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Kuntz, Elodie M, Baquero, Pablo, Michie, Alison M, Dunn, Karen, Tardito, Saverio, Holyoake, Tessa L, Helgason, G Vignir, Gottlieb, Eyal
Published in Nature medicine (01.10.2017)
Published in Nature medicine (01.10.2017)
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Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival
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Published in Blood (09.02.2012)
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Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
Rattigan, Kevin M, Brabcova, Zuzana, Sarnello, Daniele, Zarou, Martha M, Roy, Kiron, Kwan, Ryan, de Beauchamp, Lucie, Dawson, Amy, Ianniciello, Angela, Khalaf, Ahmed, Kalkman, Eric R, Scott, Mary T, Dunn, Karen, Sumpton, David, Michie, Alison M, Copland, Mhairi, Tardito, Saverio, Gottlieb, Eyal, Vignir Helgason, G
Published in Nature communications (17.08.2023)
Published in Nature communications (17.08.2023)
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ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy
Ianniciello, Angela, Zarou, Martha M, Rattigan, Kevin M, Scott, Mary, Dawson, Amy, Dunn, Karen, Brabcova, Zuzana, Kalkman, Eric R, Nixon, Colin, Michie, Alison M, Copland, Mhairi, Vetrie, David, Ambler, Martin, Saxty, Barbara, Helgason, G Vignir
Published in Science translational medicine (29.09.2021)
Published in Science translational medicine (29.09.2021)
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Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
Bellodi, Cristian, Lidonnici, Maria Rosa, Hamilton, Ashley, Helgason, G Vignir, Soliera, Angela Rachele, Ronchetti, Mattia, Galavotti, Sara, Young, Kenneth W, Selmi, Tommaso, Yacobi, Rinat, Van Etten, Richard A, Donato, Nick, Hunter, Ann, Dinsdale, David, Tirrò, Elena, Vigneri, Paolo, Nicotera, Pierluigi, Dyer, Martin J, Holyoake, Tessa, Salomoni, Paolo, Calabretta, Bruno
Published in The Journal of clinical investigation (01.05.2009)
Published in The Journal of clinical investigation (01.05.2009)
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Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing
Zarou, Martha M, Rattigan, Kevin M, Sarnello, Daniele, Shokry, Engy, Dawson, Amy, Ianniciello, Angela, Dunn, Karen, Copland, Mhairi, Sumpton, David, Vazquez, Alexei, Helgason, G Vignir
Published in Nature communications (02.03.2024)
Published in Nature communications (02.03.2024)
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hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival
Pellicano, Francesca, Park, Laura, Hopcroft, Lisa E.M., Shah, Mansi M., Jackson, Lorna, Scott, Mary T., Clarke, Cassie J., Sinclair, Amy, Abraham, Sheela A., Hair, Alan, Helgason, G. Vignir, Aspinall-O'Dea, Mark, Bhatia, Ravi, Leone, Gustavo, Kranc, Kamil R., Whetton, Anthony D., Holyoake, Tessa L.
Published in Blood (05.04.2018)
Published in Blood (05.04.2018)
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The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors
Pellicano, Francesca, Scott, Mary T., Helgason, G. Vignir, Hopcroft, Lisa E. M., Allan, Elaine K., Aspinall‐O'Dea, Mark, Copland, Mhairi, Pierce, Andrew, Huntly, Brian J. P., Whetton, Anthony D., Holyoake, Tessa L.
Published in Stem cells (Dayton, Ohio) (01.09.2014)
Published in Stem cells (Dayton, Ohio) (01.09.2014)
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Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche
Dawson, Amy, Zarou, Martha M, Prasad, Bodhayan, Bittencourt-Silvestre, Joana, Zerbst, Désirée, Himonas, Ekaterini, Hsieh, Ya-Ching, van Loon, Isabel, Blanco, Giovanny Rodriguez, Ianniciello, Angela, Kerekes, Zsombor, Krishnan, Vaidehi, Agarwal, Puneet, Almasoudi, Hassan, McCluskey, Laura, Hopcroft, Lisa E M, Scott, Mary T, Baquero, Pablo, Dunn, Karen, Vetrie, David, Copland, Mhairi, Bhatia, Ravi, Coffelt, Seth B, Tiong, Ong Sin, Wheadon, Helen, Zanivan, Sara, Kirschner, Kristina, Helgason, G Vignir
Published in Nature communications (05.02.2024)
Published in Nature communications (05.02.2024)
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Autophagy in blood cancers: biological role and therapeutic implications
Nencioni, Alessio, Cea, Michele, Montecucco, Fabrizio, Longo, Valter D, Patrone, Franco, Carella, Angelo M, Holyoake, Tessa L, Helgason, G Vignir
Published in Haematologica (Roma) (01.09.2013)
Published in Haematologica (Roma) (01.09.2013)
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Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor-Sensitive and -Resistant Chronic Myeloid Leukemia
Ben-Batalla, Isabel, Erdmann, Robert, Jørgensen, Heather, Mitchell, Rebecca, Ernst, Thomas, von Amsberg, Gunhild, Schafhausen, Philippe, Velthaus, Janna L, Rankin, Stephen, Clark, Richard E, Koschmieder, Steffen, Schultze, Alexander, Mitra, Subir, Vandenberghe, Peter, Brümmendorf, Tim H, Carmeliet, Peter, Hochhaus, Andreas, Pantel, Klaus, Bokemeyer, Carsten, Helgason, G Vignir, Holyoake, Tessa L, Loges, Sonja
Published in Clinical cancer research (01.05.2017)
Published in Clinical cancer research (01.05.2017)
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Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
Woodley, Keith, Dillingh, Laura S, Giotopoulos, George, Madrigal, Pedro, Rattigan, Kevin M, Philippe, Céline, Dembitz, Vilma, Magee, Aoife M S, Asby, Ryan, van de Lagemaat, Louie N, Mapperley, Christopher, James, Sophie C, Prehn, Jochen H M, Tzelepis, Konstantinos, Rouault-Pierre, Kevin, Vassiliou, George S, Kranc, Kamil R, Helgason, G Vignir, Huntly, Brian J P, Gallipoli, Paolo
Published in Nature communications (14.04.2023)
Published in Nature communications (14.04.2023)
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Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single‐cell Approaches
Yang, Fei, Nourse, Craig, Helgason, G. Vignir, Kirschner, Kristina
Published in HemaSphere (01.06.2023)
Published in HemaSphere (01.06.2023)
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BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia
Smith, Lindsay D, Minton, Annabel R, Blunt, Matthew D, Karydis, Laura I, Dutton, David A, Rogers-Broadway, Karly-Rai, Dobson, Rachel, Liu, Rena, Norster, Faith, Hogg, Elizabeth, Ashton-Key, Margaret, Strefford, Jonathan C, Jia, Li, Efremov, Dimitar G, Helgason, G Vignir, Johnson, Peter W M, Stevenson, Freda K, Forconi, Francesco, Cragg, Mark S, Tumbarello, David A, Packham, Graham, Steele, Andrew J
Published in Leukemia (01.02.2020)
Published in Leukemia (01.02.2020)
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BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia
Parry, Narissa, Busch, Caroline, Aßmann, Victoria, Cassels, Jennifer, Hair, Alan, Helgason, G Vignir, Wheadon, Helen, Copland, Mhairi
Published in Cell death discovery (15.11.2022)
Published in Cell death discovery (15.11.2022)
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