Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases
Hecker, Scott J, Reddy, K. Raja, Lomovskaya, Olga, Griffith, David C, Rubio-Aparicio, Debora, Nelson, Kirk, Tsivkovski, Ruslan, Sun, Dongxu, Sabet, Mojgan, Tarazi, Ziad, Parkinson, Jonathan, Totrov, Maxim, Boyer, Serge H, Glinka, Tomasz W, Pemberton, Orville A, Chen, Yu, Dudley, Michael N
Published in Journal of medicinal chemistry (23.07.2020)
Published in Journal of medicinal chemistry (23.07.2020)
Get full text
Journal Article
Cu-Catalyzed Decarboxylative Borylation
Wang, Jie, Shang, Ming, Lundberg, Helena, Feu, Karla S, Hecker, Scott J, Qin, Tian, Blackmond, Donna G, Baran, Phil S
Published in ACS catalysis (05.10.2018)
Published in ACS catalysis (05.10.2018)
Get full text
Journal Article
Discovery of a Cyclic Boronic Acid β‑Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases
Hecker, Scott J, Reddy, K. Raja, Totrov, Maxim, Hirst, Gavin C, Lomovskaya, Olga, Griffith, David C, King, Paula, Tsivkovski, Ruslan, Sun, Dongxu, Sabet, Mojgan, Tarazi, Ziad, Clifton, Matthew C, Atkins, Kateri, Raymond, Amy, Potts, Kristy T, Abendroth, Jan, Boyer, Serge H, Loutit, Jeffrey S, Morgan, Elizabeth E, Durso, Stephanie, Dudley, Michael N
Published in Journal of medicinal chemistry (14.05.2015)
Published in Journal of medicinal chemistry (14.05.2015)
Get full text
Journal Article
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
Roberts, Kade D, Zhu, Yan, Azad, Mohammad A K, Han, Mei-Ling, Wang, Jiping, Wang, Lynn, Yu, Heidi H, Horne, Andrew S, Pinson, Jo-Anne, Rudd, David, Voelcker, Nicolas H, Patil, Nitin A, Zhao, Jinxin, Jiang, Xukai, Lu, Jing, Chen, Ke, Lomovskaya, Olga, Hecker, Scott J, Thompson, Philip E, Nation, Roger L, Dudley, Michael N, Griffith, David C, Velkov, Tony, Li, Jian
Published in Nature communications (25.03.2022)
Published in Nature communications (25.03.2022)
Get full text
Journal Article
Selection of QPX7831, an Orally Bioavailable Prodrug of Boronic Acid β‑Lactamase Inhibitor QPX7728
Reddy, K. Raja, Parkinson, Jonathan, Sabet, Mojgan, Tarazi, Ziad, Boyer, Serge H, Lomovskaya, Olga, Griffith, David C, Hecker, Scott J, Dudley, Michael N
Published in Journal of medicinal chemistry (09.12.2021)
Published in Journal of medicinal chemistry (09.12.2021)
Get full text
Journal Article
QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics
Lomovskaya, Olga, Tsivkovski, Ruslan, Sun, Dongxu, Reddy, Raja, Totrov, Maxim, Hecker, Scott, Griffith, David, Loutit, Jeffery, Dudley, Michael
Published in Frontiers in microbiology (05.07.2021)
Published in Frontiers in microbiology (05.07.2021)
Get full text
Journal Article
Methodology for Monobactam Diversification: Syntheses and Studies of 4‑Thiomethyl Substituted β‑Lactams with Activity against Gram-Negative Bacteria, Including Carbapenemase Producing Acinetobacter baumannii
Carosso, Serena, Liu, Rui, Miller, Patricia A, Hecker, Scott J, Glinka, Tomasz, Miller, Marvin J
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
Get full text
Journal Article
Broad-spectrum cyclic boronate β-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability
Raja Reddy, K., Totrov, Maxim, Lomovskaya, Olga, Griffith, David C., Tarazi, Ziad, Clifton, Matthew C., Hecker, Scott J.
Published in Bioorganic & medicinal chemistry (15.05.2022)
Published in Bioorganic & medicinal chemistry (15.05.2022)
Get full text
Journal Article
Scalable Synthesis of β‑Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate
Boyer, Serge H, Gonzalez-de-Castro, Angela, Dielemans, J.A. Hubertus, Lefort, Laurent, Zhu, Zuolin, Gnahn, Matthias, Schörghuber, Julia, Steinhofer, Stefan, de Vries, André H. M, Hecker, Scott J
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
Get full text
Journal Article
Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate
Stueckler, Clemens, Hermsen, Peter, Ritzen, Bas, Vasiloiu, Maria, Poechlauer, Peter, Steinhofer, Stefan, Pelz, Andreas, Zinganell, Christopher, Felfer, Ulfried, Boyer, Serge, Goldbach, Michel, de Vries, André, Pabst, Thomas, Winkler, Georg, LaVopa, Vito, Hecker, Scott, Schuster, Christian
Published in Organic process research & development (17.05.2019)
Published in Organic process research & development (17.05.2019)
Get full text
Journal Article
Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions
Sheeran, Jillian W, Campbell, Kiersten, Breen, Christopher P, Hummel, Gerald, Huang, Changfeng, Datta, Anamika, Boyer, Serge H, Hecker, Scott J, Bio, Matthew M, Fang, Yuan-Qing, Ford, David D, Russell, M. Grace
Published in Organic process research & development (19.03.2021)
Published in Organic process research & development (19.03.2021)
Get full text
Journal Article
Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy
LOMOVSKAYA, Olga, WARREN, Mark S, LEGER, Roger, HECKER, Scott, WATKINS, Will, HOSHINO, Kazuki, ISHIDA, Hiroko, LEE, Ving J, LEE, Angela, GALAZZO, Jorge, FRONKO, Richard, MAY LEE, BLAIS, Johanne, CHO, Deidre, CHAMBERLAND, Suzanne, RENAU, Tom
Published in Antimicrobial Agents and Chemotherapy (01.01.2001)
Published in Antimicrobial Agents and Chemotherapy (01.01.2001)
Get full text
Journal Article
Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees
CARROLL, Steven S, KOEPLINGER, Kenneth, FUJITAKI, James M, BOYER, Serge H, LINEMEYER, David L, HECKER, Scott J, ERION, Mark D, VAVREK, Marissa, NANYAN RENA ZHANG, HANDT, Laurence, MACCOSS, Malcolm, OLSEN, David B, RAJA REDDY, K, ZHILI SUN, VAN POELJE, Paul D
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Get full text
Journal Article
A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis
Gómez-Galeno, Jorge E, Dang, Qun, Nguyen, Thanh H, Boyer, Serge H, Grote, Matthew P, Sun, Zhili, Chen, Mingwei, Craigo, William A, van Poelje, Paul D, MacKenna, Deidre A, Cable, Edward E, Rolzin, Paul A, Finn, Patricia D, Chi, Bert, Linemeyer, David L, Hecker, Scott J, Erion, Mark D
Published in ACS medicinal chemistry letters (09.12.2010)
Published in ACS medicinal chemistry letters (09.12.2010)
Get full text
Journal Article
Synthesis and Biological Evaluation of a Series of Liver-Selective Phosphonic Acid Thyroid Hormone Receptor Agonists and Their Prodrugs
Boyer, Serge H, Jiang, Hongjian, Jacintho, Jason D, Reddy, Mali Venkat, Li, Haiqing, Li, Wenyu, Godwin, Jennifer L, Schulz, William G, Cable, Edward E, Hou, Jinzhao, Wu, Rongrong, Fujitaki, James M, Hecker, Scott J, Erion, Mark D
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
Get full text
Journal Article
Liver-Targeted Prodrugs of 2‘-C-Methyladenosine for Therapy of Hepatitis C Virus Infection
Hecker, Scott J, Reddy, K. Raja, van Poelje, Paul D, Sun, Zhili, Huang, Wenjian, Varkhedkar, Vaibhav, Reddy, M. Venkat, Fujitaki, James M, Olsen, David B, Koeplinger, Kenneth A, Boyer, Serge H, Linemeyer, David L, MacCoss, Malcolm, Erion, Mark D
Published in Journal of medicinal chemistry (09.08.2007)
Published in Journal of medicinal chemistry (09.08.2007)
Get full text
Journal Article
Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents: In Vitro and in Vivo Potency against Pasteurella multocida
McFarland, James W, Berger, Cynthia M, Froshauer, Susan A, Hayashi, Shigeru F, Hecker, Scott J, Jaynes, Burton H, Jefson, Martin R, Kamicker, Barbara J, Lipinski, Christopher A, Lundy, Kristin M, Reese, Catherine P, Vu, Chi B
Published in Journal of medicinal chemistry (25.04.1997)
Published in Journal of medicinal chemistry (25.04.1997)
Get full text
Journal Article
Inhibitors of Efflux Pumps in Pseudomonas aeruginosa Potentiate the Activity of the Fluoroquinolone Antibacterial Levofloxacin
RENAU, Thomas E., LéGER, Roger, FLAMME, Eric M., SANGALANG, Joan, SHE, Miles W., YEN, Rose, GANNON, Carla L., GRIFFITH, David, CHAMBERLAND, Suzanne, LOMOVSKAYA, Olga, HECKER, Scott J., LEE, Ving J., OHTA, Toshiharu, NAKAYAMA, Kiyoshi
Published in Journal of medicinal chemistry (02.12.1999)
Published in Journal of medicinal chemistry (02.12.1999)
Get full text
Journal Article
Stereochemical Elucidation and Total Synthesis of Dihydropacidamycin D, a Semisynthetic Pacidamycin
Boojamra, Constantine G, Lemoine, Rémy C, Lee, Julie C, Léger, Roger, Stein, Karin A, Vernier, Nicole G, Magon, Angela, Lomovskaya, Olga, Martin, Patrick K, Chamberland, Suzanne, Lee, May D, Hecker, Scott J, Lee, Ving J
Published in Journal of the American Chemical Society (07.02.2001)
Published in Journal of the American Chemical Society (07.02.2001)
Get full text
Journal Article