Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids
Southam, Andrew D, Khanim, Farhat L, Hayden, Rachel E, Constantinou, Julia K, Koczula, Katarzyna M, Michell, Robert H, Viant, Mark R, Drayson, Mark T, Bunce, Chris M
Published in Cancer research (Chicago, Ill.) (15.06.2015)
Published in Cancer research (Chicago, Ill.) (15.06.2015)
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Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia
Khanim, Farhat L, Hayden, Rachel E, Birtwistle, Jane, Lodi, Alessia, Tiziani, Stefano, Davies, Nicholas J, Ride, Jon P, Viant, Mark R, Gunther, Ulrich L, Mountford, Joanne C, Schrewe, Heinrich, Green, Richard M, Murray, Jim A, Drayson, Mark T, Bunce, Chris M
Published in PloS one (07.12.2009)
Published in PloS one (07.12.2009)
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Nm23-H1 Indirectly Promotes the Survival of Acute Myeloid Leukemia Blast Cells by Binding to More Mature Components of the Leukemic Clone
LILLY, Andrew J, KHANIM, Farhat L, HAYDEN, Rachel E, LUONG, Quang T, DRAYSON, Mark T, BUNCE, Christopher M
Published in Cancer research (Chicago, Ill.) (01.02.2011)
Published in Cancer research (Chicago, Ill.) (01.02.2011)
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Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrate- and medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance
HAYDEN, Rachel E, PRATT, Guy, DRAYSON, Mark T, BUNCE, Chris M
Published in Haematologica (Roma) (01.11.2010)
Published in Haematologica (Roma) (01.11.2010)
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AKR1C Isoforms Represent a Novel Cellular Target for Jasmonates alongside Their Mitochondrial-Mediated Effects
DAVIES, Nicholas J, HAYDEN, Rachel E, SIMPSON, Paul J, BIRTWISTLE, Jane, MAYER, Katarina, RIDE, Jonathan P, BUNCE, Chris M
Published in Cancer research (Chicago, Ill.) (01.06.2009)
Published in Cancer research (Chicago, Ill.) (01.06.2009)
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Bezafibrate and medroxyprogesterone acetate target resting and CD40L-stimulated primary marginal zone lymphoma and show promise in indolent B-cell non-Hodgkin lymphomas
Hayden, Rachel E., Kussaibati, Racha, Cronin, Laura M., Pratt, Guy, Roberts, Claudia, Drayson, Mark T., Bunce, Christopher M.
Published in Leukemia & lymphoma (01.04.2015)
Published in Leukemia & lymphoma (01.04.2015)
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Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML)
Murray, Jim A., Khanim, Farhat L., Hayden, Rachel E., Craddock, Charlie F., Holyoake, Tessa L., Jackson, Nick, Lumley, Matthew, Bunce, Chris M., Drayson, Mark T.
Published in British journal of haematology (01.04.2010)
Published in British journal of haematology (01.04.2010)
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The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs
DESMOND, Julian C, MOUNTFORD, Joanne C, DRAYSON, Mark T, WALKER, Elizabeth A, HEWISON, Martin, RIDE, Jonathan P, LUONG, Quang T, HAYDEN, Rachel E, VANIN, Elio F, BUNCE, Christopher M
Published in Cancer research (Chicago, Ill.) (15.01.2003)
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Published in Cancer research (Chicago, Ill.) (15.01.2003)
Journal Article
Elevated FOSB‐expression; a potential marker of valproate sensitivity in AML
Khanim, Farhat L., Bradbury, Charlotte A., Arrazi, Julie, Hayden, Rachel E., Rye, Adam, Basu, Supratik, MacWhannell, Alan, Sawers, Alistair, Griffiths, Michael, Cook, Mark, Freeman, Sylvie, Nightingale, Karl P., Grimwade, David, Falciani, Francesco, Turner, Bryan M., Bunce, Chris M., Craddock, Charles
Published in British journal of haematology (01.02.2009)
Published in British journal of haematology (01.02.2009)
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Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy
Pearce, Claire, Hayden, Rachel E, Bunce, Christopher M, Khanim, Farhat L
Published in BMC cell biology (28.04.2009)
Published in BMC cell biology (28.04.2009)
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The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis
Birtwistle, Jane, Hayden, Rachel E, Khanim, Farhat L, Green, Richard M, Pearce, Claire, Davies, Nicholas J, Wake, Naomi, Schrewe, Heiner, Ride, Jonathan P, Chipman, James K, Bunce, Chris M
Published in Mutation research (09.03.2009)
Published in Mutation research (09.03.2009)
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All-trans retinoic acid increases transgene expression in MSCV-transduced cells, via a mechanism that is retinoid receptor dependent but independent of cellular differentiation
Mountford, Joanne C, Vanin, Elio F, Hayden, Rachel E, Bunce, Christopher M
Published in Human gene therapy (01.01.2005)
Published in Human gene therapy (01.01.2005)
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Supramolecular Iron Cylinder with Unprecedented DNA Binding Is a Potent Cytostatic and Apoptotic Agent without Exhibiting Genotoxicity
Hotze, Anna C.G., Hodges, Nikolas J., Hayden, Rachel E., Sanchez-Cano, Carlos, Paines, Christopher, Male, Natalia, Tse, Man-Kit, Bunce, Chris M., Chipman, J. Kevin, Hannon, Michael J.
Published in Chemistry & biology (22.12.2008)
Published in Chemistry & biology (22.12.2008)
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Journal Article
Characterisation of Histone Deacetylase (HDAC) Expression Profiles in Acute Myeloid Leukaemia: A Basis for the Development of Targeted Therapy Using Histone Deacetylase Inhibitors
Bradbury, Charlotte A., Khanim, Farhat L., Mehta, Priyanka, Hayden, Rachel E., Craddock, Charles F., Bunce, Chris M., Turner, Bryan M.
Published in Blood (16.11.2004)
Published in Blood (16.11.2004)
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