Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates
Lauschke, Volker M, Hendriks, Delilah F. G, Bell, Catherine C, Andersson, Tommy B, Ingelman-Sundberg, Magnus
Published in Chemical research in toxicology (19.12.2016)
Published in Chemical research in toxicology (19.12.2016)
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Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liver
Hendriks, Delilah, Artegiani, Benedetta, Hu, Huili, Chuva de Sousa Lopes, Susana, Clevers, Hans
Published in Nature protocols (01.01.2021)
Published in Nature protocols (01.01.2021)
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Journal Article
Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing
Artegiani, Benedetta, Hendriks, Delilah, Beumer, Joep, Kok, Rutger, Zheng, Xuan, Joore, Indi, Chuva de Sousa Lopes, Susana, van Zon, Jeroen, Tans, Sander, Clevers, Hans
Published in Nature cell biology (01.03.2020)
Published in Nature cell biology (01.03.2020)
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Journal Article
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation
Lauschke, Volker M., Vorrink, Sabine U., Moro, Sabrina M.L., Rezayee, Fatemah, Nordling, Åsa, Hendriks, Delilah F.G., Bell, Catherine C., Sison‐Young, Rowena, Park, B. Kevin, Goldring, Christopher E., Ellis, Ewa, Johansson, Inger, Mkrtchian, Souren, Andersson, Tommy B., Ingelman‐Sundberg, Magnus
Published in Hepatology (Baltimore, Md.) (01.11.2016)
Published in Hepatology (Baltimore, Md.) (01.11.2016)
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Journal Article
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Bell, Catherine C, Hendriks, Delilah F G, Moro, Sabrina M L, Ellis, Ewa, Walsh, Joanne, Renblom, Anna, Fredriksson Puigvert, Lisa, Dankers, Anita C A, Jacobs, Frank, Snoeys, Jan, Sison-Young, Rowena L, Jenkins, Rosalind E, Nordling, Åsa, Mkrtchian, Souren, Park, B Kevin, Kitteringham, Neil R, Goldring, Christopher E P, Lauschke, Volker M, Ingelman-Sundberg, Magnus
Published in Scientific reports (04.05.2016)
Published in Scientific reports (04.05.2016)
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Journal Article
Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells
Baze, Audrey, Parmentier, Céline, Hendriks, Delilah F.G., Hurrell, Tracey, Heyd, Bruno, Bachellier, Philippe, Schuster, Catherine, Ingelman-Sundberg, Magnus, Richert, Lysiane
Published in Tissue engineering. Part C, Methods (01.09.2018)
Published in Tissue engineering. Part C, Methods (01.09.2018)
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3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications
Lauschke, Volker M., Shafagh, Reza Z., Hendriks, Delilah F. G., Ingelman‐Sundberg, Magnus
Published in Biotechnology journal (01.07.2019)
Published in Biotechnology journal (01.07.2019)
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Journal Article
Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes
Hendriks, Delilah F.G., Vorrink, Sabine U., Smutny, Tomas, Sim, Sarah C., Nordling, Åsa, Ullah, Shahid, Kumondai, Masaki, Jones, Barry C., Johansson, Inger, Andersson, Tommy B., Lauschke, Volker M., Ingelman‐Sundberg, Magnus
Published in Clinical pharmacology and therapeutics (01.10.2020)
Published in Clinical pharmacology and therapeutics (01.10.2020)
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Journal Article
Expression and Function of mARC: Roles in Lipogenesis and Metabolic Activation of Ximelagatran
Neve, Etienne P A, Köfeler, Harald, Hendriks, Delilah F G, Nordling, Åsa, Gogvadze, Vladimir, Mkrtchian, Souren, Näslund, Erik, Ingelman-Sundberg, Magnus
Published in PloS one (17.09.2015)
Published in PloS one (17.09.2015)
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Journal Article
Mechanisms of Chronic Fialuridine Hepatotoxicity as Revealed in Primary Human Hepatocyte Spheroids
Hendriks, Delilah F G, Hurrell, Tracey, Riede, Julia, van der Horst, Muriëlle, Tuovinen, Sarianna, Ingelman-Sundberg, Magnus
Published in Toxicological sciences (01.10.2019)
Published in Toxicological sciences (01.10.2019)
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Journal Article
Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity
Pagliaro, Anna, Finger, Roxy, Zoutendijk, Iris, Bunschuh, Saskia, Clevers, Hans, Hendriks, Delilah, Artegiani, Benedetta
Published in Nature communications (28.11.2023)
Published in Nature communications (28.11.2023)
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Journal Article
Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent
Parmentier, Céline, Hendriks, Delilah F.G., Heyd, Bruno, Bachellier, Philippe, Ingelman-Sundberg, Magnus, Richert, Lysiane
Published in Toxicology letters (01.10.2018)
Published in Toxicology letters (01.10.2018)
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Journal Article
High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells
Beumer, Joep, Puschhof, Jens, Bauzá-Martinez, Julia, Martínez-Silgado, Adriana, Elmentaite, Rasa, James, Kylie R., Ross, Alexander, Hendriks, Delilah, Artegiani, Benedetta, Busslinger, Georg A., Ponsioen, Bas, Andersson-Rolf, Amanda, Saftien, Aurelia, Boot, Charelle, Kretzschmar, Kai, Geurts, Maarten H., Bar-Ephraim, Yotam E., Pleguezuelos-Manzano, Cayetano, Post, Yorick, Begthel, Harry, van der Linden, Franka, Lopez-Iglesias, Carmen, van de Wetering, Willine J., van der Linden, Reinier, Peters, Peter J., Heck, Albert J.R., Goedhart, Joachim, Snippert, Hugo, Zilbauer, Matthias, Teichmann, Sarah A., Wu, Wei, Clevers, Hans
Published in Cell (11.06.2020)
Published in Cell (11.06.2020)
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New Approach Methodologies for Human-Relevant Biokinetics Predictions: Meeting the Paradigm Shift in Toxicology Towards an Animal-Free Chemical Risk Assessment
Punt, Ans, Bouwmeester, Hans, Blaauboer, Bas J, Coecke, Sandra, Hakkert, Betty, Hendriks, Delilah F.G, Jennings, Paul, Kramer, Nynke I, Neuhoff, Sibylle, Masereeuw, Rosalinde, Paini, Alicia, Peijnenburg, Ad A.C.M, Rooseboom, Ma, Shuler, Michael L, Sorrell, Ian, Spee, Bart, Strikwold, Marije, van der Meer, Andries D, van der Zande, Meike, Vinken, Mathieu, Yang, Huan, Bos, Peter M.J, Heringa, Minne B
Published in ALTEX, alternatives to animal experimentation (01.01.2020)
Published in ALTEX, alternatives to animal experimentation (01.01.2020)
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Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss
Rüland, Laura, Andreatta, Francesco, Massalini, Simone, Chuva de Sousa Lopes, Susana, Clevers, Hans, Hendriks, Delilah, Artegiani, Benedetta
Published in Nature communications (03.05.2023)
Published in Nature communications (03.05.2023)
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Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid
Vredenburg, Galvin, Elias, Naura S, Venkataraman, Harini, Hendriks, Delilah F. G, Vermeulen, Nico P. E, Commandeur, Jan N. M, Vos, J. Chris
Published in Chemical research in toxicology (21.04.2014)
Published in Chemical research in toxicology (21.04.2014)
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Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth
Hendriks, Delilah, Artegiani, Benedetta, Margaritis, Thanasis, Zoutendijk, Iris, Chuva de Sousa Lopes, Susana, Clevers, Hans
Published in Nature communications (13.05.2024)
Published in Nature communications (13.05.2024)
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Journal Article
Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis
Hurrell, Tracey, Kastrinou-Lampou, Vlasia, Fardellas, Achilleas, Hendriks, Delilah F G, Nordling, Åsa, Johansson, Inger, Baze, Audrey, Parmentier, Céline, Richert, Lysiane, Ingelman-Sundberg, Magnus
Published in Cells (Basel, Switzerland) (14.04.2020)
Published in Cells (Basel, Switzerland) (14.04.2020)
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One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
Geurts, Maarten H., Gandhi, Shashank, Boretto, Matteo G., Akkerman, Ninouk, Derks, Lucca L. M., van Son, Gijs, Celotti, Martina, Harshuk-Shabso, Sarina, Peci, Flavia, Begthel, Harry, Hendriks, Delilah, Schürmann, Paul, Andersson-Rolf, Amanda, Chuva de Sousa Lopes, Susana M., van Es, Johan H., van Boxtel, Ruben, Clevers, Hans
Published in Nature communications (17.08.2023)
Published in Nature communications (17.08.2023)
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