N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor
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Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
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AZD2171 : A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
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Published in Cancer research (Chicago, Ill.) (15.05.2005)
Published in Cancer research (Chicago, Ill.) (15.05.2005)
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Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530
Green, Tim P., Fennell, Mike, Whittaker, Robin, Curwen, Jon, Jacobs, Vivien, Allen, Jack, Logie, Armelle, Hargreaves, Judith, Hickinson, D. Mark, Wilkinson, Robert W., Elvin, Paul, Boyer, Brigitte, Carragher, Neil, Plé, Patrick A., Bermingham, Alun, Holdgate, Geoffrey A., Ward, Walter H.J., Hennequin, Laurent F., Davies, Barry R., Costello, Gerard F.
Published in Molecular oncology (01.06.2009)
Published in Molecular oncology (01.06.2009)
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Novel library synthesis of 3,4-disubstituted pyridin-2(1 H )-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature
Pierre, Romain, Brethon, Anne, Jacques, Sylvain A, Blond, Aurélie, Chambon, Sandrine, Talano, Sandrine, Raffin, Catherine, Musicki, Branislav, Bouix-Peter, Claire, Tomas, Loic, Ouvry, Gilles, Morgentin, Rémy, Hennequin, Laurent F, Harris, Craig S
Published in Beilstein journal of organic chemistry (2021)
Published in Beilstein journal of organic chemistry (2021)
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Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors
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Published in ACS medicinal chemistry letters (08.08.2013)
Published in ACS medicinal chemistry letters (08.08.2013)
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Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors
Hennequin, Laurent F, Thomas, Andrew P, Johnstone, Craig, Stokes, Elaine S. E, Plé, Patrick A, Lohmann, Jean-Jacques M, Ogilvie, Donald J, Dukes, Mike, Wedge, Steve R, Curwen, Jon O, Kendrew, Jane, Lambert-van der Brempt, Christine
Published in Journal of medicinal chemistry (30.12.1999)
Published in Journal of medicinal chemistry (30.12.1999)
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Inhibitors of epidermal growth factor receptor tyrosine kinase: Optimisation of potency and in vivo pharmacokinetics
Ballard, Peter, Bradbury, Robert H., Harris, Craig S., Hennequin, Laurent F.A., Hickinson, Mark, Kettle, Jason G., Kendrew, Jane, Klinowska, Teresa, Ogilvie, Donald J., Pearson, Stuart E., Williams, Emma J., Wilson, Ingrid
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase
Ballard, Peter, Barlaam, Bernard C., Bradbury, Robert H., Dishington, Allan, Hennequin, Laurent F.A., Hickinson, D. Mark, Hollingsworth, Ian M., Kettle, Jason G., Klinowska, Teresa, Ogilvie, Donald J., Pearson, Stuart E., Scott, James S., Suleman, Abid, Whittaker, Robin, Williams, Emma J., Wood, Robin, Wright, Lindsay
Published in Bioorganic & medicinal chemistry (15.11.2007)
Published in Bioorganic & medicinal chemistry (15.11.2007)
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Discovery of phenoxyindazoles and phenylthioindazoles as RORγ inverse agonists
Ouvry, Gilles, Bouix-Peter, Claire, Ciesielski, Fabrice, Chantalat, Laurent, Christin, Olivier, Comino, Catherine, Duvert, Denis, Feret, Christophe, Harris, Craig S., Lamy, Laurent, Luzy, Anne-Pascale, Musicki, Branislav, Orfila, Danielle, Pascau, Jonathan, Parnet, Véronique, Perrin, Agnès, Pierre, Romain, Polge, Gaëlle, Raffin, Catherine, Rival, Yves, Taquet, Nathalie, Thoreau, Etienne, Hennequin, Laurent F.
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
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Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket
Ballard, Peter, Bradbury, Robert H., Harris, Craig S., Hennequin, Laurent F.A., Hickinson, Mark, Johnson, Paul D., Kettle, Jason G., Klinowska, Teresa, Leach, Andrew G., Morgentin, Remy, Pass, Martin, Ogilvie, Donald J., Olivier, Annie, Warin, Nicolas, Williams, Emma J.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma
Fournier, Jean-François, Bhurruth-Alcor, Yushma, Musicki, Branislav, Aubert, Jérome, Aurelly, Michèle, Bouix-Peter, Claire, Bouquet, Karinne, Chantalat, Laurent, Delorme, Marion, Drean, Bénédicte, Duvert, Gwenaelle, Fleury-Bregeot, Nicolas, Gauthier, Blanche, Grisendi, Karine, Harris, Craig S., Hennequin, Laurent F., Isabet, Tatiana, Joly, Florence, Lafitte, Guillaume, Millois, Corinne, Morgentin, Rémy, Pascau, Jonathan, Piwnica, David, Rival, Yves, Soulet, Catherine, Thoreau, Étienne, Tomas, Loïc
Published in Bioorganic & medicinal chemistry letters (15.09.2018)
Published in Bioorganic & medicinal chemistry letters (15.09.2018)
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Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis
Boiteau, Jean-Guy, Ouvry, Gilles, Arlabosse, Jean-Marie, Astri, Stéphanie, Beillard, Audrey, Bhurruth-Alcor, Yushma, Bonnary, Laetitia, Bouix-Peter, Claire, Bouquet, Karine, Bourotte, Marilyne, Cardinaud, Isabelle, Comino, Catherine, Deprez, Benoît, Duvert, Denis, Féret, Angélique, Hacini-Rachinel, Feriel, Harris, Craig S., Luzy, Anne-Pascale, Mathieu, Arnaud, Millois, Corinne, Orsini, Nicolas, Pascau, Jonathan, Pinto, Artur, Piwnica, David, Polge, Gaëlle, Reitz, Arnaud, Reversé, Kevin, Rodeville, Nicolas, Rossio, Patricia, Spiesse, Delphine, Tabet, Samuel, Taquet, Nathalie, Tomas, Loïc, Vial, Emmanuel, Hennequin, Laurent F.
Published in Bioorganic & medicinal chemistry (15.02.2018)
Published in Bioorganic & medicinal chemistry (15.02.2018)
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Sulfoximines as potent RORγ inverse agonists
Ouvry, Gilles, Bihl, Franck, Bouix-Peter, Claire, Christin, Olivier, Defoin-Platel, Claire, Deret, Sophie, Feret, Christophe, Froude, David, Hacini-Rachinel, Feriel, Harris, Craig S., Hervouet, Catherine, Lafitte, Guillaume, Luzy, Anne-Pascale, Musicki, Branislav, Orfila, Danielle, Parnet, Veronique, Pascau, Coralie, Pascau, Jonathan, Pierre, Romain, Raffin, Catherine, Rossio, Patricia, Spiesse, Delphine, Taquet, Nathalie, Thoreau, Etienne, Vatinel, Rodolphe, Vial, Emmanuel, Hennequin, Laurent F.
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
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ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
WEDGE, Stephen R, OGILVIE, Donald J, GRAHAM, George A, HUGHES, Gareth D, THOMAS, Andrew P, STOKES, Elaine S. E, CURRY, Brenda, RICHMOND, Graham H. P, WADSWORTH, Peter F, BIGLEY, Alison L, HENNEQUIN, Laurent F, DUKES, Michael, KENDREW, Jane, CHESTER, Rosemary, JACKSON, Janet A, BOFFEY, Sarah J, VALENTINE, Paula J, CURWEN, Jon O, MUSGROVE, Helen L
Published in Cancer research (Chicago, Ill.) (15.08.2002)
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Published in Cancer research (Chicago, Ill.) (15.08.2002)
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Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: Synthesis and structure–activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors
Hennequin, Laurent F.A., Ballard, Peter, Boyle, F. Tom, Delouvrié, Bénédicte, Ellston, Rebecca P.A., Halsall, Chris T., Harris, Craig S., Hudson, Kevin, Kendrew, Jane, Pease, J. Elizabeth, Ross, Helen S., Smith, Peter, Vincent, Jennifer L.
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
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Identification of novel TACE inhibitors compatible with topical application
Ouvry, Gilles, Berton, Yaël, Bhurruth-Alcor, Yushma, Bonnary, Laetitia, Bouix-Peter, Claire, Bouquet, Karine, Bourotte, Marilyne, Chambon, Sandrine, Comino, Catherine, Deprez, Benoît, Duvert, Denis, Duvert, Gwenaëlle, Hacini-Rachinel, Feriel, Harris, Craig S., Luzy, Anne-Pascale, Mathieu, Arnaud, Millois, Corinne, Pascau, Jonathan, Pinto, Artur, Polge, Gaëlle, Reitz, Arnaud, Reversé, Kevin, Rosignoli, Carine, Taquet, Nathalie, Hennequin, Laurent F.
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
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Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors
Ouvry, Gilles, Clary, Laurence, Tomas, Loïc, Aurelly, Michèle, Bonnary, Laetitia, Borde, Emilie, Bouix-Peter, Claire, Chantalat, Laurent, Defoin-Platel, Claire, Deret, Sophie, Forissier, Mathieu, Harris, Craig S, Isabet, Tatiana, Lamy, Laurent, Luzy, Anne-Pascale, Pascau, Jonathan, Soulet, Catherine, Taddei, Alessandro, Taquet, Nathalie, Thoreau, Etienne, Varvier, Emeric, Vial, Emmanuel, Hennequin, Laurent F
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
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Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src
Plé, Patrick A, Green, Tim P, Hennequin, Laurent F, Curwen, Jon, Fennell, Michael, Allen, Jack, Lambert-van der Brempt, Christine, Costello, Gerard
Published in Journal of medicinal chemistry (12.02.2004)
Published in Journal of medicinal chemistry (12.02.2004)
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Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors
Hennequin, Laurent F, Stokes, Elaine S. E, Thomas, Andrew P, Johnstone, Craig, Plé, Patrick A, Ogilvie, Donald J, Dukes, Michael, Wedge, Stephen R, Kendrew, Jane, Curwen, Jon O
Published in Journal of medicinal chemistry (14.03.2002)
Published in Journal of medicinal chemistry (14.03.2002)
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Three-point variation of a gefinitib quinazoline core
Harris, Craig S., Hennequin, Laurent F., Willerval, Olivier
Published in Tetrahedron letters (08.04.2009)
Published in Tetrahedron letters (08.04.2009)
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