High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs
Akhtari, Farida S, Green, Adrian J, Small, George W, Havener, Tammy M, House, John S, Roell, Kyle R, Reif, David M, McLeod, Howard L, Wiltshire, Timothy, Motsinger-Reif, Alison A
Published in PLoS genetics (26.08.2021)
Published in PLoS genetics (26.08.2021)
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Journal Article
Synergistic drug combinations and machine learning for drug repurposing in chordoma
Anderson, Edward, Havener, Tammy M., Zorn, Kimberley M., Foil, Daniel H., Lane, Thomas R., Capuzzi, Stephen J., Morris, Dave, Hickey, Anthony J., Drewry, David H., Ekins, Sean
Published in Scientific reports (31.07.2020)
Published in Scientific reports (31.07.2020)
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Journal Article
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma
Asquith, Christopher R. M, Naegeli, Kaleb M, East, Michael P, Laitinen, Tuomo, Havener, Tammy M, Wells, Carrow I, Johnson, Gary L, Drewry, David H, Zuercher, William J, Morris, David C
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore
Ong, Han Wee, Truong, Anna, Kwarcinski, Frank, de Silva, Chandi, Avalani, Krisha, Havener, Tammy M., Chirgwin, Michael, Galal, Kareem A., Willis, Caleb, Krämer, Andreas, Liu, Shubin, Knapp, Stefan, Derbyshire, Emily R., Zutshi, Reena, Drewry, David H.
Published in European journal of medicinal chemistry (05.03.2023)
Published in European journal of medicinal chemistry (05.03.2023)
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Journal Article
Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro
Galal, Kareem A., Truong, Anna, Kwarcinski, Frank, de Silva, Chandi, Avalani, Krisha, Havener, Tammy M., Chirgwin, Michael E., Merten, Eric, Ong, Han Wee, Willis, Caleb, Abdelwaly, Ahmad, Helal, Mohamed A., Derbyshire, Emily R., Zutshi, Reena, Drewry, David H.
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Journal Article
Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2
Ong, Han Wee, Yang, Xuan, Smith, Jeffery L, Taft-Benz, Sharon, Howell, Stefanie, Dickmander, Rebekah J, Havener, Tammy M, Sanders, Marcia K, Brown, Jason W, Couñago, Rafael M, Chang, Edcon, Krämer, Andreas, Moorman, Nathaniel J, Heise, Mark, Axtman, Alison D, Drewry, David H, Willson, Timothy M
Published in Molecules (Basel, Switzerland) (02.09.2024)
Published in Molecules (Basel, Switzerland) (02.09.2024)
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Journal Article
Multiple approaches to repurposing drugs for neuroblastoma
Rank, Laura, Puhl, Ana C., Havener, Tammy M., Anderson, Edward, Foil, Daniel H., Zorn, Kimberley M., Monakhova, Natalia, Riabova, Olga, Hickey, Anthony J., Makarov, Vadim, Ekins, Sean
Published in Bioorganic & medicinal chemistry (01.11.2022)
Published in Bioorganic & medicinal chemistry (01.11.2022)
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Journal Article
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5‑a]pyrimidine Host CSNK2 Inhibitors for Combatting β‑Coronavirus Replication
Ong, Han Wee, Yang, Xuan, Smith, Jeffery L., Dickmander, Rebekah J., Brown, Jason W., Havener, Tammy M., Taft-Benz, Sharon, Howell, Stefanie, Sanders, Marcia K., Capener, Jacob L., Couñago, Rafael M., Chang, Edcon, Krämer, Andreas, Moorman, Nathaniel J., Heise, Mark, Axtman, Alison D., Drewry, David H., Willson, Timothy M.
Published in Journal of medicinal chemistry (25.07.2024)
Published in Journal of medicinal chemistry (25.07.2024)
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Journal Article
Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes
Rotroff, Daniel M, Yee, Sook Wah, Zhou, Kaixin, Marvel, Skylar W, Shah, Hetal S, Jack, John R, Havener, Tammy M, Hedderson, Monique M, Kubo, Michiaki, Herman, Mark A, Gao, He, Mychaleckyi, Josyf C, McLeod, Howard L, Doria, Alessandro, Giacomini, Kathleen M, Pearson, Ewan R, Wagner, Michael J, Buse, John B, Motsinger-Reif, Alison A
Published in Diabetes (New York, N.Y.) (01.07.2018)
Published in Diabetes (New York, N.Y.) (01.07.2018)
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Journal Article
Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes
Rotroff, Daniel M, Pijut, Sonja S, Marvel, Skylar W, Jack, John R, Havener, Tammy M, Pujol, Aurora, Schluter, Agatha, Graf, Gregory A, Ginsberg, Henry N, Shah, Hetal S, Gao, He, Morieri, Mario-Luca, Doria, Alessandro, Mychaleckyi, Josyf C, McLeod, Howard L, Buse, John B, Wagner, Michael J, Motsinger-Reif, Alison A
Published in Clinical pharmacology and therapeutics (01.04.2018)
Published in Clinical pharmacology and therapeutics (01.04.2018)
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Journal Article
Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization
Romano, Lisa E L, Aw, Wen Yih, Hixson, Kathryn M, Novoselova, Tatiana V, Havener, Tammy M, Howell, Stefanie, Taylor-Blake, Bonnie, Hall, Charlotte L, Xing, Lei, Beri, Josh, Nethisinghe, Suran, Perna, Laura, Hatimy, Abubakar, Altadonna, Ginevra Chioccioli, Graves, Lee M, Herring, Laura E, Hickey, Anthony J, Thalassinos, Konstantinos, Chapple, J Paul, Wolter, Justin M
Published in Cell reports (Cambridge) (01.11.2022)
Published in Cell reports (Cambridge) (01.11.2022)
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Journal Article
Race and smoking status associated with paclitaxel drug response in patient-derived lymphoblastoid cell lines
Akhtari, Farida S, Havener, Tammy M, Hertz, Daniel L, Ash, Jeremy, Larson, Alexandra, Carey, Lisa A, McLeod, Howard L, Motsinger-Reif, Alison A
Published in Pharmacogenetics and genomics (01.02.2021)
Published in Pharmacogenetics and genomics (01.02.2021)
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Journal Article
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2
Davis-Gilbert, Zachary W., Krämer, Andreas, Dunford, James E., Howell, Stefanie, Senbabaoglu, Filiz, Wells, Carrow I., Bashore, Frances M., Havener, Tammy M., Smith, Jeffery L., Hossain, Mohammad A., Oppermann, Udo, Drewry, David H., Axtman, Alison D.
Published in ACS medicinal chemistry letters (13.04.2023)
Published in ACS medicinal chemistry letters (13.04.2023)
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Journal Article
MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients
Gonzalez, Ricardo D, Small, George W, Green, Adrian J, Akhtari, Farida S, Motsinger-Reif, Alison A, Quintanilha, Julia C F, Havener, Tammy M, Reif, David M, McLeod, Howard L, Wiltshire, Tim
Published in Pharmaceuticals (Basel, Switzerland) (17.05.2023)
Published in Pharmaceuticals (Basel, Switzerland) (17.05.2023)
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Journal Article
RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients
Gonzalez, Ricardo D, Small, George W, Green, Adrian J, Akhtari, Farida S, Havener, Tammy M, Quintanilha, Julia C F, Cipriani, Amber B, Reif, David M, McLeod, Howard L, Motsinger-Reif, Alison A, Wiltshire, Tim
Published in Pharmaceuticals (Basel, Switzerland) (10.05.2023)
Published in Pharmaceuticals (Basel, Switzerland) (10.05.2023)
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Journal Article
Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy
Small, George W, Akhtari, Farida S, Green, Adrian J, Havener, Tammy M, Sikes, Michael, Quintanhila, Julia, Gonzalez, Ricardo D, Reif, David M, Motsinger-Reif, Alison A, McLeod, Howard L, Wiltshire, Tim
Published in Cells (Basel, Switzerland) (01.06.2023)
Published in Cells (Basel, Switzerland) (01.06.2023)
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Journal Article
Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines
Brown, Chad C, Havener, Tammy M, Medina, Marisa W, Jack, John R, Krauss, Ronald M, McLeod, Howard L, Motsinger-Reif, Alison A
Published in Pharmacogenomics (01.02.2014)
Published in Pharmacogenomics (01.02.2014)
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Journal Article
Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees
Watson, Venita Gresham, Motsinger-Reif, Alison, Hardison, Nicholas E, Peters, Eric J, Havener, Tammy M, Everitt, Lorraine, Auman, James Todd, Comins, Daniel L, McLeod, Howard L
Published in PloS one (05.05.2011)
Published in PloS one (05.05.2011)
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