Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer
Sutherlin, Daniel P, Sampath, Deepak, Berry, Megan, Castanedo, Georgette, Chang, Zhigang, Chuckowree, Irina, Dotson, Jenna, Folkes, Adrian, Friedman, Lori, Goldsmith, Richard, Heffron, Tim, Lee, Leslie, Lesnick, John, Lewis, Cristina, Mathieu, Simon, Nonomiya, Jim, Olivero, Alan, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Tian, Qingping, Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wiesmann, Christian, Wong, Susan, Zhu, Bing-Yan
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Abstract C201: A novel potent and selective inhibitor of PI3K/mTOR, GDC-0980, currently in phase I clinical trials
Friedman, Lori S., Belvin, Marcia, Berry, Leanne, Berry, Megan, Castanedo, Georgette, Edgar, Kyle, Folkes, Adrian, Guan, Jane, Heffron, Tim, Lesnick, John, Lewis, Cris, Nonomiya, Jim, Olivero, Alan, Patel, Sonal, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Sampath, Deepak, Sutherlin, Dan, Wallin, Jeff, Zhu, Bingyan
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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Abstract LB-309: Non-covalent wild-type-sparing inhibitors of EGFR T790M
Lee, Ho-June, Schaefer, Gabriele, Heffron, Tim, Malek, Shiva, Merchant, Mark, Yauch, Robert L., Pirazzoli, Valentina, Politi, Katerina, Settleman, Jeff
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Abstract 2787: Discovery of GDC-0980, a selective PI3K/mTOR inhibitor in clinical trials
Sutherlin, Daniel P., Belvin, Marcia, Bao, Linda, Berry, Leanne, Berry, Megan, Castanedo, Georgette, Edgar, Kyle, Folkes, Adrian, Friedman, Lori, Heffron, Tim, Patel, Sonal, Olivero, Alan, Lesnick, John, Lewis, Cristina, Marsters, James, Nonomiya, Jim, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Sampath, Deepak, Tsui, Vickie, Wallin, Jeff, Wei, BinQing, Weismann, Christian, Zhu, Bing-Yan
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
GOLDSMITH RICHARD A, WEI BINQING, NDUBAKU CHUDI, BLAQUIERE NICOLE, KOLESNIKOV ALEKSANDR, DUDLEY DANETTE, DO STEVEN, OLIVERO ALAN G, PRICE STEPHEN, STABEN STEVEN, FOLKES ADRIAN J, HEFFRON TIM, HEALD ROBERT
Year of Publication 20.03.2014
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Year of Publication 20.03.2014
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BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
WEI BIN QING, GOLDSMITH RICHARD A, NDUBAKU CHUDI, BLAQUIERE NICOLE, KOLESNIKOV ALEKSANDR, DUDLEY DANETTE, DO STEVEN, OLIVERO ALAN G, PRICE STEPHEN, STABEN STEVEN, FOLKES ADRIAN J, HEFFRON TIM, HEALD ROBERT
Year of Publication 20.06.2012
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Year of Publication 20.06.2012
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BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
FOLKES ADRIAN, PEGG NEIL, GOLDSMITH PAUL, BAYLISS TRACY, SIU MICHAEL, KOLESNIKOV ALEKSANDR, DO STEVEN, OLIVERO ALAN G, SUTHERLIN DANIEL P, STABEN STEVEN, ZHU BING YAN, HEFFRON TIM, GOLDSMITH RICHARD
Year of Publication 30.12.2010
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Year of Publication 30.12.2010
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Pharmaceutical compounds
Sutherlin, Daniel P, Shuttleworth, Stephen, Chuckowree, Irina, Folkes, Adrian, Heffron, Tim, Mathieu, Simon, Oxenford, Sally, Goldsmith, Richard, Castanedo, Georgette, Wan, Nan Chi, Gunzer-Toste, Janet, Olivero, Alan, Zhu, Bing-Yan
Year of Publication 17.04.2018
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Year of Publication 17.04.2018
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BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
HEALD, ROBERT, BLAQUIERE, NICOLE, DO, STEVEN, OLIVERO, ALAN G, NDUBAKU, CHUDI, DUDLEY, DANETTE, GOLDSMITH, RICHARD A, PRICE, STEPHEN, STABEN, STEVEN, FOLKES, ADRIAN J, WEI, BINQING, HEFFRON, TIM, KOLESNIKOV, ALEKSANDR
Year of Publication 03.04.2018
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Year of Publication 03.04.2018
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PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CASTANEDO, Georgette, OLIVERO, Alan, HANCOX, Tim, TSUI, Vickie, ZHU, Bing-Yan, MALESKY, Kimberly, WANG, Shumei, BAYLISS, Tracy, MATHIEU, Simon, HEFFRON, Tim, OXENFORD, Sally, GUNZNER, Janet, WEISMANN, Christian, SUTHERLIN, Daniel, P, GOLDSMITH, Richard, FOLKES, Adrian, SHUTTLEWORTH, Stephen, DOTSON, Jennafer
Year of Publication 19.07.2017
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Year of Publication 19.07.2017
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PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE
FOLKES, ADRIAN, GUNZNER, JANET, SUTHERLIN, DANIEL P, OXENFORD, SALLY, CHUCKOWREE, IRINA, OLIVERO, ALAN, GOLDSMITH, RICHARD, WAN, NAN CHI, BAYLISS, TRACY, MATHIEU, SIMON, CASTANEDO, GEORGETTE, STABEN, STEVEN, ZHU, BING-YAN, HEFFRON, TIM
Year of Publication 10.01.2017
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Year of Publication 10.01.2017
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BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
FOLKES, ADRIAN, SUTHERLIN, DANIEL P, DO, STEVEN, OLIVERO, ALAN G, GOLDSMITH, RICHARD, GOLDSMITH, PAUL, BAYLISS, TRACY, PEGG, NEIL, STABEN, STEVEN, ZHU, BING-YAN, HEFFRON, TIM, KOLESNIKOV, ALEKSANDR, SIU, MICHAEL
Year of Publication 08.11.2016
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Year of Publication 08.11.2016
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Phosphoinositide 3-kinase inhibitor compounds and methods of use
Castanedo Georgette, Staben Steven, Chuckowree Irina, Tsui Vickie, Mathieu Simon, Folkes Adrian, Gunzner Janet, Heffron Tim, Zhu Bing-Yan, Goldsmith Richard, Wang Shumei, Olivero Alan, Dotson Jennafer, Sutherlin Daniel P, Wan Nan Chi, Bayliss Tracy
Year of Publication 08.11.2016
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Year of Publication 08.11.2016
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PHARMACEUTICAL COMPOUNDS
SHUTTLEWORTH STEPHEN, ZHU BING-YAN, FOLKES ADRIAN, MATHIEU SIMON, OLIVERO ALAN, CHUCKOWREE IRINA, OXENFORD SALLY, GUNZER-TOSTE JANET, SUTHERLIN DANIEL P, WAN NAN CHI, HEFFRON TIM, GOLDSMITH RICHARD, CASTANEDO GEORGETTE
Year of Publication 02.06.2016
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Year of Publication 02.06.2016
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Pyrazolopyrimidine PI3K inhibitor compounds and methods of use
WANG SHUMEI, ZHU BING-YAN, DOTSON JENNAFER, SUTHERLIN DANIEL P, FOLKES ADRIAN, HEFFRON TIM, WAN NAN CHI, OLIVERO ALAN, CHUCKOWREE IRINA
Year of Publication 24.03.2015
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Year of Publication 24.03.2015
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Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use
ZHU BING-YAN, FOLKES ADRIAN, PEGG NEIL, GOLDSMITH PAUL, BAYLISS TRACY, SIU MICHAEL, KOLESNIKOV ALEKSANDR, DO STEVEN, OLIVERO ALAN G, SUTHERLIN DANIEL P, STABEN STEVEN, HEFFRON TIM, GOLDSMITH RICHARD
Year of Publication 12.04.2016
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Year of Publication 12.04.2016
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PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE
FOLKES, ADRIAN, GUNZNER, JANET, SUTHERLIN, DANIEL P, DOTSON, JENNAFER, CHUCKOWREE, IRINA, TSUI, VICKIE, OLIVERO, ALAN, GOLDSMITH, RICHARD, WAN, NAN CHI, BAYLISS, TRACY, MATHIEU, SIMON, CASTANEDO, GEORGETTE, STABEN, STEVEN, ZHU, BING-YAN, WANG, SHUMEI, HEFFRON, TIM
Year of Publication 09.03.2016
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Year of Publication 09.03.2016
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Compuestos inhibidores de PI3K de benzoxepina y métodos de uso
FOLKES, Adrian J, HEALD, Robert, NDUBAKU, Chudi, KOLESNIKOV, Aleksandr, DUDLEY, Danette, OLIVERO, Alan G, PRICE, Stephen, GOLDSMITH, Richard A, STABEN, Steven, HEFFRON, Tim, DO, Steven, BLAQUIERE, Nicole, WEI, BinQing
Year of Publication 08.02.2016
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Year of Publication 08.02.2016
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PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FOLKES, ADRIAN, GUNZNER, JANET, SUTHERLIN, DANIEL P, DOTSON, JENNAFER, OXENFORD, SALLY, TSUI, VICKIE, OLIVERO, ALAN, GOLDSMITH, RICHARD, HANCOX, TIM, SHUTTLEWORTH, STEPHEN, BAYLISS, TRACY, MATHIEU, SIMON, CASTANEDO, GEORGETTE, WEISMANN, CHRISTIAN, ZHU, BING-YAN, WANG, SHUMEI, HEFFRON, TIM, MALESKY, KIMBERLY
Year of Publication 29.12.2015
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Year of Publication 29.12.2015
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BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
HEALD, ROBERT, BLAQUIERE, NICOLE, DO, STEVEN, OLIVERO, ALAN G, NDUBAKU, CHUDI, DUDLEY, DANETTE, GOLDSMITH, RICHARD A, PRICE, STEPHEN, STABEN, STEVEN, FOLKES, ADRIAN J, WEI, BINQING, HEFFRON, TIM, KOLESNIKOV, ALEKSANDR
Year of Publication 02.12.2015
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Year of Publication 02.12.2015
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