Published in Chemical communications (Cambridge, England) (15.02.2021)
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Journal Article
Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors† †Electronic supplementary information (ESI) available: Experimental details and inhibition data. See DOI: 10.1039/d0cc06870e
Malla, Tika R., Tumber, Anthony, John, Tobias, Brewitz, Lennart, Strain-Damerell, Claire, Owen, C David, Lukacik, Petra, Chan, H. T. Henry, Maheswaran, Pratheesh, Salah, Eidarus, Duarte, Fernanda, Yang, Haitao, Rao, Zihe, Walsh, Martin A., Schofield, Christopher J.
Published in Chemical communications (Cambridge, England) (19.01.2021)
Published in Chemical communications (Cambridge, England) (19.01.2021)
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Journal Article
Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism
Aertker, Kristina M J, Chan, H T Henry, Lohans, Christopher T, Schofield, Christopher J
Published in The Journal of biological chemistry (04.12.2020)
Get full text
Published in The Journal of biological chemistry (04.12.2020)
Journal Article
Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M inhibitors
Malla, Tika R, Tumber, Anthony, John, Tobias, Brewitz, Lennart, Strain-Damerell, Claire, Owen, C David, Lukacik, Petra, Chan, H. T. Henry, Maheswaran, Pratheesh, Salah, Eidarus, Duarte, Fernanda, Yang, Haitao, Rao, Zihe, Walsh, Martin A, Schofield, Christopher J
Published in Chemical communications (Cambridge, England) (15.02.2021)
Published in Chemical communications (Cambridge, England) (15.02.2021)
Get full text
Journal Article
Discovery of SARS-CoV-2 M peptide inhibitors from modelling substrate and ligand binding
Chan, H. T. Henry, Moesser, Marc A, Walters, Rebecca K, Malla, Tika R, Twidale, Rebecca M, John, Tobias, Deeks, Helen M, Johnston-Wood, Tristan, Mikhailov, Victor, Sessions, Richard B, Dawson, William, Salah, Eidarus, Lukacik, Petra, Strain-Damerell, Claire, Owen, C. David, Nakajima, Takahito, widerek, Katarzyna, Lodola, Alessio, Moliner, Vicent, Glowacki, David R, Spencer, James, Walsh, Martin A, Schofield, Christopher J, Genovese, Luigi, Shoemark, Deborah K, Mulholland, Adrian J, Duarte, Fernanda, Morris, Garrett M
Published in Chemical science (Cambridge) (27.10.2021)
Published in Chemical science (Cambridge) (27.10.2021)
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Journal Article
Substrate recognition and selectivity in SARS-CoV-2 main protease: Unveiling the role of subsite interactions through dynamical nonequilibrium molecular dynamics simulations
Chan, H T Henry, Oliveira, A Sofia F, Mulholland, Adrian J, Schofield, Christopher J, Duarte, Fernanda
Published in bioRxiv (03.12.2023)
Published in bioRxiv (03.12.2023)
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Paper
Dynamical nonequilibrium molecular dynamics simulations identify allosteric sites and positions associated with drug resistance in the SARS-CoV-2 main protease
Chan, H T Henry, Oliveira, A Sofia F, Schofield, Christopher J, Mulholland, Adrian J, Duarte, Fernanda
Published in bioRxiv (14.12.2022)
Published in bioRxiv (14.12.2022)
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Paper
Discovery of SARS-CoV-2 Mpro Peptide Inhibitors from Modelling Substrate and Ligand Binding
Chan, H T Henry, Moesser, Marc A, Walters, Rebecca K, Malla, Tika R, Twidale, Rebecca M, Tobias, John, Deeks, Helen M, Johnston-Wood, Tristan, Mikhailov, Victor, Sessions, Richard B, Dawson, William, Eidarus Salah, Lukacik, Petra, Strain-Damerell, Claire, Owen, David, Nakajima, Takahito, Swiderek, Katarzyna, Lodola, Alessio, Moliner, Vicent, Glowacki, David R, Walsh, Martin A, Schofield, Christopher J, Genovese, Luigi, Shoemark, Deborah, Mulholland, Adrian J, Duarte, Fernanda, Morris, Garrett M
Published in bioRxiv (19.06.2021)
Published in bioRxiv (19.06.2021)
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Paper