Synthesis and Pharmacological Characterization of C4‑(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)‑2-Amino-4-(1H‑1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist
Monn, James A, Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R, Henry, Steven S, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Getman, Brian G, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Synthesis and Pharmacological Characterization of C4 β -Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu 3 Receptor Agonist
Monn, James A, Henry, Steven S, Massey, Steven M, Clawson, David K, Chen, Qi, Diseroad, Benjamin A, Bhardwaj, Rajni M, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xu-Shan, Carter, Joan H, Getman, Brian G, Adragni, Kofi, Broad, Lisa M, Sanger, Helene E, Ursu, Daniel, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L, Hao, Junliang
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S‑2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
Monn, James A, Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R, Henry, Steven S, Goldsmith, Paul J, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Xiang, Chuanxi, Catlow, John T, Swanson, Steven, Sanger, Helen, Broad, Lisa M, Johnson, Michael P, Knopp, Kelly L, Simmons, Rosa M. A, Johnson, Bryan G, Shaw, David B, McKinzie, David L
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Synthesis and Pharmacological Characterization of 4‑Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor Agonists
Monn, James A, Valli, Matthew J, Massey, Steven M, Hao, Junliang, Reinhard, Matthew R, Bures, Mark G, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Getman, Brian G, Stephenson, Gregory A, Herin, Marc, Catlow, John T, Swanson, Steven, Johnson, Bryan G, McKinzie, David L, Henry, Steven S
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Simple conversion of fully protected amino acids to zwitterions
Hao, Junliang, Reinhard, Matt, Henry, Steven S., Seest, Eric P., Belvo, Matthew D., Monn, James A.
Published in Tetrahedron letters (21.03.2012)
Published in Tetrahedron letters (21.03.2012)
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Improved Synthesis of C4α- and C4β-Methyl Analogues of 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate
Henry, Steven S, Brady, Molly D, Laird, Dana L. T, Ruble, J. Craig, Varie, David L, Monn, James A
Published in Organic letters (01.06.2012)
Published in Organic letters (01.06.2012)
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Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: Identification of Potent, Selective, and Orally Bioavailable Agonists for mGlu2/3 Receptors
Monn, James A., Massey, Steven M., Valli, Matthew J., Henry, Steven S., Stephenson, Gregory A., Bures, Mark, Hérin, Marc, Catlow, John, Giera, Deborah, Wright, Rebecca A., Johnson, Bryan G., Andis, Sherri L., Kingston, Ann, Schoepp, Darryle D.
Published in Journal of medicinal chemistry (25.01.2007)
Published in Journal of medicinal chemistry (25.01.2007)
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Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator
Hao, Junliang, Dehlinger, Veronique, Fivush, Adam M., Rudyk, Helene C.E., Britton, Thomas C., Hollinshead, Sean P., Vokits, Benjamin P., Clark, Barry P., Henry, Steven S., Massey, Steven M., Peng, Langu, Dressman, Bruce A., Heinz, Beverly A., Roberts, Edda F., Bracey-Walker, Mallorie R., Swanson, Steven, Catlow, John T., Love, Patrick L., Tepool, Anita D., Peters, Steven C., Simmons, Rosa Maria A., Iyengar, Smriti, McKinzie, David L., Monn, James A.
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)- N-(3-pyridinylmethyl)ethanesulfonamide
Barda, David A., Wang, Zhao-Qing, Britton, Thomas C., Henry, Steven S., Jagdmann, G.Erik, Coleman, Darrell S., Johnson, Michael P., Andis, Sherri L., Schoepp, Darryle D.
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Asymmetric Synthesis of the Key Intermediates Leading to (-)-Aphanorphine and (-)-Eptazocine
Hulme, Alison N, Henry, Steven S, Meyers, A. I
Published in Journal of organic chemistry (01.03.1995)
Published in Journal of organic chemistry (01.03.1995)
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Synthesis and Pharmacological Characterization of C4(beta)-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist
Monn, James A., Henry, Steven S., Massey, Steven M., Clawson, David K., Chen, Qi, Diseroad, Benjamin A., Bhardwaj, Rajni M., Atwel, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xu-shan, Carter, Joan H., Getman, Brian G., Adragni, Kofi, Broad, Lisa M., Sanger, Helene E., Ursu, Daniel, Catlow, John T., Swanson, Steven, Johnson, Bryan G., Shaw, David B., McKinzie, David L., Hao, Junliang
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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Journal Article
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu(2) Receptor Agonist
Monn, James A., Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R., Hen, Steven S., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Getman, Brian G., Catlow, John T., Swanson, Steven, Johnson, Bryan G., Shaw, David B., McKinzie, David L.
Published in Journal of medicinal chemistry (18.03.2016)
Published in Journal of medicinal chemistry (18.03.2016)
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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1 S ,2 S ,5 R ,6 S -2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
Monn, James A., Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R., Henry, Steven S., Goldsmith, Paul J., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Xiang, Chuanxi, Catlow, John T., Swanson, Steven, Sanger, Helen, Broad, Lisa M., Johnson, Michael P., Knopp, Kelly L., Simmons, Rosa M. A., Johnson, Bryan G., Shaw, David B., McKinzie, David L.
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Synthesis strategies for marine diterpenes. Total synthesis of the clavularanes
Williams, David R, Coleman, Paul J, Henry, Steven S
Published in Journal of the American Chemical Society (01.12.1993)
Published in Journal of the American Chemical Society (01.12.1993)
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Synthesis and Pharmacological Characterization of C4β‑Amide-Substituted 2‑Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)‑2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist
Monn, James A, Henry, Steven S, Massey, Steven M, Clawson, David K, Chen, Qi, Diseroad, Benjamin A, Bhardwaj, Rajni M, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xu-shan, Carter, Joan H, Getman, Brian G, Adragni, Kofi, Broad, Lisa M, Sanger, Helene E, Ursu, Daniel, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L, Hao, Junliang
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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ChemInform Abstract: Simple Conversion of Fully Protected Amino Acids to Zwitterions
Hao, Junliang, Reinhard, Matt, Henry, Steven S., Seest, Eric P., Belvo, Matthew D., Monn, James A.
Published in ChemInform (10.07.2012)
Published in ChemInform (10.07.2012)
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Journal Article
Synthesis and Pharmacological Characterization of C 4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 R ,2 S ,4 R ,5 R ,6 R )-2-Amino-4-(1 H -1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu 2 Receptor Agonist
Monn, James A., Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R., Henry, Steven S., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Getman, Brian G., Catlow, John T., Swanson, Steven, Johnson, Bryan G., Shaw, David B., McKinzie, David L.
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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SOCIAL NETWORK DATA PROCESSING AND PROFILING
INFANT ADO, RICHARD M, VELASCO, VON ROLFE B, RUIZ,PETER, CRUZ, NEPTHALIE P, SY, HENRY STEVEN T, CABACUNGAN, DARYL CHRISTIAN M
Year of Publication 23.07.2018
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Year of Publication 23.07.2018
Patent
SOCIAL NETWORK DATA PROCESSING AND PROFILING
INFANT ADO, RICHARD M, VELASCO, VON ROLFE B, RUIZ,PETER, CRUZ, NEPTHALIE P, SY, HENRY STEVEN T, CABACUNGAN, DARYL CHRISTIAN M
Year of Publication 23.07.2018
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Year of Publication 23.07.2018
Patent