Search Results - "Heffernan, Gavin D" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

In vitro efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites

In vitro efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites

by Vydyam, Pratap, Chand, Meenal, Gihaz, Shalev, Renard, Isaline, Heffernan, Gavin D., Jacobus, Laura R., Jacobus, David P., Saionz, Kurt W., Shah, Raju, Shieh, Hong-Ming, Terpinski, Jacek, Zhao, Wenyi, Cornillot, Emmanuel, Ben Mamoun, Choukri
Published in Antimicrobial agents and chemotherapy (04.09.2024)

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Journal Article

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

by Birrell, Geoffrey W., Challis, Matthew P., De Paoli, Amanda, Anderson, Dovile, Devine, Shane M., Heffernan, Gavin D., Jacobus, David P., Edstein, Michael D., Siddiqui, Ghizal, Creek, Darren J.
Published in Molecular & cellular proteomics (01.02.2020)

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Journal Article

Relevance of Higher-Order Epistasis in Drug Resistance

Relevance of Higher-Order Epistasis in Drug Resistance

by Lozovsky, Elena R, Daniels, Rachel F, Heffernan, Gavin D, Jacobus, David P, Hartl, Daniel L
Published in Molecular biology and evolution (01.01.2021)

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Journal Article

In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model

In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model

by McCallum, Fiona J, Birrell, Geoffrey W, Chavchich, Marina, Harris, Ivor, Obaldia, 3rd, Nicanor, Van Breda, Karin, Heffernan, Gavin D, Jacobus, David P, Shanks, Dennis, Edstein, Michael D
Published in Antimicrobial agents and chemotherapy (21.02.2020)

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Journal Article

Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

by Birrell, Geoffrey W, Heffernan, Gavin D, Schiehser, Guy A, Anderson, John, Ager, Arba L, Morales, Pablo, MacKenzie, Donna, van Breda, Karin, Chavchich, Marina, Jacobus, Laura R, Shanks, G Dennis, Jacobus, David P, Edstein, Michael D
Published in Antimicrobial agents and chemotherapy (01.04.2018)

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Journal Article

Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

by Chavchich, Marina, Birrell, Geoffrey W, Ager, Arba L, MacKenzie, Donna O, Heffernan, Gavin D, Schiehser, Guy A, Jacobus, Laura R, Shanks, G Dennis, Jacobus, David P, Edstein, Michael D
Published in Antimicrobial agents and chemotherapy (01.05.2016)

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Journal Article

JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium

JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium

by Birrell, Geoffrey W, Chavchich, Marina, Ager, Arba L, Shieh, Hong-Ming, Heffernan, Gavin D, Zhao, Wenyi, Krasucki, Peter E, Saionz, Kurt W, Terpinski, Jacek, Schiehser, Guy A, Jacobus, Laura R, Shanks, G Dennis, Jacobus, David P, Edstein, Michael D
Published in Antimicrobial agents and chemotherapy (01.01.2015)

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Journal Article

치환된 1-아릴-1'-헤테로아릴 화합물, 치환된 1,1'-비헤테로아릴 화합물 및 이를 사용하는 방법

치환된 1-아릴-1'-헤테로아릴 화합물, 치환된 1,1'-비헤테로아릴 화합물 및 이를 사용하는 방법

by KAKARLA RAMESH, AHUJA VIJAY, OZTURK SEYMA, KULTGEN STEVEN G, HEFFERNAN GAVIN D, DORSEY BRUCE D, QUINTERO JORGE, NGUYEN DUYAN, COLE ANDREW G, FAN YI, SOFIA MICHAEL J
Year of Publication 26.02.2024

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Patent

Structure–activity relationships of the 1-amino-3-(1 H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors

Structure–activity relationships of the 1-amino-3-(1 H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors

by Mahaney, Paige E., Kim, Callain Y., Coghlan, Richard D., Cohn, Stephen T., Heffernan, Gavin D., Huselton, Christine A., Terefenko, Eugene A., Vu, An T., Zhang, Puwen, Burroughs, Kevin D., Cosmi, Scott A., Bray, Jenifer A., Johnston, Grace H., Deecher, Darlene C., Trybulski, Eugene J.
Published in Bioorganic & medicinal chemistry letters (01.10.2009)

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Journal Article

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum

by Birrell, Geoffrey W, Challis, Matthew P, De Paoli, Amanda, Anderson, Dovile, Devine, Shane M, Heffernan, Gavin D, Jacobus, David P, Edstein, Michael D, Siddiqui, Ghizal, Creek, Darren J
Published in Molecular & cellular proteomics (01.02.2020)

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Journal Article

Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles

Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles

by HEFFERNAN, GavinD, COGHLAN, Richard D, COSMI, Scott A, JOHNSTON, Grace H, KENNEY, Thomas, KOURY, Elizabeth, WINNEKER, Richard C, DEECHER, Darlene C, TRYBULSKI, Eugene J, MANAS, Eric S, MCDEVITT, Robert E, YANFANG LI, MAHANEY, Paige E, ROBICHAUD, Albert J, HUSELTON, Christine, ALFINITO, Peter, BRAY, Jenifer A
Published in Bioorganic & medicinal chemistry (15.11.2009)

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Journal Article

Dual acting norepinephrine reuptake inhibitors and 5-HT 2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1 H-indoles

Dual acting norepinephrine reuptake inhibitors and 5-HT 2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1 H-indoles

by Heffernan, Gavin D., Coghlan, Richard D., Manas, Eric S., McDevitt, Robert E., Li, Yanfang, Mahaney, Paige E., Robichaud, Albert J., Huselton, Christine, Alfinito, Peter, Bray, Jenifer A., Cosmi, Scott A., Johnston, Grace H., Kenney, Thomas, Koury, Elizabeth, Winneker, Richard C., Deecher, Darlene C., Trybulski, Eugene J.
Published in Bioorganic & medicinal chemistry (2009)

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Journal Article

SUBSTITUTED ARYLAMINE COMPOUNDS, SUBSTITUTED HETEROARYLAMINE COMPOUNDS, AND METHODS USING SAME

SUBSTITUTED ARYLAMINE COMPOUNDS, SUBSTITUTED HETEROARYLAMINE COMPOUNDS, AND METHODS USING SAME

by COLE, Andrew G, SOFIA, Michael J, HEFFERNAN, Gavin D, OZTURK, Seyma, QUINTERO, Jorge G, FAN, Yi
Year of Publication 27.06.2024

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Patent

SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME

SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME

by COLE, Andrew G, HEFFERNAN, Gavin D, OZTURK, Seyma, QUINTERO, Jorge G, FAN, Yi
Year of Publication 04.04.2024

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Patent

SUBSTITUTED IMIDAZOAMIDE COMPOUNDS, AND METHODS USING SAME

SUBSTITUTED IMIDAZOAMIDE COMPOUNDS, AND METHODS USING SAME

by COLE, Andrew G, SOFIA, Michael J, HEFFERNAN, Gavin D, NGUYEN, Duyan, OZTURK, Seyma, QUINTERO, Jorge G, SAKILAM, Satish, FAN, Yi
Year of Publication 25.01.2024

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Patent

SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME

SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME

by Kakarla, Ramesh, Sofia, Michael J, Dorsey, Bruce D, Nguyen, Duyan, Ozturk, Seyma, Heffernan, Gavin D, Kultgen, Steven G, Cole, Andrew G, Ahuja, Vijay, Fan, Yi, Quintero, Jorge
Year of Publication 25.07.2024

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Patent

SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME

SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME

by COLE, Andrew G, KULTGEN, Steven G, DORSEY, Bruce D, SOFIA, Michael J, AHUJA, Vijay, KAKARLA, Ramesh, QUINTERO, Jorge, HEFFERNAN, Gavin D, NGUYEN, Duyan, OZTURK, Seyma, FAN, Yi
Year of Publication 07.02.2024

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Patent

Substituted 1-aryl-1'-heteroaryl compounds, substituted 1,1'-biheteroaryl compounds, and methods using same

Substituted 1-aryl-1'-heteroaryl compounds, substituted 1,1'-biheteroaryl compounds, and methods using same

by COLE Andrew G, KULTGEN Steven G, SOFIA Michael J, DORSEY Bruce D, OZTURK Seyma, QUINTERO Jorge, KAKARLA Ramesh, NGUYEN Duyan, HEFFERNAN Gavin D, FAN Yi, AHUJA Vijay
Year of Publication 01.11.2023

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Patent

SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME

SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME

by COLE, Andrew G, KULTGEN, Steven G, DORSEY, Bruce D, SOFIA, Michael J, AHUJA, Vijay, KAKARLA, Ramesh, QUINTERO, Jorge, HEFFERNAN, Gavin D, NGUYEN, Duyan, OZTURK, Seyma, FAN, Yi
Year of Publication 28.09.2023

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Patent

SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME

SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME

by COLE, Andrew G, KULTGEN, Steven G, DORSEY, Bruce D, SOFIA, Michael J, AHUJA, Vijay, KAKARLA, Ramesh, QUINTERO, Jorge, HEFFERNAN, Gavin D, NGUYEN, Duyan, OZTURK, Seyma, FAN, Yi
Year of Publication 12.01.2023

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Patent