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High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
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Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
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Published in Molecular cancer therapeutics (01.07.2009)
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Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases
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Published in Cancer research (Chicago, Ill.) (15.06.2007)
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Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)
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Published in Journal of medicinal chemistry (27.12.2013)
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Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone
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Published in Journal of medicinal chemistry (13.08.2009)
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ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma
Carvalho, Diana, Taylor, Kathryn R., Olaciregui, Nagore Gene, Molinari, Valeria, Clarke, Matthew, Mackay, Alan, Ruddle, Ruth, Henley, Alan, Valenti, Melanie, Hayes, Angela, Brandon, Alexis De Haven, Eccles, Suzanne A., Raynaud, Florence, Boudhar, Aicha, Monje, Michelle, Popov, Sergey, Moore, Andrew S., Mora, Jaume, Cruz, Ofelia, Vinci, Mara, Brennan, Paul E., Bullock, Alex N., Carcaboso, Angel Montero, Jones, Chris
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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
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FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas
Milton, Christopher I., Selfe, Joanna, Aladowicz, Ewa, Man, Stella Y. K., Bernauer, Carolina, Missiaglia, Edoardo, Walters, Zoë S., Gatz, Susanne A., Kelsey, Anna, Generali, Melanie, Box, Gary, Valenti, Melanie, Haven‐Brandon, Alexis, Galiwango, David, Hayes, Angela, Clarke, Matthew, Izquierdo, Elisa, Gonzalez De Castro, David, Raynaud, Florence I., Kirkin, Vladimir, Shipley, Janet M.
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Reconstruction of sea-surface temperatures from assemblages of planktonic foraminifera: multi-technique approach based on geographically constrained calibration data sets and its application to glacial Atlantic and Pacific Oceans
Kucera, Michal, Weinelt, Mara, Kiefer, Thorsten, Pflaumann, Uwe, Hayes, Angela, Weinelt, Martin, Chen, Min-Te, Mix, Alan C., Barrows, Timothy T., Cortijo, Elsa, Duprat, Josette, Juggins, Steve, Waelbroeck, Claire
Published in Quaternary science reviews (01.04.2005)
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C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays
Le Bihan, Yann-Vaï, Lanigan, Rachel M., Atrash, Butrus, McLaughlin, Mark G., Velupillai, Srikannathasan, Malcolm, Andrew G., England, Katherine S., Ruda, Gian Filippo, Mok, N. Yi, Tumber, Anthony, Tomlin, Kathy, Saville, Harry, Shehu, Erald, McAndrew, Craig, Carmichael, LeAnne, Bennett, James M., Jeganathan, Fiona, Eve, Paul, Donovan, Adam, Hayes, Angela, Wood, Francesca, Raynaud, Florence I., Fedorov, Oleg, Brennan, Paul E., Burke, Rosemary, van Montfort, Rob L.M., Rossanese, Olivia W., Blagg, Julian, Bavetsias, Vassilios
Published in European journal of medicinal chemistry (01.09.2019)
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Synthesis of a benzoxazinthione derivative of tanaproget and pharmacological evaluation for PET imaging of PR expression
Allott, Louis, Miranda, Cecilia, Hayes, Angela, Raynaud, Florence, Cawthorne, Christopher, Smith, Graham
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Published in EJNMMI radiopharmacy and chemistry (10.01.2019)
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iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells
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Published in iScience (21.07.2023)
Published in iScience (21.07.2023)
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Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
Sharp, Swee Y, Prodromou, Chrisostomos, Boxall, Kathy, Powers, Marissa V, Holmes, Joanna L, Box, Gary, Matthews, Thomas P, Cheung, Kwai-Ming J, Kalusa, Andrew, James, Karen, Hayes, Angela, Hardcastle, Anthea, Dymock, Brian, Brough, Paul A, Barril, Xavier, Cansfield, Julie E, Wright, Lisa, Surgenor, Allan, Foloppe, Nicolas, Hubbard, Roderick E, Aherne, Wynne, Pearl, Laurence, Jones, Keith, McDonald, Edward, Raynaud, Florence, Eccles, Sue, Drysdale, Martin, Workman, Paul
Published in Molecular cancer therapeutics (01.04.2007)
Published in Molecular cancer therapeutics (01.04.2007)
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Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing
Reader, John C, Matthews, Thomas P, Klair, Suki, Cheung, Kwai-Ming J, Scanlon, Jane, Proisy, Nicolas, Addison, Glynn, Ellard, John, Piton, Nelly, Taylor, Suzanne, Cherry, Michael, Fisher, Martin, Boxall, Kathy, Burns, Samantha, Walton, Michael I, Westwood, Isaac M, Hayes, Angela, Eve, Paul, Valenti, Melanie, de Haven Brandon, Alexis, Box, Gary, van Montfort, Rob L. M, Williams, David H, Aherne, G. Wynne, Raynaud, Florence I, Eccles, Suzanne A, Garrett, Michelle D, Collins, Ian
Published in Journal of medicinal chemistry (22.12.2011)
Published in Journal of medicinal chemistry (22.12.2011)
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In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors
SHARP, Swee Y, BOXALL, Kathy, PATTERSON, Lisa, MATTHEWS, Thomas P, CHEUNG, Kwai-Ming J, BALL, Karen, HAYES, Angela, RAYNAUD, Florence, MARAIS, Richard, PEARL, Laurence, ECCLES, Sue, AHERNE, Wynne, ROWLANDS, Martin, MCDONALD, Edward, WORKMAN, Paul, PRODROMOU, Chrisostomos, ROE, S. Mark, MALONEY, Alison, POWERS, Marissa, CLARKE, Paul A, BOX, Gary, SANDERSON, Sharon
Published in Cancer research (Chicago, Ill.) (01.03.2007)
Published in Cancer research (Chicago, Ill.) (01.03.2007)
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Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors
Wilson, Stuart C., Atrash, Butrus, Barlow, Clare, Eccles, Susan, Fischer, Peter M., Hayes, Angela, Kelland, Lloyd, Jackson, Wayne, Jarman, Michael, Mirza, Amin, Moreno, Javier, Nutley, Bernard P., Raynaud, Florence I., Sheldrake, Peter, Walton, Mike, Westwood, Robert, Whittaker, Steven, Workman, Paul, McDonald, Edward
Published in Bioorganic & medicinal chemistry (15.11.2011)
Published in Bioorganic & medicinal chemistry (15.11.2011)
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Globorotalia truncatulinoides in the Mediterranean Basin during the Middle–Late Holocene: Bio-Chronological and Oceanographic Indicator
Margaritelli, Giulia, Lirer, Fabrizio, Schroeder, Katrin, Cloke-Hayes, Angela, Caruso, Antonio, Capotondi, Lucilla, Broggy, Teresa, Cacho, Isabel, Sierro, Francisco J.
Published in Geosciences (Basel) (01.06.2022)
Published in Geosciences (Basel) (01.06.2022)
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Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors
Smith, Nicola F, Hayes, Angela, James, Karen, Nutley, Bernard P, McDonald, Edward, Henley, Alan, Dymock, Brian, Drysdale, Martin J, Raynaud, Florence I, Workman, Paul
Published in Molecular cancer therapeutics (01.06.2006)
Published in Molecular cancer therapeutics (01.06.2006)
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Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse
Nutley, Bernard P, Raynaud, Florence I, Wilson, Stuart C, Fischer, Peter M, Hayes, Angela, Goddard, Phyllis M, McClue, Steven J, Jarman, Michael, Lane, David P, Workman, Paul
Published in Molecular cancer therapeutics (01.01.2005)
Published in Molecular cancer therapeutics (01.01.2005)
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