Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage
Pourebrahim, Rasoul, Heinz Montoya, Rafael, Alaniz, Zoe, Ostermann, Lauren, Lin, Patrick P, Liu, Bin, Ayoub, Edward, Burks, Jared K, Andreeff, Michael
Published in Cell death & disease (23.06.2023)
Published in Cell death & disease (23.06.2023)
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Journal Article
DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia
Haines, Eric, Nishida, Yuki, Carr, Michael I, Montoya, Rafael Heinz, Ostermann, Lauren B, Zhang, Weiguo, Zenke, Frank T, Blaukat, Andree, Andreeff, Michael, Vassilev, Lyubomir T
Published in Scientific reports (09.06.2021)
Published in Scientific reports (09.06.2021)
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Journal Article
Traceable Mouse Models for Tracking p53-Mutant Subclones in Acute Myeloid Leukemia
Pourebrahim, Rasoul, Heinz Montoya, Rafael, Ostermann, Lauren B, Andreeff, Michael
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Mdm2 Maintains Cholesterol Biosynthesis in Hematopoietic Stem/Progenitor Cells Independent of p53
Pourebrahim, Rasoul, Heinz Montoya, Rafael, Ayoub, Edward, Khoury, Joseph D., Andreeff, Michael
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Osterix Marks a Distinct Population of Circulatory Bone Marrow Mesenchymal Stem Cells That Is Increased upon Oncogenic Stress
Montoya, Rafael Heinz, Pourebrahim, Rasoul, Alaniz, Zoe, Ostermann, Lauren B, Burks, Jared K., Andreeff, Michael
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Mdm2 Loss of Heterozygosity Cooperates with Mutant p53 in Acute Myeloid Leukemia
Pourebrahim, Rasoul, Montoya, Rafael Heinz, Alaniz, Zoe, Ostermann, Lauren B, Luong, Hung Alex, Khoury, Joseph D., Andreeff, Michael
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Mdm2 Haplo-Insufficiency in Hematopoietic and Mesenchymal Progenitor Cells Results in Cell Death
Pourebrahim, Rasoul, Montoya, Rafael Heinz, Alaniz, Zoe, Ostermann, Lauren B, Ayoub, Edward, Lin, Patrick P, Burks, Jared K., Andreeff, Michael
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Targeting Polo-like Kinase 4 Triggers Polyploidy and Apoptotic Cell Death in TP53-Mutant Acute Myeloid Leukemia
Ayoub, Edward, Heinz Montoya, Rafael, Mohanty, Vakul, Walter, Wencke, Patsilevas, Tallie, Issa, Ghayas C., Borthakur, Gautam, Chen, Ken, Konopleva, Marina, Navin, Nicholas, Haferlach, Torsten, Andreeff, Michael
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Polyploidy Is Necessary for Apoptotic Cell Death in TP53-Mut AML in Response to Polo-like-Kinase 4 (PLK4) Inhibition and Results in Caspase 3 Cleavage
Ayoub, Edward, Marupudi, Akhil, Nishida, Yuki, Heinz Montoya, Rafael, Mohanty, Vakul, Walter, Wencke, Bray, Mark R, Patsilevas, Tallie, Boettcher, Steffen, Issa, Ghayas C., Chen, Ken, Haferlach, Torsten, Borthakur, Gautam, Andreeff, Michael
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Mdm2 Loss of Heterozygosity Cooperates with Mutant p53 in the Development of Acute Myeloid Leukemia
Pourebrahim, Rasoul, Heinz Montoya, Rafael, Ayoub, Edward, Akiyama, Hiroki, Baran, Natalia, Lesluyes, Tom, Ostermann, Lauren B, Liu, Bin, Ishizawa, Jo, Khoury, Joseph D., Konopleva, Marina, Van Loo, Peter, Andreeff, Michael
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Dual Inhibition of MDM2 and XPO1 Synergizes to Induce Apoptosis in Acute Myeloid Leukemia Progenitor Cells with Wild-Type TP53 through Nuclear Accumulation of p53 and Suppression of c-Myc
Nishida, Yuki, Ishizawa, Jo, Ruvolo, Vivian, Kojima, Kensuke, Montoya, Rafael Heinz, Daver, Naval G., Lesegretain, Arnaud, Shacham, Sharon, Andreeff, Michael
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Exportin-1 (XPO1) Inhibition Sequesters p53 from MDM2 and MDM4 and Is Highly Synergistic with MDM2 Inhibition in Inducing Apoptosis in Wild-Type p53 Acute Myeloid Leukemias
Nishida, Yuki, Ishizawa, Jo, Ayoub, Edward, Montoya, Rafael Heinz, Ruvolo, Vivian, Kojima, Kensuke, Daver, Naval, Lesegretain, Arnaud, Shacham, Sharon, Andreeff, Michael
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Clonal Expansion of Mutant p53 Clones By MDM2 Inhibition in Acute Myeloid Leukemias
Nishida, Yuki, Montoya, Rafael Heinz, Morita, Kiyomi, Tanaka, Tomoyuki, Wang, Feng, Takahashi, Koichi, Ishizawa, Jo, Kumar, Prasanna, Patel, Parul, Dos Santos, Cedric E., DiNardo, Courtney D., Andreeff, Michael
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Enhanced p53 Activation By Dual Inhibition of MDM2 and XPO1 Disrupts MYC Transcriptional Program and Restores Sensitivity to BCL-2 Inhibition in Ven/HMA Resistant AML
Nishida, Yuki, Ishizawa, Jo, Ayoub, Edward, Patsilevas, Tallie, Ostermann, Lauren, Montoya, Rafael Heinz, Muftuoglu, Muharrem, Ruvolo, Vivian, Mak, Po Yee, Tao, Wenjing, Carter, Bing Z, Kojima, Kensuke, Daver, Naval, Lesegretain, Arnaud, Seki, Takahiko, Shacham, Sharon, Konopleva, Marina, Andreeff, Michael
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
p53 Mediated Bone Marrow Mesenchymal Stem Cell Expansion Supports Acute Myeloid Leukemia Development
Pourebrahimabadi, Rasoul, Alaniz, Zoe, Ostermann, Lauren B, Luong, Hung Alex, Montoya, Rafael Heinz, Ruvolo, Peter P., Kornblau, Steven M., Khoury, Joseph D., Bueso-Ramos, Carlos E., Andreeff, Michael
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice
Pourebrahim, Rasoul, Montoya, Rafael Heinz, Akiyama, Hiroki, Ostermann, Lauren, Khazaei, Shayuan, Muftuoglu, Muharrem, Baran, Natalia, Zhao, Ran, Lesluyes, Tom, Liu, Bin, Khoury, Joseph D., Gagea, Mihai, Van Loo, Peter, Andreeff, Michael
Published in Cell reports. Medicine (21.05.2024)
Published in Cell reports. Medicine (21.05.2024)
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Journal Article
Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias
Nishida, Yuki, Ishizawa, Jo, Ayoub, Edward, Montoya, Rafael Heinz, Ostermann, Lauren B, Muftuoglu, Muharrem, Ruvolo, Vivian R, Patsilevas, Tallie, Scruggs, Darah A, Khazaei, Shayaun, Mak, Po Yee, Tao, Wenjing, Carter, Bing Z, Boettcher, Steffen, Ebert, Benjamin L, Daver, Naval G, Konopleva, Marina, Seki, Takahiko, Kojima, Kensuke, Andreeff, Michael
Published in Science advances (01.12.2023)
Published in Science advances (01.12.2023)
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