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Turner, Jonathan, Roger, Jan, Fitau, Juliette, Combe, Delphine, Giddings, June, Heeke, Gino Van, Jones, Carol E
Published in American journal of respiratory cell and molecular biology (01.03.2011)
Published in American journal of respiratory cell and molecular biology (01.03.2011)
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Nanobodies and their Use in GPCR Drug Discovery
Cromie, Karen D, Van Heeke, Gino, Boutton, Carlo
Published in Current topics in medicinal chemistry (01.01.2015)
Published in Current topics in medicinal chemistry (01.01.2015)
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Regulation of Neuregulin 1β1–Induced MUC5AC and MUC5B Expression in Human Airway Epithelium
Kettle, Rachel, Simmons, Jennifer, Schindler, Francis, Jones, Peter, Dicker, Tina, Dubois, Gerald, Giddings, June, Van Heeke, Gino, Jones, Carol E.
Published in American journal of respiratory cell and molecular biology (01.04.2010)
Published in American journal of respiratory cell and molecular biology (01.04.2010)
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Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats
Bespalov, Anton Y., Dravolina, Olga A., Sukhanov, Ilya, Zakharova, Elena, Blokhina, Elena, Zvartau, Edwin, Danysz, Wojciech, van Heeke, Gino, Markou, Athina
Published in Neuropharmacology (2005)
Published in Neuropharmacology (2005)
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Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A‐mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)
MacKenzie, Simon J, Baillie, George S, McPhee, Ian, MacKenzie, Carolynn, Seamons, Rachael, McSorley, Theresa, Millen, Jenni, Beard, Matthew B, Heeke, Gino, Houslay, Miles D
Published in British journal of pharmacology (01.06.2002)
Published in British journal of pharmacology (01.06.2002)
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Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers
Barber, Rachael, Baillie, George S, Bergmann, Reinhard, Shepherd, Malcolm C, Sepper, Ruth, Houslay, Miles D, Heeke, Gino Van
Published in American journal of physiology. Lung cellular and molecular physiology (01.08.2004)
Published in American journal of physiology. Lung cellular and molecular physiology (01.08.2004)
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Nanobodies® as inhaled biotherapeutics for lung diseases
Van Heeke, Gino, Allosery, Koen, De Brabandere, Veronique, De Smedt, Tim, Detalle, Laurent, de Fougerolles, Antonin
Published in Pharmacology & therapeutics (Oxford) (01.01.2017)
Published in Pharmacology & therapeutics (Oxford) (01.01.2017)
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RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells
Lynch, Martin J., Baillie, George S., Mohamed, Ahmed, Li, Xiang, Maisonneuve, Charlotte, Klussmann, Enno, van Heeke, Gino, Houslay, Miles D.
Published in The Journal of biological chemistry (30.09.2005)
Published in The Journal of biological chemistry (30.09.2005)
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Treatment with Anti–Gremlin 1 Antibody Ameliorates Chronic Hypoxia/SU5416–Induced Pulmonary Arterial Hypertension in Mice
Ciuclan, Loredana, Sheppard, KellyAnn, Dong, Liqun, Sutton, Daniel, Duggan, Nicholas, Hussey, Martin, Simmons, Jenny, Morrell, Nicholas W, Jarai, Gabor, Edwards, Matthew, DuBois, Gerald, Thomas, Matthew, Van Heeke, Gino, England, Karen
Published in The American journal of pathology (01.11.2013)
Published in The American journal of pathology (01.11.2013)
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Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases
Van Heeke, Gino, Allosery, Koen, De Brabandere, Veronique, De Smedt, Tim, Detalle, Laurent, de Fougerolles, Antonin
Published in Pharmacology & therapeutics (Oxford) (01.01.2017)
Published in Pharmacology & therapeutics (Oxford) (01.01.2017)
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Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion
Cryan, John F., Gasparini, Fabrizio, van Heeke, Gino, Markou, Athina
Published in Drug Discovery Today (15.11.2003)
Published in Drug Discovery Today (15.11.2003)
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In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region
McCahill, Angela, McSorley, Theresa, Huston, Elaine, Hill, Elaine V., Lynch, Martin J., Gall, Irene, Keryer, Guy, Lygren, Birgitte, Tasken, Kjetil, van Heeke, Gino, Houslay, Miles D.
Published in Cellular signalling (01.09.2005)
Published in Cellular signalling (01.09.2005)
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Histidine-49 is necessary for the pH-dependent transition between active and inactive states of the bovine F1-ATPase inhibitor protein
Schnizer, Richard, Van Heeke, Gino, Amaturo, Domenico, Schuster, Sheldon M.
Published in Biochimica et biophysica acta, Protein structure and molecular enzymology (01.02.1996)
Published in Biochimica et biophysica acta, Protein structure and molecular enzymology (01.02.1996)
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Regulation of Neuregulin 1[beta]1-Induced MUC5AC and MUC5B Expression in Human Airway Epithelium
Kettle, Rachel, Simmons, Jennifer, Schindler, Francis, Jones, Peter, Dicker, Tina, Dubois, Gerald, Giddings, June, Van Heeke, Gino, Jones, Carol E
Published in American journal of respiratory cell and molecular biology (01.04.2010)
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Published in American journal of respiratory cell and molecular biology (01.04.2010)
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Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter
Le Jeune, Ivan R, Shepherd, Malcolm, Van Heeke, Gino, Houslay, Miles D, Hall, Ian P
Published in The Journal of biological chemistry (27.09.2002)
Published in The Journal of biological chemistry (27.09.2002)
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Journal Article
RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells
Martin J. Lynch, George S. Baillie, Ahmed Mohamed, Xiang Li, Charlotte Maisonneuve, Enno Klussmann, Gino van Heeke, Miles D. Houslay
Published in The Journal of biological chemistry (30.09.2005)
Published in The Journal of biological chemistry (30.09.2005)
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Journal Article
RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells
Lynch, Martin J, Baillie, George S, Mohamed, Ahmed, Li, Xiang, Maisonneuve, Charlotte, Klussmann, Enno, van Heeke, Gino, Houslay, Miles D
Published in The Journal of biological chemistry (30.09.2005)
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Published in The Journal of biological chemistry (30.09.2005)
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