Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Wang, Haibo, Guo, Wenting, Mitra, Joy, Hegde, Pavana M, Vandoorne, Tijs, Eckelmann, Bradley J, Mitra, Sankar, Tomkinson, Alan E, Van Den Bosch, Ludo, Hegde, Muralidhar L
Published in Nature communications (11.09.2018)
Published in Nature communications (11.09.2018)
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Journal Article
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective
Derry, Paul J., Hegde, Muralidhar L., Jackson, George R., Kayed, Rakez, Tour, James M., Tsai, Ah-Lim, Kent, Thomas A.
Published in Progress in neurobiology (01.01.2020)
Published in Progress in neurobiology (01.01.2020)
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Journal Article
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Mitra, Joy, Guerrero, Erika N., Hegde, Pavana M., Liachko, Nicole F., Wang, Haibo, Vasquez, Velmarini, Gao, Junling, Pandey, Arvind, Taylor, J. Paul, Kraemer, Brian C., Wu, Ping, Boldogh, Istvan, Garruto, Ralph M., Mitra, Sankar, Rao, K. S., Hegde, Muralidhar L.
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2019)
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Journal Article
Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective
Kodavati, Manohar, Wang, Haibo, Hegde, Muralidhar L
Published in Cells (Basel, Switzerland) (24.04.2020)
Published in Cells (Basel, Switzerland) (24.04.2020)
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Journal Article
Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis
Guerrero, Erika N, Mitra, Joy, Wang, Haibo, Rangaswamy, Suganya, Hegde, Pavana M, Basu, Priyadarshini, Rao, K S, Hegde, Muralidhar L
Published in Human molecular genetics (01.08.2019)
Published in Human molecular genetics (01.08.2019)
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Journal Article
TDP-43/FUS in motor neuron disease: Complexity and challenges
Guerrero, Erika N, Wang, Haibo, Mitra, Joy, Hegde, Pavana M, Stowell, Sara E, Liachko, Nicole F, Kraemer, Brian C, Garruto, Ralph M, Rao, K S, Hegde, Muralidhar L
Published in Progress in neurobiology (01.10.2016)
Published in Progress in neurobiology (01.10.2016)
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Journal Article
DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders
Provasek, Vincent E, Mitra, Joy, Malojirao, Vikas H, Hegde, Muralidhar L
Published in International journal of molecular sciences (22.04.2022)
Published in International journal of molecular sciences (22.04.2022)
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Journal Article
The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis
Chatterjee, Arpita, Saha, Saikat, Chakraborty, Anirban, Silva-Fernandes, Anabela, Mandal, Santi M, Neves-Carvalho, Andreia, Liu, Yongping, Pandita, Raj K, Hegde, Muralidhar L, Hegde, Pavana M, Boldogh, Istvan, Ashizawa, Tetsuo, Koeppen, Arnulf H, Pandita, Tej K, Maciel, Patricia, Sarkar, Partha S, Hazra, Tapas K
Published in PLoS genetics (01.01.2015)
Published in PLoS genetics (01.01.2015)
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Journal Article
Activation of Ras Signaling Pathway by 8-Oxoguanine DNA Glycosylase Bound to Its Excision Product, 8-Oxoguanine
Boldogh, Istvan, Hajas, Gyorgy, Aguilera-Aguirre, Leopoldo, Hegde, Muralidhar L., Radak, Zsolt, Bacsi, Attila, Sur, Sanjiv, Hazra, Tapas K., Mitra, Sankar
Published in The Journal of biological chemistry (15.06.2012)
Published in The Journal of biological chemistry (15.06.2012)
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Journal Article
FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease
Kodavati, Manohar, Wang, Haibo, Guo, Wenting, Mitra, Joy, Hegde, Pavana M, Provasek, Vincent, Rao, Vikas H Maloji, Vedula, Indira, Zhang, Aijun, Mitra, Sankar, Tomkinson, Alan E, Hamilton, Dale J, Van Den Bosch, Ludo, Hegde, Muralidhar L
Published in Nature communications (09.03.2024)
Published in Nature communications (09.03.2024)
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Journal Article
The role of 8-oxoguanine DNA glycosylase-1 in inflammation
Ba, Xueqing, Aguilera-Aguirre, Leopoldo, Rashid, Qura Tul Ain Nmi, Bacsi, Attila, Radak, Zsolt, Sur, Sanjiv, Hosoki, Koa, Hegde, Muralidhar L, Boldogh, Istvan
Published in International Journal of Molecular Sciences (23.09.2014)
Published in International Journal of Molecular Sciences (23.09.2014)
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Journal Article
Book Review
Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity
Roychoudhury, Shrabasti, Nath, Somsubhra, Song, Heyu, Hegde, Muralidhar L., Bellot, Larry J., Mantha, Anil K., Sengupta, Shiladitya, Ray, Sutapa, Natarajan, Amarnath, Bhakat, Kishor K.
Published in Molecular and cellular biology (01.03.2017)
Published in Molecular and cellular biology (01.03.2017)
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Journal Article
TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner
Provasek, Vincent E, Kodavati, Manohar, Kim, Brandon, Mitra, Joy, Hegde, Muralidhar L
Published in Molecular brain (05.06.2024)
Published in Molecular brain (05.06.2024)
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Journal Article
Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins
Hegde, Muralidhar L, Hegde, Pavana M, Bellot, Larry J, Mandal, Santi M, Hazra, Tapas K, Li, Guo-Min, Boldogh, Istvan, Tomkinson, Alan E, Mitra, Sankar
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2013)
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Journal Article
Preferential Repair of Oxidized Base Damage in the Transcribed Genes of Mammalian Cells
Banerjee, Dibyendu, Mandal, Santi M., Das, Aditi, Hegde, Muralidhar L., Das, Soumita, Bhakat, Kishor K., Boldogh, Istvan, Sarkar, Partha S., Mitra, Sankar, Hazra, Tapas K.
Published in The Journal of biological chemistry (25.02.2011)
Published in The Journal of biological chemistry (25.02.2011)
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Journal Article
Correction: The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
Chatterjee, Arpita, Saha, Saikat, Chakraborty, Anirban, Silva-Fernandes, Anabela, Mandal, Santi M, Neves-Carvalho, Andreia, Liu, Yongping, Pandita, Raj K, Hegde, Muralidhar L, Hegde, Pavana M, Boldogh, Istvan, Ashizawa, Tetsuo, Koeppen, Arnulf H, Pandita, Tej K, Maciel, Patricia, Sarkar, Partha S, Hazra, Tapas K
Published in PLoS genetics (18.01.2024)
Published in PLoS genetics (18.01.2024)
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