CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
Spencer, David H., Russler-Germain, David A., Ketkar, Shamika, Helton, Nichole M., Lamprecht, Tamara L., Fulton, Robert S., Fronick, Catrina C., O’Laughlin, Michelle, Heath, Sharon E., Shinawi, Marwan, Westervelt, Peter, Payton, Jacqueline E., Wartman, Lukas D., Welch, John S., Wilson, Richard K., Walter, Matthew J., Link, Daniel C., DiPersio, John F., Ley, Timothy J.
Published in Cell (23.02.2017)
Published in Cell (23.02.2017)
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Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential
Wong, Terrence N, Miller, Christopher A, Jotte, Matthew R M, Bagegni, Nusayba, Baty, Jack D, Schmidt, Amy P, Cashen, Amanda F, Duncavage, Eric J, Helton, Nichole M, Fiala, Mark, Fulton, Robert S, Heath, Sharon E, Janke, Megan, Luber, Kierstin, Westervelt, Peter, Vij, Ravi, DiPersio, John F, Welch, John S, Graubert, Timothy A, Walter, Matthew J, Ley, Timothy J, Link, Daniel C
Published in Nature communications (31.01.2018)
Published in Nature communications (31.01.2018)
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Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML
Wong, Terrence N., Miller, Christopher A., Klco, Jeffery M., Petti, Allegra, Demeter, Ryan, Helton, Nichole M., Li, Tiandao, Fulton, Robert S., Heath, Sharon E., Mardis, Elaine R., Westervelt, Peter, DiPersio, John F., Walter, Matthew J., Welch, John S., Graubert, Timothy A., Wilson, Richard K., Ley, Timothy J., Link, Daniel C.
Published in Blood (18.02.2016)
Published in Blood (18.02.2016)
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Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome
Smith, Amanda M, LaValle, Taylor A, Shinawi, Marwan, Ramakrishnan, Sai M, Abel, Haley J, Hill, Cheryl A, Kirkland, Nicole M, Rettig, Michael P, Helton, Nichole M, Heath, Sharon E, Ferraro, Francesca, Chen, David Y, Adak, Sangeeta, Semenkovich, Clay F, Christian, Diana L, Martin, Jenna R, Gabel, Harrison W, Miller, Christopher A, Ley, Timothy J
Published in Nature communications (27.07.2021)
Published in Nature communications (27.07.2021)
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Lenalidomide results in a durable complete remission in acute myeloid leukemia accompanied by persistence of somatic mutations and a T-cell infiltrate in the bone marrow
Bansal, Dhruv, Vij, Kiran, Chang, Gue Su, Miller, Christopher A, DiPersio, John F, Vij, Ravi, Heath, Sharon E, Westervelt, Peter, Welch, John S, Fehniger, Todd A
Published in Haematologica (Roma) (01.06.2018)
Published in Haematologica (Roma) (01.06.2018)
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Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant
Jacoby, Meagan A, Duncavage, Eric J, Chang, Gue Su, Miller, Christopher A, Shao, Jin, Elliott, Kevin, Robinson, Joshua, Fulton, Robert S, Fronick, Catrina C, O'Laughlin, Michelle, Heath, Sharon E, Pusic, Iskra, Welch, John S, Link, Daniel C, DiPersio, John F, Westervelt, Peter, Ley, Timothy J, Graubert, Timothy A, Walter, Matthew J
Published in JCI insight (08.03.2018)
Published in JCI insight (08.03.2018)
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Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers
Duncavage, Eric J, Schroeder, Molly C, O’Laughlin, Michele, Wilson, Roxanne, MacMillan, Sandra, Bohannon, Andrew, Kruchowski, Scott, Garza, John, Du, Feiyu, Hughes, Andrew E.O, Robinson, Josh, Hughes, Emma, Heath, Sharon E, Baty, Jack D, Neidich, Julie, Christopher, Matthew J, Jacoby, Meagan A, Uy, Geoffrey L, Fulton, Robert S, Miller, Christopher A, Payton, Jacqueline E, Link, Daniel C, Walter, Matthew J, Westervelt, Peter, DiPersio, John F, Ley, Timothy J, Spencer, David H
Published in The New England journal of medicine (11.03.2021)
Published in The New England journal of medicine (11.03.2021)
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Immune Escape of Relapsed AML Cells after Allogeneic Transplantation
Christopher, Matthew J, Petti, Allegra A, Rettig, Michael P, Miller, Christopher A, Chendamarai, Ezhilarasi, Duncavage, Eric J, Klco, Jeffery M, Helton, Nicole M, O’Laughlin, Michelle, Fronick, Catrina C, Fulton, Robert S, Wilson, Richard K, Wartman, Lukas D, Welch, John S, Heath, Sharon E, Baty, Jack D, Payton, Jacqueline E, Graubert, Timothy A, Link, Daniel C, Walter, Matthew J, Westervelt, Peter, Ley, Timothy J, DiPersio, John F
Published in The New England journal of medicine (13.12.2018)
Published in The New England journal of medicine (13.12.2018)
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The Origin and Evolution of Mutations in Acute Myeloid Leukemia
Welch, John S., Ley, Timothy J., Link, Daniel C., Miller, Christopher A., Larson, David E., Koboldt, Daniel C., Wartman, Lukas D., Lamprecht, Tamara L., Liu, Fulu, Xia, Jun, Kandoth, Cyriac, Fulton, Robert S., McLellan, Michael D., Dooling, David J., Wallis, John W., Chen, Ken, Harris, Christopher C., Schmidt, Heather K., Kalicki-Veizer, Joelle M., Lu, Charles, Zhang, Qunyuan, Lin, Ling, O’Laughlin, Michelle D., McMichael, Joshua F., Delehaunty, Kim D., Fulton, Lucinda A., Magrini, Vincent J., McGrath, Sean D., Demeter, Ryan T., Vickery, Tammi L., Hundal, Jasreet, Cook, Lisa L., Swift, Gary W., Reed, Jerry P., Alldredge, Patricia A., Wylie, Todd N., Walker, Jason R., Watson, Mark A., Heath, Sharon E., Shannon, William D., Varghese, Nobish, Nagarajan, Rakesh, Payton, Jacqueline E., Baty, Jack D., Kulkarni, Shashikant, Klco, Jeffery M., Tomasson, Michael H., Westervelt, Peter, Walter, Matthew J., Graubert, Timothy A., DiPersio, John F., Ding, Li, Mardis, Elaine R., Wilson, Richard K.
Published in Cell (20.07.2012)
Published in Cell (20.07.2012)
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Mutation Clearance after Transplantation for Myelodysplastic Syndrome
Duncavage, Eric J, Jacoby, Meagan A, Chang, Gue Su, Miller, Christopher A, Edwin, Natasha, Shao, Jin, Elliott, Kevin, Robinson, Joshua, Abel, Haley, Fulton, Robert S, Fronick, Catrina C, O’Laughlin, Michelle, Heath, Sharon E, Brendel, Kimberly, Saba, Raya, Wartman, Lukas D, Christopher, Matthew J, Pusic, Iskra, Welch, John S, Uy, Geoffrey L, Link, Daniel C, DiPersio, John F, Westervelt, Peter, Ley, Timothy J, Trinkaus, Kathryn, Graubert, Timothy A, Walter, Matthew J
Published in The New England journal of medicine (13.09.2018)
Published in The New England journal of medicine (13.09.2018)
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Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells
Wilson, Elisabeth R, Helton, Nichole M, Heath, Sharon E, Fulton, Robert S, Payton, Jacqueline E, Welch, John S, Walter, Matthew J, Westervelt, Peter, DiPersio, John F, Link, Daniel C, Miller, Christopher A, Ley, Timothy J, Spencer, David H
Published in Leukemia (01.04.2022)
Published in Leukemia (01.04.2022)
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Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes
Ferraro, Francesca, Miller, Christopher A, Christensen, Keegan A, Helton, Nichole M, O'Laughlin, Margaret, Fronick, Catrina C, Fulton, Robert S, Kohlschmidt, Jessica, Eisfeld, Ann-Kathrin, Bloomfield, Clara D, Ramakrishnan, Sai Mukund, Day, Ryan B, Wartman, Lukas D, Uy, Geoffrey L, Welch, John S, Christopher, Matthew J, Heath, Sharon E, Baty, Jack D, Schuelke, Matthew J, Payton, Jacqueline E, Spencer, David H, Rettig, Michael P, Link, Daniel C, Walter, Matthew J, Westervelt, Peter, DiPersio, John F, Ley, Timothy J
Published in Proceedings of the National Academy of Sciences - PNAS (07.12.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (07.12.2021)
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DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults
Ferris, Margaret A., Smith, Amanda M., Heath, Sharon E., Duncavage, Eric J., Oberley, Matthew, Freyer, David, Wynn, Robert, Douzgou, Sofia, Maris, John M., Reilly, Anne F., Wu, Melinda D., Choo, Florence, Fiets, Roel B., Koene, Saskia, Spencer, David H., Miller, Christopher A., Shinawi, Marwan, Ley, Timothy J.
Published in Blood (20.01.2022)
Published in Blood (20.01.2022)
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IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function
Li, Sidan, Yao, Juo-Chin, Oetjen, Karolyn A., Krambs, Joseph R., Xia, Jun, Zhang, Jingzhu, Schmidt, Amy P., Helton, Nichole M., Fulton, Robert S., Heath, Sharon E., Turnbull, Isaiah R., Mbalaviele, Gabriel, Ley, Timothy J., Walter, Matthew J., Link, Daniel C.
Published in Blood (06.10.2022)
Published in Blood (06.10.2022)
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Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia
Griffith, Malachi, Griffith, Obi L, Krysiak, Kilannin, Skidmore, Zachary L, Christopher, Matthew J, Klco, Jeffery M, Ramu, Avinash, Lamprecht, Tamara L, Wagner, Alex H, Campbell, Katie M, Lesurf, Robert, Hundal, Jasreet, Zhang, Jin, Spies, Nicholas C, Ainscough, Benjamin J, Larson, David E, Heath, Sharon E, Fronick, Catrina, O'Laughlin, Shelly, Fulton, Robert, Magrini, Vincent, McGrath, Sean, Smith, Scott M, Miller, Christopher A, Maher, Christopher A, Payton, Jacqueline E, Walker, Jason R, Eldred, James M, Walter, Matthew J, Link, Daniel C, Graubert, Timothy A, Westervelt, Peter, Kulkarni, Shashikant, DiPersio, John F, Mardis, Elaine R, Wilson, Richard K, Ley, Timothy J
Published in Experimental hematology (01.07.2016)
Published in Experimental hematology (01.07.2016)
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Genomic landscape of TP53-mutated myeloid malignancies
Abel, Haley J., Oetjen, Karolyn A., Miller, Christopher A., Ramakrishnan, Sai M., Day, Ryan B., Helton, Nichole M., Fronick, Catrina C., Fulton, Robert S., Heath, Sharon E., Tarnawsky, Stefan P., Nonavinkere Srivatsan, Sridhar, Duncavage, Eric J., Schroeder, Molly C., Payton, Jacqueline E., Spencer, David H., Walter, Matthew J., Westervelt, Peter, DiPersio, John F., Ley, Timothy J., Link, Daniel C.
Published in Blood advances (22.08.2023)
Published in Blood advances (22.08.2023)
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Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
Petti, Allegra A, Khan, Saad M, Xu, Ziheng, Helton, Nichole, Fronick, Catrina C, Fulton, Robert, Ramakrishnan, Sai M, Nonavinkere Srivatsan, Sridhar, Heath, Sharon E, Westervelt, Peter, Payton, Jacqueline E, Walter, Matthew J, Link, Daniel C, DiPersio, John, Miller, Christopher, Ley, Timothy J
Published in Blood cancer discovery (01.01.2022)
Published in Blood cancer discovery (01.01.2022)
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Melanoma in a patient with DNMT3A overgrowth syndrome
Chen, David Y, Sutton, Leslie A, Ramakrishnan, Sai Mukund, Duncavage, Eric J, Heath, Sharon E, Compton, Leigh A, Miller, Christopher A, Ley, Timothy J
Published in Cold Spring Harbor molecular case studies (01.04.2023)
Published in Cold Spring Harbor molecular case studies (01.04.2023)
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Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression
Menssen, Andrew J, Khanna, Ajay, Miller, Christopher A, Nonavinkere Srivatsan, Sridhar, Chang, Gue Su, Shao, Jin, Robinson, Joshua, O'Laughlin, Michele, Fronick, Catrina C, Fulton, Robert S, Brendel, Kimberly, Heath, Sharon E, Saba, Raya, Welch, John S, Spencer, David H, Payton, Jacqueline E, Westervelt, Peter, DiPersio, John F, Link, Daniel C, Schuelke, Matthew J, Jacoby, Meagan A, Duncavage, Eric J, Ley, Timothy J, Walter, Matthew J
Published in Blood cancer discovery (06.07.2022)
Published in Blood cancer discovery (06.07.2022)
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Identification of somatic JAK1 mutations in patients with acute myeloid leukemia
Xiang, Zhifu, Zhao, Yu, Mitaksov, Vesselin, Fremont, Daved H., Kasai, Yumi, Molitoris, AnnaLynn, Ries, Rhonda E., Miner, Tracie L., McLellan, Michael D., DiPersio, John F., Link, Daniel C., Payton, Jacqueline E., Graubert, Timothy A., Watson, Mark, Shannon, William, Heath, Sharon E., Nagarajan, Rakesh, Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J., Tomasson, Michael H.
Published in Blood (01.05.2008)
Published in Blood (01.05.2008)
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