Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma
Hatlen, Megan A, Schmidt-Kittler, Oleg, Sherwin, Cori Ann, Rozsahegyi, Emily, Rubin, Nooreen, Sheets, Michael P, Kim, Joseph L, Miduturu, Chandrasekhar, Bifulco, Neil, Brooijmans, Natasja, Shi, Hongliang, Guzi, Timothy, Boral, Andy, Lengauer, Christoph, Dorsch, Marion, Kim, Richard D, Kang, Yoon-Koo, Wolf, Beni B, Hoeflich, Klaus P
Published in Cancer discovery (01.12.2019)
Published in Cancer discovery (01.12.2019)
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Journal Article
The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation
Wang, Lan, Gural, Alexander, Sun, Xiao-Jian, Zhao, Xinyang, Perna, Fabiana, Huang, Gang, Hatlen, Megan A., Vu, Ly, Liu, Fan, Xu, Haiming, Asai, Takashi, Xu, Hao, Deblasio, Tony, Menendez, Silvia, Voza, Francesca, Jiang, Yanwen, Cole, Philip A., Zhang, Jinsong, Melnick, Ari, Roeder, Robert G., Nimer, Stephen D.
Published in Science (American Association for the Advancement of Science) (05.08.2011)
Published in Science (American Association for the Advancement of Science) (05.08.2011)
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Journal Article
Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia
Shih, Alan H., Jiang, Yanwen, Meydan, Cem, Shank, Kaitlyn, Pandey, Suveg, Barreyro, Laura, Antony-Debre, Ileana, Viale, Agnes, Socci, Nicholas, Sun, Yongming, Robertson, Alexander, Cavatore, Magali, de Stanchina, Elisa, Hricik, Todd, Rapaport, Franck, Woods, Brittany, Wei, Chen, Hatlen, Megan, Baljevic, Muhamed, Nimer, Stephen D., Tallman, Martin, Paietta, Elisabeth, Cimmino, Luisa, Aifantis, Iannis, Steidl, Ulrich, Mason, Chris, Melnick, Ari, Levine, Ross L.
Published in Cancer cell (13.04.2015)
Published in Cancer cell (13.04.2015)
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Journal Article
JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation
Liu, Fan, Zhao, Xinyang, Perna, Fabiana, Wang, Lan, Koppikar, Priya, Abdel-Wahab, Omar, Harr, Michael W., Levine, Ross L., Xu, Hao, Tefferi, Ayalew, Deblasio, Anthony, Hatlen, Megan, Menendez, Silvia, Nimer, Stephen D.
Published in Cancer cell (15.02.2011)
Published in Cancer cell (15.02.2011)
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Journal Article
Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles
Hatlen, Megan A, Arora, Kanika, Vacic, Vladimir, Grabowska, Ewa A, Liao, Willey, Riley-Gillis, Bridget, Oschwald, Dayna M, Wang, Lan, Joergens, Jacob E, Shih, Alan H, Rapaport, Franck, Gu, Shengqing, Voza, Francesca, Asai, Takashi, Neel, Benjamin G, Kharas, Michael G, Gonen, Mithat, Levine, Ross L, Nimer, Stephen D
Published in The Journal of experimental medicine (11.01.2016)
Published in The Journal of experimental medicine (11.01.2016)
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Journal Article
Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms
Asai, Takashi, Hatlen, Megan A., Lossos, Chen, Ndiaye-Lobry, Delphine, Deblasio, Anthony, Murata, Kazunori, Fleisher, Martin, Cortizas, Elena M., Verdun, Ramiro E., Petrini, John, Nimer, Stephen D.
Published in Scientific reports (10.03.2016)
Published in Scientific reports (10.03.2016)
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Journal Article
Post-translational modifications of Runx1 regulate its activity in the cell
Wang, Lan, Huang, Gang, Zhao, Xinyang, Hatlen, Megan A., Vu, Ly, Liu, Fan, Nimer, Stephen D.
Published in Blood cells, molecules, & diseases (01.07.2009)
Published in Blood cells, molecules, & diseases (01.07.2009)
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Journal Article
BLU-808, a Potent and Selective Small Molecule Inhibitor of Wild-type c-KIT for Mast Cell Disorders
Grassian, Alexandra, Haidle, Andrew, AuDuong, Sophia, Baker, James, Du, Guangyan, Hatlen, Megan, Hiki, Melissa, Hu, Wei, Keane, Kevin, Mudiyanselage, Thiwanka Samarakoon, Perola, Emanuele, Pien, Christine, Sawant, Priyanka, Wilson, Doug, Meissner, Rob, Brubaker, Jason, Ribich, Scott, Kim, Joe
Published in Journal of allergy and clinical immunology (01.02.2024)
Published in Journal of allergy and clinical immunology (01.02.2024)
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Journal Article
Abstract 1279: Development of a selective CDK2-E inhibitor in CCNE driven cancers
Choi, Yoon J., Wenglowsky, Steve, Brown, Victoria, Bifulco, Neil, Choi, Yeon S., Guo, Jian, Hatlen, Megan, Kim, Joseph, LaBranche, Tim, Lobbardi, Riadh, Perola, Emanuele, Rozsahegyi, Emily, Maynard, Michelle, Ramsden, Phil, Silva, Grace, Stevison, Faith, Vargas, Richard, Wang, Ruduan, Wilson, Doug, Woessner, Rich, Zhang, Dean, Meissner, Rob, Hoeflich, Klaus, Dorsch, Marion
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression
Wang, Lan, Man, Na, Sun, Xiao-Jian, Tan, Yurong, García-Cao, Marta, Liu, Fan, Hatlen, Megan, Xu, Haiming, Huang, Gang, Mattlin, Meredith, Mehta, Arpit, Rampersaud, Evadnie, Benezra, Robert, Nimer, Stephen D.
Published in Blood (30.07.2015)
Published in Blood (30.07.2015)
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Journal Article
Abstract A118: Identification of resistance mechanisms to FGFR4 targeted therapy in hepatocellular carcinoma
Hatlen, Megan A, Schmidt-Kittler, Oleg, Sherwin, Cori-Ann, Rozsahegyi, Emily, Rubin, Nooreen, Sheets, Michael, Kim, Joseph L, Miduturu, Chandra, Bifulco, Neil, Brooijmans, Natasja, Shi, Hongliang, Guzi, Timothy, Boral, Andy, Lengauer, Christoph, Dorsch, Marion, Kim, Richard D, Kang, Yoon-Koo, Wolf, Beni B, Hoeflich, Klaus P
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Differential role of Id1 in MLL-AF9–driven leukemia based on cell of origin
Man, Na, Sun, Xiao-Jian, Tan, Yurong, García-Cao, Marta, Liu, Fan, Cheng, Guoyan, Hatlen, Megan, Xu, Haiming, Shah, Ronit, Chastain, Nolan, Liu, Na, Huang, Gang, Zhou, Yuan, Sheng, Mengyao, Song, Junhong, Yang, Feng-Chun, Benezra, Robert, Nimer, Stephen D., Wang, Lan
Published in Blood (12.05.2016)
Published in Blood (12.05.2016)
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Journal Article
Prmt5 Negatively Regulates Erythropoiesis By Multiple Mechanisms, Including Controlling DNA Methyltransferase 3A Protein Levels
Hamard, Pierre-Jacques, Luciani, Luisa, Liu, Fan, Cheng, Guoyan, Hatlen, Megan A., Guryanova, Olga A, Zhao, Xinyang, Levine, Ross L., Nimer, Stephen D.
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
JAK2 V617F, PRMT5, and GATA-1 Form a Regulatory Loop That Controls Autophagy Via Effects on ATG3 Gene Expression
Harr, Michael W, Zhao, Xinyang, Klein, Mary, Liu, Fan, Hatlen, Megan, Nimer, Stephen
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Journal Article
Integrative Analysis of the Mutational Landscape of Mouse and Human AML Identifies Functionally Relevant Leukemia Disease Alleles
Hatlen, Megan A., Arora, Kanika, Vacic, Vladimir, Grabowska, Ewa A., Liao, Willey, Riley-Gillis, Bridget, Oschwald, Dayna M., Wang, Lan, Joergens, Jacob E., Shih, Alan H., Rapaport, Franck, Gu, Shengqing, Voza, Francesca, Asai, Takashi, Neel, Benjamin, Kharas, Michael G., Gonen, Mithat, Levine, Ross L., Nimer, Stephen D.
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
JAK2V617F-Mediated Phosphorylation of PRMT5 Down-Regulates Its Methyltransferase Activity and Promotes Myeloproliferation
Liu, Fan, Zhao, Xinyang, Perna, Fabiana, Wang, Lan, Koppikar, Priya, Abdel-Wahab, Omar, Levine, Ross L, Xue, Hao, Hatlen, Megan, Menendez, Silvia, Nimer, Stephen D
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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Journal Article
JAK2V617F-mediated phosphorylation of PRMT5 down-regulates its methyltransferase activity and promotes myeloproliferation
Liu, Fan, Zhao, Xinyang, Perna, Fabiana, Wang, Lan, Koppikar, Priya, Abdel-Wahab, Omar, Harr, Michael W., Levine, Ross L., Xu, Hao, Tefferi, Ayalew, Deblasio, Anthony, Hatlen, Megan, Menendez, Silvia, Nimer, Stephen D.
Published in Cancer cell (15.02.2011)
Published in Cancer cell (15.02.2011)
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Journal Article
The Acetylation of AML1-ETO Is Required for Leukemogenesis
Wang, Lan, Gural, Alexander, Perna, Fabiana, Sun, Xiaojian, Zhao, Xinyang, Xu, Haiming, Hatlen, Megan A, Huang, Gang, Liu, Fan, Xu, Hao, Deblasio, Tony, Menendez, Silvia, Voza, Francesca, Roeder, Robert, Nimer, Stephen
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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Journal Article
The Leukemogenicity of AML1-ET0 Is Dependent on Site-Specific Lysine Acetylation
LAN WANG, GURAL, Alexander, ASAI, Takashi, HAO XU, DEBLASIO, Tony, MENENDEZ, Silvia, VOZA, Francesca, YANWEN JIANG, COLE, Philip A, JINSONG ZHANG, MELNICK, Ari, ROEDER, Robert G, SUN, Xiao-Jian, NIMER, Stephen D, XINYANG ZHAO, PERNA, Fabiana, GANG HUANG, HATLEN, Megan A, LY VU, FAN LIU, HAIMING XU
Published in Science (American Association for the Advancement of Science) (2011)
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Published in Science (American Association for the Advancement of Science) (2011)
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