Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion
Henley, 3rd, Charles, Yang, Yuhua, Davis, James, Lu, Jenny Ying Lin, Morony, Sean, Fan, Wei, Florio, Monica, Sun, Banghua, Shatzen, Edward, Pretorius, James K, Richards, William G, St Jean, Jr, David J, Fotsch, Christopher, Reagan, Jeff D
Published in The Journal of pharmacology and experimental therapeutics (01.06.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2011)
Get full text
Journal Article
Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism
Wehn, Paul M., Harrington, Paul E., Carlson, Timothy J., Davis, James, Deprez, Pierre, Fotsch, Christopher H., Grillo, Mark P., Lu, Jenny Ying-Lin, Morony, Sean, Pattabiraman, Kanaka, Poon, Steve F., Reagan, Jeff D., St. Jean, David J., Temal, Taoues, Wang, Minghan, Yang, Yuhua, Henley, Charles, Lively, Sarah E.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Get full text
Journal Article
Discovery and Optimization of Substituted 1-(1-Phenyl-1H-pyrazol-3-yl)methanamines as Potent and Efficacious Type II Calcimimetics
Poon, Steve F, St. Jean, David J, Harrington, Paul E, Henley, Charles, Davis, James, Morony, Sean, Lott, Fred D, Reagan, Jeff D, Lu, Jenny Ying-Lin, Yang, Yuhua, Fotsch, Christopher
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
Get full text
Journal Article
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core
Harrington, Paul E., St. Jean, David J., Clarine, Jeffrey, Coulter, Thomas S., Croghan, Michael, Davenport, Adam, Davis, James, Ghiron, Chiara, Hutchinson, Jonathan, Kelly, Michael G., Lott, Fred, Lu, Jenny Ying-Lin, Martin, David, Morony, Sean, Poon, Steve F., Portero-Larragueta, Elena, Reagan, Jeff D., Regal, Kelly A., Tasker, Andrew, Wang, Minghan, Yang, Yuhua, Yao, Guomin, Zeng, Qingping, Henley, Charles, Fotsch, Christopher
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Get full text
Journal Article