The Discovery of 7‑Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)‑N‑(6-methylpyrazolo[1,5‑a]pyrimidin-3-yl)imidazo[1,2‑a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke
Evans, Ryan, Bolduc, Philippe N., Pfaffenbach, Magnus, Gao, Fang, May-Dracka, Tricia, Fang, Terry, Hopkins, Brian T., Chodaparambil, Jayanth V, Henry, Kate L., Li, Pei, Metrick, Claire, Nelson, Ashley, Trapa, Patrick, Thomas, Ankur, Burkly, Linda, Peterson, Emily A.
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Discovery of BIO-8169A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation
Pfaffenbach, Magnus, Bolduc, Philippe N., Xin, Zhili, Gao, Fang, Evans, Ryan, Fang, Terry, Chodaparambil, Jayanth V., Henry, Kate L., Li, Pei, Mathieu, Steven, Metrick, Claire, Vera Rebollar, Jorge A., Gu, Rong-Fang, Mccarl, Christie-Ann, Silbereis, John, Peterson, Emily A.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors
Bolduc, Philippe N., Pfaffenbach, Magnus, Evans, Ryan, Xin, Zhili, Henry, Kate L., Gao, Fang, Fang, Terry, Silbereis, John, Vera Rebollar, Jorge, Li, Pei, Chodaparambil, Jayanth V, Metrick, Claire, Peterson, Emily A.
Published in ACS medicinal chemistry letters (09.05.2024)
Published in ACS medicinal chemistry letters (09.05.2024)
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CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling
Henry, Kate L, Kellner, Debra, Bajrami, Bekim, Anderson, John E, Beyna, Mercedes, Bhisetti, Govinda, Cameron, Tom, Capacci, Andrew G, Bertolotti-Ciarlet, Andrea, Feng, Jun, Gao, Benbo, Hopkins, Brian, Jenkins, Tracy, Li, Kejie, May-Dracka, Tricia, Murugan, Paramasivam, Wei, Ru, Zeng, Weike, Allaire, Norm, Buckler, Alan, Loh, Christine, Juhasz, Peter, Lucas, Brian, Ennis, Katelin A, Vollman, Elisabeth, Cahir-McFarland, Ellen, Hett, Erik C, Ols, Michelle L
Published in Science signaling (31.07.2018)
Published in Science signaling (31.07.2018)
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Transfusion of murine red blood cells expressing the human KEL glycoprotein induces clinically significant alloantibodies
Stowell, Sean R., Girard-Pierce, Kathryn R., Smith, Nicole H., Henry, Kate L., Arthur, C. Maridith, Zimring, James C., Hendrickson, Jeanne E.
Published in Transfusion (Philadelphia, Pa.) (01.01.2014)
Published in Transfusion (Philadelphia, Pa.) (01.01.2014)
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Generation of transgenic mice with antithetical KEL1 and KEL2 human blood group antigens on red blood cells
Smith, Nicole H., Henry, Kate L., Cadwell, Chantel M., Bennett, Ashley, Hendrickson, Jeanne E., Frame, Tom, Zimring, James C.
Published in Transfusion (Philadelphia, Pa.) (01.12.2012)
Published in Transfusion (Philadelphia, Pa.) (01.12.2012)
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Recombinant factor VIII Fc fusion protein drives regulatory macrophage polarization
Kis-Toth, Katalin, Rajani, Gaurav Manohar, Simpson, Allison, Henry, Kate L., Dumont, Jennifer, Peters, Robert T., Salas, Joe, Loh, Christine
Published in Blood advances (13.11.2018)
Published in Blood advances (13.11.2018)
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Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine model
Stowell, Sean R., Henry, Kate L., Smith, Nicole H., Hudson, Krystalyn E., Halverson, Greg R., Park, Jaekeun C., Bennett, Ashley M., Girard-Pierce, Kathryn R., Arthur, C. Maridith, Bunting, Silvia T., Zimring, James C., Hendrickson, Jeanne E.
Published in Blood (22.08.2013)
Published in Blood (22.08.2013)
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Development of a Murine Model of Weak Kel: Similarities to Weak Rh(D)
Hendrickson, Jeanne E., Smith, Nicole H., Girard-Pierce, Kathryn R., Tormey, Christopher A, Henry, Kate L., Zimring, James C., Stowell, Sean R.
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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Transfusion of murine RBCs expressing the human KEL glycoprotein induces clinically significant alloantibodies
Stowell, Sean R., Girard-Pierce, Kathryn R., Smith, Nicole H., Henry, Kate L., Arthur, C. Maridith, Zimring, James C., Hendrickson, Jeanne E.
Published in Transfusion (Philadelphia, Pa.) (29.04.2013)
Published in Transfusion (Philadelphia, Pa.) (29.04.2013)
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