Identification of the Missing Component in the Mitochondrial Benzamidoxime Prodrug-converting System as a Novel Molybdenum Enzyme
Havemeyer, Antje, Bittner, Florian, Wollers, Silke, Mendel, Ralf, Kunze, Thomas, Clement, Bernd
Published in The Journal of biological chemistry (17.11.2006)
Published in The Journal of biological chemistry (17.11.2006)
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The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice
Jakobs, Heyka H, Mikula, Michal, Havemeyer, Antje, Strzalkowska, Adriana, Borowa-Chmielak, Monika, Dzwonek, Artur, Gajewska, Marta, Hennig, Ewa E, Ostrowski, Jerzy, Clement, Bernd
Published in PloS one (21.08.2014)
Published in PloS one (21.08.2014)
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HEPATIC, EXTRAHEPATIC, MICROSOMAL, AND MITOCHONDRIAL ACTIVATION OF THE N-HYDROXYLATED PRODRUGS BENZAMIDOXIME, GUANOXABENZ, AND RO 48-3656 ([[1-[(2S)-2-[[4-[(HYDROXYAMINO)IMINOMETHYL]BENZOYL]AMINO]-1-OXOPROPYL]-4-PIPERIDINYL]OXY]-ACETIC ACID)
CLEMENT, Bernd, MAU, Sabine, DETERS, Stephanie, HAVEMEYER, Antje
Published in Drug metabolism and disposition (01.11.2005)
Published in Drug metabolism and disposition (01.11.2005)
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Journal Article
The mammalian molybdenum enzymes of mARC
Ott, Gudrun, Havemeyer, Antje, Clement, Bernd
Published in Journal of biological inorganic chemistry (01.03.2015)
Published in Journal of biological inorganic chemistry (01.03.2015)
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Journal Article
Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes
Kubitza, Christian, Bittner, Florian, Ginsel, Carsten, Havemeyer, Antje, Clement, Bernd, Scheidig, Axel J.
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2018)
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Mitochondrial amidoxime-reducing component 2 (MARC2) has a significant role in N-reductive activity and energy metabolism
Rixen, Sophia, Havemeyer, Antje, Tyl-Bielicka, Anita, Pysniak, Kazimiera, Gajewska, Marta, Kulecka, Maria, Ostrowski, Jerzy, Mikula, Michal, Clement, Bernd
Published in The Journal of biological chemistry (15.11.2019)
Published in The Journal of biological chemistry (15.11.2019)
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Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)
Kotthaus, Jürke, Wahl, Bettina, Havemeyer, Antje, Kotthaus, Joscha, Schade, Dennis, Garbe-Schönberg, Dieter, Mendel, Ralf, Bittner, Florian, Clement, Bernd
Published in Biochemical journal (15.01.2011)
Published in Biochemical journal (15.01.2011)
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Journal Article
The Involvement of the Mitochondrial Amidoxime Reducing Component (mARC) in the Reductive Metabolism of Hydroxamic Acids
Ginsel, Carsten, Plitzko, Birte, Froriep, Danilo, Stolfa, Diana A, Jung, Manfred, Kubitza, Christian, Scheidig, Axel J, Havemeyer, Antje, Clement, Bernd
Published in Drug metabolism and disposition (01.10.2018)
Published in Drug metabolism and disposition (01.10.2018)
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Journal Article
Biochemical and Spectroscopic Characterization of the Human Mitochondrial Amidoxime Reducing Components hmARC-1 and hmARC-2 Suggests the Existence of a New Molybdenum Enzyme Family in Eukaryotes
Wahl, Bettina, Reichmann, Debora, Niks, Dimitri, Krompholz, Nina, Havemeyer, Antje, Clement, Bernd, Messerschmidt, Tania, Rothkegel, Martin, Biester, Harald, Hille, Russ, Mendel, Ralf R., Bittner, Florian
Published in The Journal of biological chemistry (26.11.2010)
Published in The Journal of biological chemistry (26.11.2010)
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Journal Article
Human mitochondrial amidoxime reducing component (mARC): An electrochemical method for identifying new substrates and inhibitors
Kalimuthu, Palraj, Havemeyer, Antje, Clement, Bernd, Kubitza, Christian, Scheidig, Axel J., Bernhardt, Paul V.
Published in Electrochemistry communications (01.11.2017)
Published in Electrochemistry communications (01.11.2017)
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Discovery of N-(4-Aminobutyl)-N '-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dirnethylarginine Dinnethylaminohydrolase-1 (hDDAH-1)
Lunk, Ina, Litty, Felix-Alexander, Hennig, Sven, Vetter, Ingrid R., Kotthaus, Juerke, Altmann, Karin S., Ott, Gudrun, Havemeyer, Antje, Garcia, Carmen Carrillo, Clement, Bernd, Schade, Dennis
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Journal Article
The Pivotal Role of the Mitochondrial Amidoxime Reducing Component 2 in Protecting Human Cells against Apoptotic Effects of the Base Analog N6-Hydroxylaminopurine
Plitzko, Birte, Havemeyer, Antje, Kunze, Thomas, Clement, Bernd
Published in The Journal of biological chemistry (17.04.2015)
Published in The Journal of biological chemistry (17.04.2015)
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Journal Article
Reduction of Sulfamethoxazole Hydroxylamine (SMX-HA) by the Mitochondrial Amidoxime Reducing Component (mARC)
Ott, Gudrun, Plitzko, Birte, Krischkowski, Carmen, Reichmann, Debora, Bittner, Florian, Mendel, Ralf R, Kunze, Thomas, Clement, Bernd, Havemeyer, Antje
Published in Chemical research in toxicology (20.10.2014)
Published in Chemical research in toxicology (20.10.2014)
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The Mitochondrial Amidoxime Reducing Component (mARC) Is Involved in Detoxification of N‑Hydroxylated Base Analogues
Krompholz, Nina, Krischkowski, Carmen, Reichmann, Debora, Garbe-Schönberg, Dieter, Mendel, Ralf-R, Bittner, Florian, Clement, Bernd, Havemeyer, Antje
Published in Chemical research in toxicology (19.11.2012)
Published in Chemical research in toxicology (19.11.2012)
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Journal Article
Discovery of N‑(4-Aminobutyl)‑N′‑(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase‑1 (hDDAH-1)
Lunk, Ina, Litty, Felix-Alexander, Hennig, Sven, Vetter, Ingrid R, Kotthaus, Jürke, Altmann, Karin S, Ott, Gudrun, Havemeyer, Antje, García, Carmen Carrillo, Clement, Bernd, Schade, Dennis
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Journal Article
Defining the Role of the NADH-Cytochrome-b5 Reductase 3 in the Mitochondrial Amidoxime Reducing Component Enzyme System
Plitzko, Birte, Havemeyer, Antje, Bork, Bettina, Bittner, Florian, Mendel, Ralf, Clement, Bernd
Published in Drug metabolism and disposition (01.10.2016)
Published in Drug metabolism and disposition (01.10.2016)
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Journal Article
Activation of the anti-cancer agent upamostat by the mARC enzyme system
Froriep, Danilo, Clement, Bernd, Bittner, Florian, Mendel, Ralf R., Reichmann, Debora, Schmalix, Wolfgang, Havemeyer, Antje
Published in Xenobiotica (01.09.2013)
Published in Xenobiotica (01.09.2013)
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Journal Article
The Mitochondrial Amidoxime Reducing Component (mARC): Involvement in Metabolic Reduction of N-Oxides, Oximes and N-Hydroxyamidinohydrazones
Jakobs, Heyka H., Froriep, Danilo, Havemeyer, Antje, Mendel, Ralf R., Bittner, Florian, Clement, Bernd
Published in ChemMedChem (01.10.2014)
Published in ChemMedChem (01.10.2014)
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