Discovery of Novel Chemotypes to a G-Protein-Coupled Receptor through Ligand-Steered Homology Modeling and Structure-Based Virtual Screening
Cavasotto, Claudio N, Orry, Andrew J. W, Murgolo, Nicholas J, Czarniecki, Michael F, Kocsi, Sue Ann, Hawes, Brian E, O’Neill, Kim A, Hine, Heather, Burton, Marybeth S, Voigt, Johannes H, Abagyan, Ruben A, Bayne, Marvin L, Monsma, Frederick J
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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The Melanin-Concentrating Hormone Receptor Couples to Multiple G Proteins to Activate Diverse Intracellular Signaling Pathways
Hawes, Brian E, Kil, Erin, Green, Beverly, O’Neill, Kim, Fried, Steve, Graziano, Michael P
Published in Endocrinology (Philadelphia) (01.12.2000)
Published in Endocrinology (Philadelphia) (01.12.2000)
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In Vivo Responsiveness to Ezetimibe Correlates with Niemann-Pick C1 Like-1 (NPC1L1) Binding Affinity: Comparison of Multiple Species NPC1L1 Orthologs
Hawes, Brian E, O'neill, Kim A, Yao, Xiaorui, Crona, James H, Davis, Jr, Harry R, Graziano, Michael P, Altmann, Scott W
Published in Molecular pharmacology (01.01.2007)
Published in Molecular pharmacology (01.01.2007)
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The Target of Ezetimibe Is Niemann-Pick C1-Like 1 (NPC1L1)
Garcia-Calvo, Margarita, Lisnock, JeanMarie, Bull, Herbert G., Hawes, Brian E., Burnett, Duane A., Braun, Matthew P., Crona, James H., Davis, Harry R., Dean, Dennis C., Detmers, Patricia A., Graziano, Michael P., Hughes, Meredith, MacIntyre, D. Euan, Ogawa, Anthony, O'Neill, Kim A., Sai Prasad N. Iyer, Shevell, Diane E., Smith, Marsha M., Tang, Yui S., Makarewicz, Amanda M., Ujjainwalla, Feroze, Altmann, Scott W., Chapman, Kevin T., Thornberry, Nancy A., Goldstein, Joseph L.
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.2005)
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Differential Intracellular Signaling of the GalR1 and GalR2 Galanin Receptor Subtypes
Wang, Suke, Hashemi, Tanaz, Fried, Steven, Clemmons, Anthony L, Hawes, Brian E
Published in Biochemistry (Easton) (12.05.1998)
Published in Biochemistry (Easton) (12.05.1998)
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Mitogenic signaling via G protein-coupled receptors
VAN BIESEN, T, LUTTRELL, L. M, HAWES, B. E, LEFKOWITZ, R. J
Published in Endocrine reviews (01.12.1996)
Published in Endocrine reviews (01.12.1996)
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Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas
McBriar, Mark D, Guzik, Henry, Shapiro, Sherry, Paruchova, Jaroslava, Xu, Ruo, Palani, Anandan, Clader, John W, Cox, Kathleen, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian D, Weig, Blair, Weston, Daniel J, Farley, Constance, Cook, John
Published in Journal of medicinal chemistry (06.04.2006)
Published in Journal of medicinal chemistry (06.04.2006)
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Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
Blesen, Tim van, Hawes, Brian E, Luttrell, Deirdre K, Krueger, Kathleen M, Touhara, Kazushige, Porfflri, Emilio, Sakaue, Motoyoshi, Luttrell, Louis M, Lefkowitz, Robert J
Published in Nature (London) (31.08.1995)
Published in Nature (London) (31.08.1995)
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Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists: Orally Efficacious Antiobesity Therapeutics
McBriar, Mark D, Guzik, Henry, Xu, Ruo, Paruchova, Jaroslava, Li, Shengjian, Palani, Anandan, Clader, John W, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian, Weig, Blair
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
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Identification and Pharmacological Characterization of a Novel Human Melanin-concentrating Hormone Receptor, MCH-R2
Wang, Suke, Behan, Jiang, O'Neill, Kim, Weig, Blair, Fried, Steven, Laz, Thomas, Bayne, Marvin, Gustafson, Eric, Hawes, Brian E.
Published in The Journal of biological chemistry (14.09.2001)
Published in The Journal of biological chemistry (14.09.2001)
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The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo
Kemp, E Helen, Waterman, Elizabeth A, Hawes, Brian E, O'Neill, Kim, Gottumukkala, Raju V S R K, Gawkrodger, David J, Weetman, Anthony P, Watson, Philip F
Published in The Journal of clinical investigation (01.04.2002)
Published in The Journal of clinical investigation (01.04.2002)
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Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice
Kowalski, Timothy J., Spar, Brian D., Weig, Blair, Farley, Constance, Cook, John, Ghibaudi, Lorraine, Fried, Steve, O'Neill, Kim, Del Vecchio, Robert A., McBriar, Mark, Guzik, Henry, Clader, John, Hawes, Brian E., Hwa, Joyce
Published in European journal of pharmacology (27.03.2006)
Published in European journal of pharmacology (27.03.2006)
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Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases
Sasikumar, T.K., Qiang, Li, Burnett, Duane A., Greenlee, William J., Hawes, Brian E., Kowalski, Timothy J., O’Neill, Kim, Spar, Brian D., Weig, Blair
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Cellular actions of nociceptin: transduction mechanisms
Hawes, Brian E., Graziano, Michael P., Lambert, David G.
Published in Peptides (New York, N.Y. : 1980) (01.07.2000)
Published in Peptides (New York, N.Y. : 1980) (01.07.2000)
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Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists
Xu, Ruo, Li, Shengjian, Paruchova, Jaroslava, McBriar, Mark D., Guzik, Henry, Palani, Anandan, Clader, John W., Cox, Kathleen, Greenlee, William J., Hawes, Brian E., Kowalski, Timothy J., O’Neill, Kim, Spar, Brian D., Weig, Blair, Weston, Daniel J.
Published in Bioorganic & medicinal chemistry (15.05.2006)
Published in Bioorganic & medicinal chemistry (15.05.2006)
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Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists
Wu, Wen-Lian, Burnett, Duane A., Caplen, Mary Ann, Domalski, Martin S., Bennett, Chad, Greenlee, William J., Hawes, Brian E., O’Neill, Kim, Weig, Blair, Weston, Daniel, Spar, Brian, Kowalski, Timothy
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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