Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model
Vermeersch, Steve, Benschop, Robert J, Van Hecken, Anne, Monteith, David, Wroblewski, Victor J, Grayzel, David, de Hoon, Jan, Collins, Emily C
Published in The Journal of pharmacology and experimental therapeutics (01.09.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2015)
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the CGRP Binding Monoclonal Antibody LY2951742 (Galcanezumab) in Healthy Volunteers
Monteith, David, Collins, Emily C, Vandermeulen, Corinne, Van Hecken, Anne, Raddad, Eyas, Scherer, Joel C, Grayzel, David, Schuetz, Thomas J, de Hoon, Jan
Published in Frontiers in pharmacology (17.10.2017)
Published in Frontiers in pharmacology (17.10.2017)
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Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: A Multiple‐Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers
Postnov, Andrey, Schmidt, Mark E., Pemberton, Darrel J., Hoon, Jan, Hecken, Anne, den Boer, Maarten, Zannikos, Peter, der Ark, Peter, Palmer, James A., Rassnick, Stef, Celen, Sofie, Bormans, Guy, Laere, Koen
Published in Clinical and translational science (01.07.2018)
Published in Clinical and translational science (01.07.2018)
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First‐in‐human development of a pharmacodynamic biomarker for PAC1 receptor antagonists using intradermal injections of maxadilan
Marynissen, Heleen, Buntinx, Linde, Bamps, Dorien, Depre, Marleen, Ampe, Els, Van Hecken, Anne, Gabriel, Kristin, Sands, Steve, Vargas, Gabriel, de Hoon, Jan
Published in Clinical and translational science (01.08.2022)
Published in Clinical and translational science (01.08.2022)
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Relative Bioavailability of Enalapril Administered as Orodispersible Minitablets in Healthy Adults
Van Hecken, Anne, Burckhardt, Björn B., Khalil, Feras, Hoon, Jan, Klingmann, Ingrid, Herbots, Marissa, Laeer, Stephanie, Lagler, Florian B., Breitkreutz, Jörg
Published in Clinical pharmacology in drug development (01.02.2020)
Published in Clinical pharmacology in drug development (01.02.2020)
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Inhibition of capsaicin‐induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK‐0974)
Sinclair, Simon R., Kane, Stefanie A., Van der Schueren, Bart J., Xiao, Alan, Willson, Kenneth J., Boyle, Janet, De Lepeleire, Inge, Xu, Yang, Hickey, Lisa, Denney, William S., Li, Chi‐Chung, Palcza, John, Vanmolkot, Floris H. M., Depré, Marleen, Van Hecken, Anne, Murphy, M. Gail, Ho, Tony W., De Hoon, Jay N.
Published in British journal of clinical pharmacology (01.01.2010)
Published in British journal of clinical pharmacology (01.01.2010)
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Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion
Six, Karel, Daems, Tinne, de Hoon, Jan, Van Hecken, Anne, Depre, Marleen, Bouche, Marie-Paule, Prinsen, Paul, Verreck, Geert, Peeters, Jef, Brewster, Marcus E., Van den Mooter, Guy
Published in European journal of pharmaceutical sciences (01.02.2005)
Published in European journal of pharmaceutical sciences (01.02.2005)
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Pharmacokinetic-Pharmacodynamic Relationship of Erenumab (AMG 334) and Capsaicin-Induced Dermal Blood Flow in Healthy and Migraine Subjects
Vu, Thuy, Ma, Peiming, Chen, Jiyun Sunny, de Hoon, Jan, Van Hecken, Anne, Yan, Lucy, Wu, Liviawati Sutjandra, Hamilton, Lisa, Vargas, Gabriel
Published in Pharmaceutical research (01.09.2017)
Published in Pharmaceutical research (01.09.2017)
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Phase 1, randomized, parallel-group, double-blind, placebo-controlled trial to evaluate the effects of erenumab (AMG 334) and concomitant sumatriptan on blood pressure in healthy volunteers
de Hoon, Jan, Van Hecken, Anne, Vandermeulen, Corinne, Herbots, Marissa, Kubo, Yumi, Lee, Ed, Eisele, Osa, Vargas, Gabriel, Gabriel, Kristin
Published in Cephalalgia (01.01.2019)
Published in Cephalalgia (01.01.2019)
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Phase I, Randomized, Double-blind, Placebo-controlled, Single-dose, and Multiple-dose Studies of Erenumab in Healthy Subjects and Patients With Migraine
de Hoon, Jan, Van Hecken, Anne, Vandermeulen, Corinne, Yan, Lucy, Smith, Brian, Chen, Jiyun Sunny, Bautista, Edgar, Hamilton, Lisa, Waksman, Javier, Vu, Thuy, Vargas, Gabriel
Published in Clinical pharmacology and therapeutics (01.05.2018)
Published in Clinical pharmacology and therapeutics (01.05.2018)
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TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde‐Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology
Bamps, Dorien, Blockeel, Anthony James, Dreesen, Erwin, Marynissen, Heleen, Laenen, Jolien, Van Hecken, Anne, Wilke, August, Shahabi, Shahram, Johnson, Kirk W., Collins, Emily Catherine, Broad, Lisa M., Phillips, Keith G., Hoon, Jan
Published in Clinical pharmacology and therapeutics (01.11.2023)
Published in Clinical pharmacology and therapeutics (01.11.2023)
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In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232
Hostetler, Eric D, Joshi, Aniket D, Sanabria-Bohórquez, Sandra, Fan, Hong, Zeng, Zhizhen, Purcell, Mona, Gantert, Liza, Riffel, Kerry, Williams, Mangay, O'Malley, Stacey, Miller, Patricia, Selnick, Harold G, Gallicchio, Steven N, Bell, Ian M, Salvatore, Christopher A, Kane, Stefanie A, Li, Chi-Chung, Hargreaves, Richard J, de Groot, Tjibbe, Bormans, Guy, Van Hecken, Anne, Derdelinckx, Inge, de Hoon, Jan, Reynders, Tom, Declercq, Ruben, De Lepeleire, Inge, Kennedy, W P, Blanchard, Rebecca, Marcantonio, Eugene E, Sur, Cyrille, Cook, Jacquelynn J, Van Laere, Koen, Evelhoch, Jeffrey L
Published in The Journal of pharmacology and experimental therapeutics (01.11.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2013)
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First-in-human development of a pharmacodynamic biomarker for PAC 1 receptor antagonists using intradermal injections of maxadilan
Marynissen, Heleen, Buntinx, Linde, Bamps, Dorien, Depre, Marleen, Ampe, Els, Van Hecken, Anne, Gabriel, Kristin, Sands, Steve, Vargas, Gabriel, de Hoon, Jan
Published in Clinical and translational science (01.08.2022)
Published in Clinical and translational science (01.08.2022)
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Effect of montelukast on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers
Van Hecken, A, Depré, M, Verbesselt, R, Wynants, K, De Lepeleire, I, Arnout, J, Wong, P H, Freeman, A, Holland, S, Gertz, B, De Schepper, P J
Published in Journal of clinical pharmacology (01.05.1999)
Published in Journal of clinical pharmacology (01.05.1999)
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[¹⁸F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
Burns, H. Donald, Van Laere, Koen, Sanabria-Bohórquez, Sandra, Hamill, Terence G, Bormans, Guy, Eng, Wai-si, Gibson, Ray, Ryan, Christine, Connolly, Brett, Patel, Shil, Krause, Stephen, Vanko, Amy, Van Hecken, Anne, Dupont, Patrick, De Lepeleire, Inge, Rothenberg, Paul, Stoch, S. Aubrey, Cote, Josee, Hagmann, William K, Jewell, James P, Lin, Linus S, Liu, Ping, Goulet, Mark T, Gottesdiener, Keith, Wagner, John A, de Hoon, Jan, Mortelmans, Luc, Fong, Tung M, Hargreaves, Richard J
Published in Proceedings of the National Academy of Sciences - PNAS (05.06.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (05.06.2007)
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What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of 11 C-JNJ-42491293, A Novel Radioligand for mGluR2
Leurquin-Sterk, Gil, Celen, Sofie, Van Laere, Koen, Koole, Michel, Bormans, Guy, Langlois, Xavier, Van Hecken, Anne, te Riele, Paula, Alcázar, Jesús, Verbruggen, Alfons, de Hoon, Jan, Andrés, Jose-Ignacio, Schmidt, Mark E.
Published in Journal of Nuclear Medicine (01.01.2017)
Published in Journal of Nuclear Medicine (01.01.2017)
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Effect of multiple doses of montelukast, a CysLT1 receptor antagonist, on digoxin pharmacokinetics in healthy volunteers
Depré, M, Van Hecken, A, Verbesselt, R, Wynants, K, De Lepeleire, I, Freeman, A, Holland, S, Shahane, A, Gertz, B, De Schepper, P J
Published in Journal of clinical pharmacology (01.09.1999)
Published in Journal of clinical pharmacology (01.09.1999)
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A quality control system for ligand-binding assay of plasma renin activity: Proof-of-concept within a pharmacodynamic study
Suessenbach, Fabian Konstantin, Makowski, Nina, Feickert, Martin, Gangnus, Tanja, Tins, Jutta, Burckhardt, Bjoern Bengt, Läer, Stephanie, Breitkreutz, Jörg, Klingmann, Ingrid, Lagler, Florian, de Hoon, Jan, Dalinghaus, Michiel, Bajcetic, Milica, de Wildt, Saskia, Clarke, Anne Keatley, Breur, Johannes, Male, Christoph, Ablonczy, Laslo, Mir, Thomas, Vukomanovic, Vladislav, Dukic, Milan, Jovanovic, Ida, Burckhardt, Bjoern B., Cawello, Willi, Kleine, Karl, Moder, Angelika, Obarcanin, Emina, Wagner, Peter, Walsh, Jennifer, van Hecken, Anne, Spatenkova, Lucie, Ali, Mohsin, Božić, Bojana, Burdman, Maja Bijelić Ilja, Ciplea, Agnes, Faisal, Muhammad, Farahani, Samieh, Lazic, Milica, Suessenbach, Fabian, van der Meulen, Marijke, Popović, Saša, Parezanović, Miro, Smeets, Nori, Swoboda, Vanessa, Bojanin, Dragana, Đorđević, Stefan, Dragić, Jasminka, Holle, Ann-Kathrin, Jovičić, Bosiljka, Košutić, Jovan, Kozomara, Gordana, Majid, Haidara, Mitrović, Jadranka, Ninić, Sanja, Parezanovic, Miro, Parezanovic, Vojislav, Pavlović, Andrija, Prijić, Sergej, Rebić, Branislava, Stefanović, Igor, Tordas, Daniel, Vulićević, Irena, Bartels, Anke, Čeko, Andjelka, Herborts, Marissa, Hennink, Annelies, Kosanović, Bosiljka, Kostic, Sanja, Isailović, Ljiljana, Maksimovic, Jasmina, Manai, Badies, Martinović, Nada, Máté, Gyöngyi, Perišić, Miloš, Reljić, Jelena, Salamomovic, Regina Pirker Marta, Schlesner, Claudia, Wissmann, Eva
Published in Journal of pharmaceutical and biomedical analysis (20.03.2020)
Published in Journal of pharmaceutical and biomedical analysis (20.03.2020)
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Model-dependent pharmacokinetic analysis of enalapril administered to healthy adult volunteers using orodispersible minitablets for use in pediatrics
Faisal, Muhammad, Cawello, Willi, Burckhardt, Bjoern B, Laer, Stephanie
Published in Drug design, development and therapy (01.01.2019)
Published in Drug design, development and therapy (01.01.2019)
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