Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
Hoffman, Robert L, Kania, Robert S, Brothers, Mary A, Davies, Jay F, Ferre, Rose A, Gajiwala, Ketan S, He, Mingying, Hogan, Robert J, Kozminski, Kirk, Li, Lilian Y, Lockner, Jonathan W, Lou, Jihong, Marra, Michelle T, Mitchell, Lennert J, Murray, Brion W, Nieman, James A, Noell, Stephen, Planken, Simon P, Rowe, Thomas, Ryan, Kevin, Smith, George J, Solowiej, James E, Steppan, Claire M, Taggart, Barbara
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib
Huang, Qinhua, Johnson, Ted W, Bailey, Simon, Brooun, Alexei, Bunker, Kevin D, Burke, Benjamin J, Collins, Michael R, Cook, Andrew S, Cui, J. Jean, Dack, Kevin N, Deal, Judith G, Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D, He, Mingying, Hoffman, Jacqui, Hoffman, Robert L, Johnson, Patrick S, Kania, Robert S, Lam, Hieu, Lam, Justine L, Le, Phuong T, Li, Qiuhua, Lingardo, Laura, Liu, Wei, Lu, Melissa West, McTigue, Michele, Palmer, Cynthia L, Richardson, Paul F, Sach, Neal W, Shen, Hong, Smeal, Tod, Smith, Graham L, Stewart, Albert E, Timofeevski, Sergei, Tsaparikos, Konstantinos, Wang, Hui, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y, Edwards, Martin P
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Optimization of Medium Composition and Culture Conditions for Cell Multiplication of a High Quality Milk Beer Fermentation Yeast (Kluyveromyces marxianus)
Wang, Liang, He, Yuting, Swanson, Clifford S., He, Qiang, Mintah, Benjamin Kumah, Gao, Enyan, Zheng, Xiaoyan, He, Mingying
Published in FOOD SCIENCE AND TECHNOLOGY RESEARCH (01.01.2020)
Published in FOOD SCIENCE AND TECHNOLOGY RESEARCH (01.01.2020)
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Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
Pfefferkorn, Jeffrey A., Lou, Jihong, Minich, Martha L., Filipski, Kevin J., He, Mingying, Zhou, Ru, Ahmed, Syed, Benbow, John, Perez, Angel-Guzman, Tu, Meihua, Litchfield, John, Sharma, Raman, Metzler, Karen, Bourbonais, Francis, Huang, Cong, Beebe, David A., Oates, Peter J.
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
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Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors
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Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Palladium(ii)-catalyzed -selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
Matsuura, Rei, Jankins, Tanner C., Hill, David E., Yang, Kin S., Gallego, Gary M., Yang, Shouliang, He, Mingying, Wang, Fen, Marsters, Rohan P., McAlpine, Indrawan, Engle, Keary M.
Published in Chemical science (Cambridge) (28.11.2018)
Published in Chemical science (Cambridge) (28.11.2018)
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Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations
Johnson, Ted W., Richardson, Paul F., Bailey, Simon, Brooun, Alexei, Burke, Benjamin J., Collins, Michael R., Cui, J. Jean, Deal, Judith G., Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D., He, Mingying, Hoffman, Jacqui, Hoffman, Robert L., Huang, Qinhua, Kania, Robert S., Kath, John C., Lam, Hieu, Lam, Justine L., Le, Phuong T., Lingardo, Laura, Liu, Wei, McTigue, Michele, Palmer, Cynthia L., Sach, Neal W., Smeal, Tod, Smith, Graham L., Stewart, Albert E., Timofeevski, Sergei, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y., Edwards, Martin P.
Published in Journal of medicinal chemistry (12.06.2014)
Published in Journal of medicinal chemistry (12.06.2014)
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Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
Matsuura, Rei, Jankins, Tanner C, Hill, David E, Yang, Kin S, Gallego, Gary M, Yang, Shouliang, He, Mingying, Wang, Fen, Marsters, Rohan P, McAlpine, Indrawan, Engle, Keary M
Published in Chemical science (Cambridge) (28.11.2018)
Published in Chemical science (Cambridge) (28.11.2018)
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Screening of the freeze‐drying protective agent for high‐quality milk beer yeast (Kluyveromyces marxianus) and optimization of freeze‐drying process conditions
Wang, Liang, He, Mingying, Wu, Tao, Yang, Kangye, Wang, Yulian, Zhang, Yi, Gu, Yachun, Deng, Kaiwen
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Design and Synthesis of Functionally Active 5‑Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
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Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acidsElectronic supplementary information (ESI) available. CCDC 1835959. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8sc03081b
Matsuura, Rei, Jankins, Tanner C, Hill, David E, Yang, Kin S, Gallego, Gary M, Yang, Shouliang, He, Mingying, Wang, Fen, Marsters, Rohan P, McAlpine, Indrawan, Engle, Keary M
Year of Publication 14.11.2018
Year of Publication 14.11.2018
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Clinical and genetic analysis of children with glucose transporter type 1 deficiency syndrome
Qian, Hao, Ying, Guohuan, Xu, Haifeng, Wang, Shangyu, Wu, Bing, Wang, Xin, Qi, Hongdan, He, Mingying, Ud Din, M Jalal, Huang, Tingting, Wu, Yimei, Zhang, Gang
Published in Medicine international (London) (01.11.2024)
Published in Medicine international (London) (01.11.2024)
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Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids† †Electronic supplementary information (ESI) available. CCDC 1835959. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8sc03081b
Matsuura, Rei, Jankins, Tanner C., Hill, David E., Yang, Kin S., Gallego, Gary M., Yang, Shouliang, He, Mingying, Wang, Fen, Marsters, Rohan P., McAlpine, Indrawan, Engle, Keary M.
Published in Chemical science (Cambridge) (06.09.2018)
Published in Chemical science (Cambridge) (06.09.2018)
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Abstract PR10: Is CNS availability for oncology a no-brainer? Discovery of PF-06463922, a novel small molecule inhibitor of ALK/ROS1 with preclinical brain availability and broad spectrum potency against ALK-resistant mutations
Johnson, Ted W., Bailey, Simon, Burke, Benjamin J., Collins, Michael R., Cui, J. Jean, Deal, Judy, Deng, Ya-Li, Edwards, Martin P., He, Mingying, Hoffman, Jacqui, Hoffman, Robert L., Huang, Qinhua, Kania, Robert S., Le, Phuong, McTigue, Michele, Palmer, Cynthia L., Richardson, Paul F., Sach, Neal W., Smith, Graham L., Engstrom, Lars, Hu, Wenyue, Lam, Hieu, Lam, Justine L., Smeal, Tod, Zou, Helen Y.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Steady-State and Pre-Steady-State Kinetic Evaluation of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL pro Cysteine Protease: Development of an Ion-Pair Model for Catalysis
Solowiej, James, Thomson, James A., Ryan, Kevin, Luo, Chun, He, Mingying, Lou, Jihong, Murray, Brion W.
Published in Biochemistry (Easton) (01.02.2008)
Published in Biochemistry (Easton) (01.02.2008)
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Steady-State and Pre-Steady-State Kinetic Evaluation of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL super(pro) Cysteine Protease: Development of an Ion-Pair Model for Catalysis
Solowiej, James, Thomson, James A, Ryan, Kevin, Luo, Chun, He, Mingying, Lou, Jihong, Murray, Brion W
Published in Biochemistry (Easton) (01.01.2008)
Published in Biochemistry (Easton) (01.01.2008)
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Azalactam Compounds as HPK1 Inhibitors
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Year of Publication 20.06.2024
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Year of Publication 20.06.2024
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2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
Zhou, Ru, Zhou, Dahui, Gallego, Rebecca Anne, Del Bel, Matthew L, He, Mingying, Ahmad, Omar Khaled, Tuttle, Jamison Bryce, Johnson, Ted William, Mctigue, Michele Ann, Nair, Sajiv Krishnan, Jalaie, Mehran, Schmitt, Anne-Marie Dechert, Kania, Robert Steven
Year of Publication 22.12.2023
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Year of Publication 22.12.2023
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Azalactam compounds as HPK1 inhibitors
Zhou, Ru, Zhou, Dahui, Gallego, Rebecca Anne, Del Bel, Matthew L, He, Mingying, Barber, Joyann, Tuttle, Jamison Bryce, Jalaie, Mehran, Nair, Sajiv Krishnan, Schmitt, Anne-Marie Dechert, Kania, Robert Steven, Cho-Schultz, Sujin, McTigue, Michele Ann
Year of Publication 27.06.2023
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Year of Publication 27.06.2023
Patent