Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M 4 Muscarinic Acetylcholine Receptor
Butler, Christopher R., Popiolek, Michael, McAllister, Laura A., LaChapelle, Erik A., Kramer, Melissa, Beck, Elizabeth M., Mente, Scot, Brodney, Michael A., Brown, Matthew, Gilbert, Adam, Helal, Chris, Ogilvie, Kevin, Starr, Jeremy, Uccello, Daniel, Grimwood, Sarah, Edgerton, Jeremy, Garst-Orozco, Jonathan, Kozak, Rouba, Lotarski, Susan, Rossi, Amie, Smith, Deborah, O’Connor, Rebecca, Lazzaro, John, Steppan, Claire, Steyn, Stefanus J.
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
Get full text
Journal Article
Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor
Butler, Christopher R., Popiolek, Michael, McAllister, Laura A., LaChapelle, Erik A., Kramer, Melissa, Beck, Elizabeth M., Mente, Scot, Brodney, Michael A., Brown, Matthew, Gilbert, Adam, Helal, Chris, Ogilvie, Kevin, Starr, Jeremy, Uccello, Daniel, Grimwood, Sarah, Edgerton, Jeremy, Garst-Orozco, Jonathan, Kozak, Rouba, Lotarski, Susan, Rossi, Amie, Smith, Deborah, O’Connor, Rebecca, Lazzaro, John, Steppan, Claire, Steyn, Stefanus J.
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
Get full text
Journal Article
P3‐313: Using single‐point pharmacokinetic/pharmacodynamic (PK/PD) analyses to support early discovery of inhibitors of β‐site APP cleaving enzyme 1 (BACE1)
Lu, Yasong, Liu, Jianhua, Nelson, Frederick, Ambroise, Claude, Fisher, Katherine, Hajos-Korcsok, Eva, Noell, Stephen, Nolan, Charles E., Oborski, Christine E., Lanyon, Lorraine F., Christoffersen, Curt, Hannah, Divine, Efremov, Ivan, Helal, Chris, Brodney, Michael A., O'Neill, Brian T.
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
Get full text
Journal Article
Using single-point pharmacokinetic/pharmacodynamic (PK/PD) analyses to support early discovery of inhibitors of β-site APP cleaving enzyme 1 (BACE1)
Lu, Yasong, Liu, Jianhua, Nelson, Frederick, Ambroise, Claude, Fisher, Katherine, Hajos-Korcsok, Eva, Noell, Stephen, Nolan, Charles E, Oborski, Christine E, Lanyon, Lorraine F, Christoffersen, Curt, Hannah, Divine, Efremov, Ivan, Helal, Chris, Brodney, Michael A, O'Neill, Brian T
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
Get full text
Journal Article
Heteroaromatic Compounds and their Use as Dopamine D1 Ligands
HARRIS ANTHONY RICHARD, DOUNAY AMY BETH, DAVOREN JENNIFER ELIZABETH, NASON DEANE MILFORD, COE JOTHAM WADSWORTH, O'NEIL STEVEN VICTOR, GRAY DAVID LAWRENCE FIRMAN, GUILMETTE EDWARD RAYMOND, EFREMOV IVAN VIKTOROVICH, MENTE SCOT RICHARD, XU WENJIAN, ALLEN JOHN ARTHUR, HELAL CHRIS JOHN, SUBRAMANYAM CHAKRAPANI, HENDERSON JACLYN LOUISE
Year of Publication 15.06.2017
Get full text
Year of Publication 15.06.2017
Patent
Heteroaromatic compounds and their use as dopamine D1 ligands
Mente Scot Richard, Coe Jotham Wadsworth, Gray David Lawrence Firman, Guilmette Edward Raymond, Nason Deane Milford, Dounay Amy Beth, Henderson Jaclyn Louise, O'Neil Steven Victor, Davoren Jennifer Elizabeth, Efremov Ivan Viktorovich, Harris Anthony Richard, Xu Wenjian, Helal Chris John, Allen John Arthur, Subramanyam Chakrapani
Year of Publication 11.04.2017
Get full text
Year of Publication 11.04.2017
Patent
Heteroaromatic Compounds and their Use as Dopamine D1 Ligands
HARRIS ANTHONY RICHARD, DOUNAY AMY BETH, DAVOREN JENNIFER ELIZABETH, NASON DEANE MILFORD, COE JOTHAM WADSWORTH, O'NEIL STEVEN VICTOR, GRAY DAVID LAWRENCE FIRMAN, GUILMETTE EDWARD RAYMOND, EFREMOV IVAN VIKTOROVICH, MENTE SCOT RICHARD, XU WENJIAN, ALLEN JOHN ARTHUR, HELAL CHRIS JOHN, SUBRAMANYAM CHAKRAPANI, HENDERSON JACLYN LOUISE
Year of Publication 03.12.2015
Get full text
Year of Publication 03.12.2015
Patent
Heteroaromatic Compounds and their Use as Dopamine D1 Ligands
HARRIS ANTHONY RICHARD, DOUNAY AMY BETH, DAVOREN JENNIFER ELIZABETH, NASON DEANE MILFORD, COE JOTHAM WADSWORTH, O'NEIL STEVEN VICTOR, GRAY DAVID LAWRENCE FIRMAN, GUILMETTE EDWARD RAYMOND, EFREMOV IVAN VIKTOROVICH, MENTE SCOT RICHARD, XU WENJIAN, ALLEN JOHN ARTHUR, HELAL CHRIS JOHN, SUBRAMANYAM CHAKRAPANI, HENDERSON JACLYN LOUISE
Year of Publication 15.10.2015
Get full text
Year of Publication 15.10.2015
Patent
Imidazole derivatives
Helal, Chris, Sanner, Mark, Cooper, Christoper, Menniti, Frank, Seymour, Patricia, Ahlijanian, Michael, Villalobos, Anabella, Lau, Lit-Fui
Year of Publication 30.09.2004
Get full text
Year of Publication 30.09.2004
Patent
Imidazole derivatives
Sanner, Mark A, Helal, Chris J, Cooper, Christoper B, Menniti, Frank S, Seymour, Patricia A, Ahlijanian, Michael K, Villalobos, Anabella, Lau, Lit-Fui
Year of Publication 18.07.2006
Get full text
Year of Publication 18.07.2006
Patent
Imidazole derivatives
HELAL CHRIS J, SEYMOUR PATRICIA A, VILLALOBOS ANABELLA, LAU LIT-FUI, AHLIJANIAN MICHAEL K, MENNITI FRANK S, SANNER MARK A, COOPER CHRISTOPER B
Year of Publication 18.07.2006
Get full text
Year of Publication 18.07.2006
Patent
Imidazole derivatives
HELAL CHRIS J, COOPER CHRISTOPHER B, SEYMOUR PATRICIA A, VILLALOBOS ANABELLA, LAU LIT-FUI, AHLIJANIAN MICHAEL K, MENNITI FRANK S, SANNER MARK A
Year of Publication 06.07.2006
Get full text
Year of Publication 06.07.2006
Patent