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Transmission of SARS-CoV-2 in Domestic Cats
Halfmann, Peter J, Hatta, Masato, Chiba, Shiho, Maemura, Tadashi, Fan, Shufang, Takeda, Makoto, Kinoshita, Noriko, Hattori, Shin-ichiro, Sakai-Tagawa, Yuko, Iwatsuki-Horimoto, Kiyoko, Imai, Masaki, Kawaoka, Yoshihiro
Published in The New England journal of medicine (06.08.2020)
Published in The New England journal of medicine (06.08.2020)
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A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Hayashi, Hironori, Allu, Srinivasa Rao, Raghavaiah, Jakka, Bulut, Haydar, Das, Debananda, Anson, Brandon J., Lendy, Emma K., Takamatsu, Yuki, Takamune, Nobutoki, Kishimoto, Naoki, Murayama, Kazutaka, Hasegawa, Kazuya, Li, Mi, Davis, David A., Kodama, Eiichi N., Yarchoan, Robert, Wlodawer, Alexander, Misumi, Shogo, Mesecar, Andrew D., Ghosh, Arun K., Mitsuya, Hiroaki
Published in Nature communications (28.01.2021)
Published in Nature communications (28.01.2021)
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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development
Imai, Masaki, Iwatsuki-Horimoto, Kiyoko, Hatta, Masato, Loeber, Samantha, Halfmann, Peter J., Nakajima, Noriko, Watanabe, Tokiko, Ujie, Michiko, Takahashi, Kenta, Ito, Mutsumi, Yamada, Shinya, Fan, Shufang, Chiba, Shiho, Kuroda, Makoto, Guan, Lizheng, Takada, Kosuke, Armbrust, Tammy, Balogh, Aaron, Furusawa, Yuri, Okuda, Moe, Ueki, Hiroshi, Yasuhara, Atsuhiro, Sakai-Tagawa, Yuko, Lopes, Tiago J. S., Kiso, Maki, Yamayoshi, Seiya, Kinoshita, Noriko, Ohmagari, Norio, Hattori, Shin-ichiro, Takeda, Makoto, Mitsuya, Hiroaki, Krammer, Florian, Suzuki, Tadaki, Kawaoka, Yoshihiro
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2020)
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Indole Chloropyridinyl Ester-Derived SARS-CoV‑2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X‑ray Structural Studies
Ghosh, Arun K, Raghavaiah, Jakka, Shahabi, Dana, Yadav, Monika, Anson, Brandon J, Lendy, Emma K, Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Mitsuya, Hiroaki, Mesecar, Andrew D
Published in Journal of Medicinal Chemistry (14.10.2021)
Published in Journal of Medicinal Chemistry (14.10.2021)
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Tecovirimat is active against various MPXV strains, while cidofovir, brincidofovir, trifluridine, and gemcitabine have no detectable MPXV-specific antiviral activity
Higashi-Kuwata, Nobuyo, Kato, Mariko, Hattori, Shin-ichiro, Takamatsu, Yuki, Mitsuya, Hiroaki
Published in Virus research (01.10.2025)
Published in Virus research (01.10.2025)
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Comparison of Rapid Antigen Tests for COVID-19
Yamayoshi, Seiya, Sakai-Tagawa, Yuko, Koga, Michiko, Akasaka, Osamu, Nakachi, Ichiro, Koh, Hidefumi, Maeda, Kenji, Adachi, Eisuke, Saito, Makoto, Nagai, Hiroyuki, Ikeuchi, Kazuhiko, Ogura, Takayuki, Baba, Rie, Fujita, Kensuke, Fukui, Takahiro, Ito, Fumimaro, Hattori, Shin-ichiro, Yamamoto, Kei, Nakamoto, Takato, Furusawa, Yuri, Yasuhara, Atsuhiro, Ujie, Michiko, Yamada, Shinya, Ito, Mutsumi, Mitsuya, Hiroaki, Omagari, Norio, Yotsuyanagi, Hiroshi, Iwatsuki-Horimoto, Kiyoko, Imai, Masaki, Kawaoka, Yoshihiro
Published in Viruses (10.12.2020)
Published in Viruses (10.12.2020)
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Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasma
Maeda, Kenji, Higashi-Kuwata, Nobuyo, Kinoshita, Noriko, Kutsuna, Satoshi, Tsuchiya, Kiyoto, Hattori, Shin-ichiro, Matsuda, Kouki, Takamatsu, Yuki, Gatanaga, Hiroyuki, Oka, Shinichi, Sugiyama, Haruhito, Ohmagari, Norio, Mitsuya, Hiroaki
Published in Scientific reports (10.03.2021)
Published in Scientific reports (10.03.2021)
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Structure–Activity Relationship Studies of SARS-CoV‑2 Main Protease Inhibitors Containing 4‑Fluorobenzothiazole-2-carbonyl Moieties
Tsuji, Kohei, Ishii, Takahiro, Kobayakawa, Takuya, Higashi-Kuwata, Nobuyo, Shinohara, Kouki, Azuma, Chika, Miura, Yutaro, Nakano, Hiroki, Wada, Naoya, Hattori, Shin-ichiro, Bulut, Haydar, Mitsuya, Hiroaki, Tamamura, Hirokazu
Published in Journal of medicinal chemistry (12.10.2023)
Published in Journal of medicinal chemistry (12.10.2023)
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Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations
Yasutake, Yoshiaki, Hattori, Shin-ichiro, Kumamoto, Hiroki, Tamura, Noriko, Maeda, Kenji, Mitsuya, Hiroaki
Published in Scientific Reports (08.07.2024)
Published in Scientific Reports (08.07.2024)
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SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads
Ghosh, Arun K., Shahabi, Dana, Imhoff, Mackenzie E.C., Kovela, Satish, Sharma, Ashish, Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Mitsuya, Hiroaki, Mesecar, Andrew D.
Published in Bioorganic & Medicinal Chemistry Letters (15.11.2023)
Published in Bioorganic & Medicinal Chemistry Letters (15.11.2023)
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GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection
Hattori, Shin-ichiro, Higshi-Kuwata, Nobuyo, Raghavaiah, Jakka, Das, Debananda, Bulut, Haydar, Davis, David A., Takamatsu, Yuki, Matsuda, Kouki, Takamune, Nobutoki, Kishimoto, Naoki, Okamura, Tadashi, Misumi, Shogo, Yarchoan, Robert, Maeda, Kenji, Ghosh, Arun K., Mitsuya, Hiroaki
Published in mBio (20.08.2020)
Published in mBio (20.08.2020)
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Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement
Tsuji, Kohei, Kobayakawa, Takuya, Ishii, Takahiro, Higashi-Kuwata, Nobuyo, Azuma, Chika, Shinohara, Kouki, Miura, Yutaro, Yamamoto, Kenichi, Nishimura, Soshi, Hattori, Shin-ichiro, Bulut, Haydar, Mitsuya, Hiroaki, Tamamura, Hirokazu
Published in Chemical & pharmaceutical bulletin (01.12.2023)
Published in Chemical & pharmaceutical bulletin (01.12.2023)
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Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine
Yasutake, Yoshiaki, Hattori, Shin-ichiro, Tamura, Noriko, Matsuda, Kouki, Kohgo, Satoru, Maeda, Kenji, Mitsuya, Hiroaki
Published in Scientific reports (20.02.2020)
Published in Scientific reports (20.02.2020)
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Antibody titers against SARS-CoV-2 decline, but do not disappear for several months
Yamayoshi, Seiya, Yasuhara, Atsuhiro, Ito, Mutsumi, Akasaka, Osamu, Nakamura, Morio, Nakachi, Ichiro, Koga, Michiko, Mitamura, Keiko, Yagi, Kazuma, Maeda, Kenji, Kato, Hideaki, Nojima, Masanori, Pattinson, David, Ogura, Takayuki, Baba, Rie, Fujita, Kensuke, Nagai, Hiroyuki, Yamamoto, Shinya, Saito, Makoto, Adachi, Eisuke, Ochi, Junichi, Hattori, Shin-ichiro, Suzuki, Tetsuya, Miyazato, Yusuke, Chiba, Shiho, Okuda, Moe, Murakami, Jurika, Hamabata, Taiki, Iwatsuki-Horimoto, Kiyoko, Nakajima, Hideaki, Mitsuya, Hiroaki, Omagari, Norio, Sugaya, Norio, Yotsuyanagi, Hiroshi, Kawaoka, Yoshihiro
Published in EClinicalMedicine (01.02.2021)
Published in EClinicalMedicine (01.02.2021)
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Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C–induced HIV latency reversal
Matsuda, Kouki, Kobayakawa, Takuya, Tsuchiya, Kiyoto, Hattori, Shin-ichiro, Nomura, Wataru, Gatanaga, Hiroyuki, Yoshimura, Kazuhisa, Oka, Shinichi, Endo, Yasuyuki, Tamamura, Hirokazu, Mitsuya, Hiroaki, Maeda, Kenji
Published in The Journal of biological chemistry (04.01.2019)
Published in The Journal of biological chemistry (04.01.2019)
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Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV
Higashi-Kuwata, Nobuyo, Hayashi, Sanae, Kumamoto, Hiroki, Ogata-Aoki, Hiromi, Das, Debananda, Venzon, David, Hattori, Shin-ichiro, Bulut, Haydar, Hashimoto, Mai, Otagiri, Masaki, Takamune, Nobutoki, Kishimoto, Naoki, Davis, David A., Misumi, Shogo, Kakuni, Masakazu, Tanaka, Yasuhito, Mitsuya, Hiroaki
Published in Journal of hepatology (01.05.2021)
Published in Journal of hepatology (01.05.2021)
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Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants
Ghosh, Arun K., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Kovela, Satish, Brindisi, Margherita, Osswald, Heather L., Sekhara Reddy, Bhavanam, Agniswamy, Johnson, Wang, Yuan‐Fang, Aoki, Manabu, Hattori, Shin‐ichiro, Weber, Irene T., Mitsuya, Hiroaki
Published in ChemMedChem (23.04.2018)
Published in ChemMedChem (23.04.2018)
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Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300
Davis, David A., Bulut, Haydar, Shrestha, Prabha, Yaparla, Amulya, Jaeger, Hannah K., Hattori, Shin-ichiro, Wingfield, Paul T., Mieyal, John J., Mitsuya, Hiroaki, Yarchoan, Robert
Published in mBio (31.08.2021)
Published in mBio (31.08.2021)
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Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity
Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki
Published in Scientific reports (30.06.2020)
Published in Scientific reports (30.06.2020)
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Design and Synthesis of Potent HIV‑1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X‑ray Structural Studies
Ghosh, Arun K, Williams, Jacqueline N, Ho, Rachel Y, Simpson, Hannah M, Hattori, Shin-ichiro, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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