Rational-Based Discovery of Novel β-Carboline Derivatives as Potential Antimalarials: From In Silico Identification of Novel Targets to Inhibition of Experimental Cerebral Malaria
Alves, Fernanda de Moura, Bellei, Jessica Correa Bezerra, Barbosa, Camila de Souza, Duarte, Caíque Lopes, Fonseca, Amanda Luisa da, Pinto, Ana Claudia de Souza, Raimundo, Felipe Oliveira, Carpinter, Bárbara Albuquerque, Lemos, Ari Sérgio de Oliveira, Coimbra, Elaine Soares, Taranto, Alex Gutterres, Rocha, Vinícius Novaes, de Pilla Varotti, Fernando, Ribeiro Viana, Gustavo Henrique, Scopel, Kézia K G
Published in Pathogens (Basel) (01.12.2022)
Published in Pathogens (Basel) (01.12.2022)
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Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate
de Oliveira, Michael Eder, Cenzi, Gisele, Nunes, Renata Rachide, Andrighetti, Carla Regina, de Sousa Valadão, Denia Mendes, Dos Reis, Cláudia, Simões, Cláudia Maria Oliveira, Nunes, Ricardo José, Júnior, Moacyr Comar, Taranto, Alex Gutterres, Sanchez, Bruno Antonio Marinho, Viana, Gustavo Henrique Ribeiro, de Pilla Varotti, Fernando
Published in Molecules (Basel, Switzerland) (10.12.2013)
Published in Molecules (Basel, Switzerland) (10.12.2013)
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Target-Guided Synthesis and Antiplasmodial Evaluation of a New Fluorinated 3‑Alkylpyridine Marine Alkaloid Analog
Barbosa, Camila de Souza, Guimarães, Daniel Silqueira Martins, Gonçalves, Alessandra Mirtes Marques Neves, Barbosa, Maria Cristina da Silva, Alves e Costa, Marília Ladeira, Nascimento Júnior, Clébio Soares, Guimarães, Luciana, Ribeiro-Viana, Renato Márcio, dos Santos, Fabio Vieira, Alves de Brito, Cristiana Ferreira, de Pilla Varotti, Fernando, Ribeiro Viana, Gustavo Henrique
Published in ACS omega (30.11.2017)
Published in ACS omega (30.11.2017)
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Nanoemulsion composed of 10-(4,5-dihydrothiazol-2-yl)thio)decan-1-ol), a synthetic analog of 3-alkylpiridine marine alkaloid: development, characterization, and antimalarial activity
Silva, Marina Goulart Da, Cardoso, Jéssica Ferreira, Perasoli, Fernanda Barçante, Branquinho, Renata Tupinambá, Mourão, Renata Silva, Tavares, Harley Da Silva, Xocaira, Maria Luiza Costa Trench, Guimarães, Daniel Silqueira Martins, Viana, Gustavo Henrique Ribeiro, Varotti, Fernando De Pilla, Silva, Gisele Rodrigues Da
Published in European journal of pharmaceutical sciences (01.08.2020)
Published in European journal of pharmaceutical sciences (01.08.2020)
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New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo
Soares, Roberta Reis, da Silva, José Marcio Fernandes, Carlos, Bianca Cecheto, da Fonseca, Camila Campos, de Souza, Laila Salomé Araújo, Lopes, Fernanda Valério, de Paula Dias, Rafael Mafra, Moreira, Paulo Otávio Lourenço, Abramo, Clarice, Viana, Gustavo Henrique Ribeiro, de Pila Varotti, Fernando, da Silva, Adilson David, Scopel, Kézia Katiani Gorza
Published in Bioorganic & medicinal chemistry letters (01.06.2015)
Published in Bioorganic & medicinal chemistry letters (01.06.2015)
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Metabolic activation enhances the cytotoxicity, genotoxicity and mutagenicity of two synthetic alkaloids with selective effects against human tumour cell lines
Oliveira, Júlia Teixeira de, Franco, Filipe Nogueira, Tecchio, Kimberly Brito, Gonçalves, Alessandra Mirtes Marques Neves, Barbosa, Camila de Souza, Ribeiro, Rosy Iara Maciel de Azambuja, Viana, Gustavo Henrique Ribeiro, Santos, Vanessa J. da Silva Vieira dos, Santos, Fabio Vieira dos
Published in Mutation research (01.01.2021)
Published in Mutation research (01.01.2021)
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Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability
Guimarães, Daniel Silqueira Martins, de Sousa Luz, Letícia Silveira, do Nascimento, Sara Batista, Silva, Lorena Rabelo, de Miranda Martins, Natália Rezende, de Almeida, Heloísa Gonçalves, de Souza Reis, Vitória, Maluf, Sarah El Chamy, Budu, Alexandre, Marinho, Juliane Aparecida, Abramo, Clarice, Carmona, Adriana Karaoglanovic, da Silva, Marina Goulart, da Silva, Gisele Rodrigues, Kemmer, Victor Matheus, Butera, Anna Paola, Ribeiro-Viana, Renato Márcio, Gazarini, Marcos Leoni, Júnior, Clébio Soares Nascimento, Guimarães, Luciana, dos Santos, Fabio Vieira, de Castro, Whocely Victor, Viana, Gustavo Henrique Ribeiro, de Brito, Cristiana Ferreira Alves, de Pilla Varotti, Fernando
Published in European journal of pharmaceutical sciences (01.10.2019)
Published in European journal of pharmaceutical sciences (01.10.2019)
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Synthetic 3-alkylpyridine alkaloid analogues as a new scaffold against leukemic cell lines: cytotoxic evaluation and mode of action
Evangelista, Fernanda Cristina Gontijo, de Freitas Lopes, Aline, Andrade, Silmara Nunes, de Souza Barbosa, Camila, da Silva, Julia Dias, Neves, Alessandra Mirtes Marques, de Mello Gomide Loures, Cristina, Brito, Larissa Froede, de Sousa, Lirlândia Pires, Borges, Karina Braga Gomes, Viana, Gustavo Henrique Ribeiro, de Pilla Varotti, Fernando, de Paula Sabino, Adriano
Published in Medicinal chemistry research (01.09.2019)
Published in Medicinal chemistry research (01.09.2019)
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Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity
Gonçalves, Alessandra Mirtes Marques Neves, de Lima, Aline Brito, da Silva Barbosa, Maria Cristina, de Camargos, Luiz Fernando, de Oliveira, Júlia Teixeira, de Souza Barbosa, Camila, Villar, José Augusto Ferreira Perez, Costa, André Carvalho, Silva, Isabella Viana Gomes da, Silva, Luciana Maria, de Pilla Varotti, Fernando, dos Santos, Fabio Vieira, Viana, Gustavo Henrique Ribeiro
Published in Marine drugs (31.07.2014)
Published in Marine drugs (31.07.2014)
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Long-chain alkyltriazoles as antitumor agents: synthesis, physicochemical properties, and biological and computational evaluation
Gontijo, Vanessa Silva, Oliveira, Michael Éder, Resende, Rafael José, Fonseca, Amanda Luisa, Nunes, Renata Rachide, Júnior, Moacyr Comar, Taranto, Alex Gutterres, Torres, Natalia Machado Pereira Oliveira, Viana, Gustavo Henrique Ribeiro, Silva, Luciana Maria, Alves, Rosemeire Brondi, Varotti, Fernando Pilla, Freitas, Rossimiriam Pereira
Published in Medicinal chemistry research (2015)
Published in Medicinal chemistry research (2015)
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Synthesis and evaluation of antimalarial activity of curcumin derivatives
Gomes, Patrícia Ramos, Miguel, Fábio Balbino, Oliveira, Michael Éder de, Ferreira, Vanessa Viana, Guimarães, Daniel Silqueira Martins, Lima, Aline Brito de, Barbosa, Camila de Souza, Oliveira, Mariana Amorim de, Almeida, Mauro Vieira de, Viana, Gustavo Henrique Ribeiro, Couri, Mara Rubia Costa, Varotti, Fernando de Pilla
Published in Química nova (2014)
Published in Química nova (2014)
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Evaluation of the in vivo acute toxicity and in vitro genotoxicity and mutagenicity of synthetic β-carboline alkaloids with selective cytotoxic activity against ovarian and breast cancer cell lines
Tecchio, Kimberly Brito, Alves, Fernanda de Moura, Alves, Janaina Domingas, Barbosa, Camila de Souza, Salgado, Mariana Alves Rezende, Santos, Vanessa Jaqueline da Silva Vieira dos, Varotti, Fernando de Pilla, Campos-Junior, Paulo Henrique de Almeida, Viana, Gustavo Henrique Ribeiro, Santos, Fabio Vieira dos
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.10.2024)
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.10.2024)
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Design, synthesis, and biodistribution studies of new analogues of marine alkaloids: Potent in vitro and in vivo fungicidal agents against Candida spp
Andrade, Jéssica Tauany, Lima, William Gustavo, Sousa, Jaqueline França, Saldanha, Aline Aparecida, Nívea Pereira De Sá, Morais, Fernanda Barbara, Prates Silva, Mayra Karla, Ribeiro Viana, Gustavo Henrique, Johann, Susana, Soares, Adriana Cristina, Araújo, Leonardo Allan, Antunes Fernandes, Simone Odília, Cardoso, Valbert Nascimento, Siqueira Ferreira, Jaqueline Maria
Published in European journal of medicinal chemistry (15.01.2021)
Published in European journal of medicinal chemistry (15.01.2021)
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In vitro evaluation of the selective cytotoxicity and genotoxicity of three synthetic ortho -nitrobenzyl derivatives in human cancer cell lines, with and without metabolic activation
Teixeira De Oliveira, Júlia, Brito Tecchio, Kimberly, Silva Lopes, Marcela, Nunes Andrade, Silmara, Iara Maciel De Azambuja Ribeiro, Rosy, Varotti, Fernando De Pilla, Barbosa De Oliveira, Renata, Henrique Ribeiro Viana, Gustavo, J Da Silva Vieira Dos Santos, Vanessa, Vieira Dos Santos, Fabio
Published in Drug and chemical toxicology (New York, N.Y. 1978) (03.07.2024)
Published in Drug and chemical toxicology (New York, N.Y. 1978) (03.07.2024)
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Synthesis and evaluation of the mutagenicity of 3-alkylpyridine marine alkaloid analogues with anticancer potential
Barbosa, Maria Cristina S., de Souza Barbosa, Camila, de Oliveira, Júlia T., Moreira, Natália Chermont S., de Miranda Martins, Natália Rezende, Alves Gomes, Gabrielle K., Caldeira, Camila A., Alves e Costa, Marília Ladeira, Martins Guimarães, Daniel Silqueira, Guimarães, Luciana, Nascimento, Clebio S., de Pilla Varotti, Fernando, Ribeiro Viana, Gustavo Henrique, Santos, Fabio Vieira dos
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.01.2018)
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.01.2018)
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New 3‐alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD 44 +/high / CD 24 −/low subset of triple‐negative breast cancer cell line
de Lima, Aline Brito, Barbosa, Camila de Souza, Gonçalves, Alessandra Mirtes Marques Neves, Santos, Fabio Vieira dos, Viana, Gustavo Henrique Ribeiro, Varotti, Fernando de Pilla, Silva, Luciana Maria
Published in Chemical biology & drug design (01.07.2017)
Published in Chemical biology & drug design (01.07.2017)
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Journal Article
New 3‐alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44+/high/CD24−/low subset of triple‐negative breast cancer cell line
Lima, Aline Brito, Barbosa, Camila de Souza, Gonçalves, Alessandra Mirtes Marques Neves, Santos, Fabio Vieira dos, Viana, Gustavo Henrique Ribeiro, Varotti, Fernando de Pilla, Silva, Luciana Maria
Published in Chemical biology & drug design (01.07.2017)
Published in Chemical biology & drug design (01.07.2017)
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Journal Article
Halogenation as a Strategy to Improve Antiplasmodial Activity: A Report of New 3-Alkylpyridine Marine Alkaloid Analogs
de Souza Barbosa, Camila, Guimarães, Daniel Silqueira Martins, Costa Alves, Juliana da, de Brito, Cristiana Ferreira Alves, Ribeiro-Viana, Renato Márcio, de Pilla Varotti, Fernando, Ribeiro Viana, Gustavo Henrique
Published in International journal of travel medicine and global health (15.12.2019)
Published in International journal of travel medicine and global health (15.12.2019)
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Avaliação in silico e in vivo do perfil de metabolismo e toxicidade hepática de alcaloides β-carbolínicos sintéticos com prévia atividade antimalárica
Javert Pereira, Jorddan, Soares da Silva, Yulla, De Moura Alves, Fernanda, Martins Bellei, Pedro, Ribeiro Viana, Gustavo Henrique, Katiani Gorza Scopel, Kézia, Pires de Andrade, Bruno, Corrêa Bezerra Bellei, Jessica
Published in H.U. revista (06.02.2024)
Published in H.U. revista (06.02.2024)
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Antimalarial Activity of Zincke’s Salts
Machado, Matheus Vieira, Cenzi, Gisele, Nascimento, Maria Fernanda Alves, Paula, Renata Cristina de, Guimaraes, Daniel Silqueira Mar, Medeiros, Ana Carla, Alves, Rosemeire Brondi, Freitas, Rossimiriam Pereira, Varotti, Fernando de Pilla, Viana, Gustavo Henrique Rib
Published in Journal of biological sciences (Faisalabad, Pakistan) (2013)
Published in Journal of biological sciences (Faisalabad, Pakistan) (2013)
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