A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia
Legge, Sophie E., Pardiñas, Antonio F., Helthuis, Marinka, Jansen, John A., Jollie, Karel, Knapper, Steven, MacCabe, James H., Rujescu, Dan, Collier, David A., O’Donovan, Michael C., Owen, Michael J, Walters, James T. R.
Published in Molecular psychiatry (01.03.2019)
Published in Molecular psychiatry (01.03.2019)
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Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism
Pardiñas, Antonio F, Nalmpanti, Mariana, Pocklington, Andrew J, Legge, Sophie E, Medway, Christopher, King, Adrian, Jansen, John, Helthuis, Marinka, Zammit, Stanley, MacCabe, James, Owen, Michael J, O’Donovan, Michael C, Walters, James T.R
Published in The American journal of psychiatry (01.06.2019)
Published in The American journal of psychiatry (01.06.2019)
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Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia
Willcocks, Isabella R, Legge, Sophie E, Nalmpanti, Mariana, Mazzeo, Lucy, King, Adrian, Jansen, John, Helthuis, Marinka, Owen, Michael J, O'Donovan, Michael C, Walters, James T R, Pardiñas, Antonio F
Published in Frontiers in pharmacology (16.04.2021)
Published in Frontiers in pharmacology (16.04.2021)
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Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count
Lock, Siobhan K., Legge, Sophie E., Kappel, Djenifer B., Willcocks, Isabella R., Helthuis, Marinka, Jansen, John, Walters, James T. R., Owen, Michael J., O’Donovan, Michael C., Pardiñas, Antonio F.
Published in NPJ schizophrenia (18.10.2023)
Published in NPJ schizophrenia (18.10.2023)
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There Is Life After the UK Clozapine Central Non-Rechallenge Database
Oloyede, Ebenezer, Casetta, Cecilia, Dzahini, Olubanke, Segev, Aviv, Gaughran, Fiona, Shergill, Sukhi, Mijovic, Alek, Helthuis, Marinka, Whiskey, Eromona, MacCabe, James Hunter, Taylor, David
Published in Schizophrenia bulletin (08.07.2021)
Published in Schizophrenia bulletin (08.07.2021)
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86. RARE VARIANTS IN PHARMACOGENES IMPACT CLOZAPINE METABOLISM IN INDIVIDUALS WITH TREATMENT-RESISTANT SCHIZOPHRENIA
Kappel, Djenifer B., Creeth, Hugo D.J., Rees, Elliott, King, Adrian, Helthuis, Marinka, Jansen, John, Walters, James T.R., Pardiñas, Antonio F.
Published in European neuropsychopharmacology (01.10.2022)
Published in European neuropsychopharmacology (01.10.2022)
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Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores
Kappel, Djenifer B., Legge, Sophie E., Hubbard, Leon, Willcocks, Isabella R., O’Connell, Kevin S., Smith, Robert L., Molden, Espen, Andreassen, Ole A., King, Adrian, Jansen, John, Helthuis, Marinka, Owen, Michael J., O’Donovan, Michael C., Walters, James T.R., Pardiñas, Antonio F.
Published in Biological psychiatry (1969) (15.01.2023)
Published in Biological psychiatry (1969) (15.01.2023)
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Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia
Kappel, Djenifer B., Rees, Elliott, Fenner, Eilidh, King, Adrian, Jansen, John, Helthuis, Marinka, Owen, Michael J., O'Donovan, Michael C., Walters, James T.R., Pardiñas, Antonio F.
Published in European neuropsychopharmacology (01.03.2024)
Published in European neuropsychopharmacology (01.03.2024)
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Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical monitoring data
Pardiñas, Antonio F, Kappel, Djenifer B, Roberts, Milly, Tipple, Francesca, Shitomi-Jones, Lisa M, King, Adrian, Jansen, John, Helthuis, Marinka, Owen, Michael J, O'Donovan, Michael C, Walters, James T R
Published in The Lancet. Psychiatry (01.03.2023)
Published in The Lancet. Psychiatry (01.03.2023)
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PHARMACOGENOMIC ARCHITECTURE OF CLOZAPINE PLASMA CONCENTRATIONS
Pardiñas, Antonio, Nalmpanti, Mariana, Pocklington, Andrew, Sophie, Sophie, Medway, Christopher, King, Adrian, Jansen, John, Helthuis, Marinka, Owen, Michael, O'Donovan, Michael, Walters, James
Published in European neuropsychopharmacology (2019)
Published in European neuropsychopharmacology (2019)
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THE IMPACT OF THE DUFFY-NULL GENOTYPE IN CLOZAPINE-ASSOCIATED NEUTROPENIA: A GENOME-WIDE ASSOCIATION STUDY IN INDIVIDUALS OF AFRICAN ANCESTRY
Legge, Sophie, F. Pardiñas, Antonio, Helthuis, Marinka, A. Jansen, John, Jollie, Karel, Knapper, Steven, H. MacCabe, James, Rujescu, Dan, A. Collier, David, C. O'Donovan, Michael, J. Owen, Michael, T. R. Walters, James
Published in European neuropsychopharmacology (2019)
Published in European neuropsychopharmacology (2019)
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