Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB)
Arikawa, Yasuyoshi, Nishida, Haruyuki, Kurasawa, Osamu, Hasuoka, Atsushi, Hirase, Keizo, Inatomi, Nobuhiro, Hori, Yasunobu, Matsukawa, Jun, Imanishi, Akio, Kondo, Mitsuyo, Tarui, Naoki, Hamada, Teruki, Takagi, Terufumi, Takeuchi, Toshiyuki, Kajino, Masahiro
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
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Evolution of a Synthetic Strategy: Total Synthesis of (±)-Welwitindolinone A Isonitrile
Reisman, Sarah E, Ready, Joseph M, Weiss, Matthew M, Hasuoka, Atsushi, Hirata, Makoto, Tamaki, Kazuhiko, Ovaska, Timo V, Smith, Catherine J, Wood, John L
Published in Journal of the American Chemical Society (13.02.2008)
Published in Journal of the American Chemical Society (13.02.2008)
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Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate
Aikawa, Katsuji, Asano, Moriteru, Ono, Koji, Habuka, Noriyuki, Yano, Jason, Wilson, Keith, Fujita, Hisashi, Kandori, Hitoshi, Hara, Takahito, Morimoto, Megumi, Santou, Takashi, Yamaoka, Masuo, Nakayama, Masaharu, Hasuoka, Atsushi
Published in Bioorganic & medicinal chemistry (01.07.2017)
Published in Bioorganic & medicinal chemistry (01.07.2017)
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Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers
Nishida, Haruyuki, Hasuoka, Atsushi, Arikawa, Yasuyoshi, Kurasawa, Osamu, Hirase, Keizo, Inatomi, Nobuhiro, Hori, Yasunobu, Sato, Fumihiko, Tarui, Naoki, Imanishi, Akio, Kondo, Mitsuyo, Takagi, Terufumi, Kajino, Masahiro
Published in Bioorganic & medicinal chemistry (15.06.2012)
Published in Bioorganic & medicinal chemistry (15.06.2012)
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Journal Article
Total Synthesis of (±)-Welwitindolinone A Isonitrile
Reisman, Sarah E, Ready, Joseph M, Hasuoka, Atsushi, Smith, Catherine J, Wood, John L
Published in Journal of the American Chemical Society (08.02.2006)
Published in Journal of the American Chemical Society (08.02.2006)
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Molecular Modeling, Design, Synthesis, and Biological Activity of 1H-Pyrrolo[2,3-c]pyridine-7-amine Derivatives as Potassium-Competitive Acid Blockers
Arikawa, Yasuyoshi, Hasuoka, Atsushi, Hirase, Keizo, Inatomi, Nobuhiro, Sato, Fumihiko, Hori, Yasunobu, Takagi, Terufumi, Tarui, Naoki, Kawamoto, Makiko, Kajino, Masahiro
Published in Chemical & pharmaceutical bulletin (2014)
Published in Chemical & pharmaceutical bulletin (2014)
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Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists
Yamamoto, Satoshi, Tomita, Naoki, Suzuki, Yuri, Suzaki, Tomohiko, Kaku, Tomohiro, Hara, Takahito, Yamaoka, Masuo, Kanzaki, Naoyuki, Hasuoka, Atsushi, Baba, Atsuo, Ito, Mitsuhiro
Published in Bioorganic & medicinal chemistry (01.04.2012)
Published in Bioorganic & medicinal chemistry (01.04.2012)
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High-throughput screening of potassium-competitive acid blockers
Kondo, Mitsuyo, Kawamoto, Makiko, Hasuoka, Atsushi, Kajino, Masahiro, Inatomi, Nobuhiro, Tarui, Naoki
Published in Journal of biomolecular screening (01.02.2012)
Published in Journal of biomolecular screening (01.02.2012)
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Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs)
Arikawa, Yasuyoshi, Hasuoka, Atsushi, Nishida, Haruyuki, Hirase, Keizo, Inatomi, Nobuhiro, Takagi, Terufumi, Tarui, Naoki, Kawamoto, Makiko, Imanishi, Akio, Itoh, Fumio, Kajino, Masahiro
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
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Syntheses, Crystal and Solution Structures, Ligand-Exchange, and Ligand-Coupling Reactions of Mixed Pentaarylantimony Compounds
Schröder, Günter, Okinaka, Takaaki, Mimura, Yasuyuki, Watanabe, Mitsuko, Matsuzaki, Takayuki, Hasuoka, Atsushi, Yamamoto, Yohsuke, Matsukawa, Shiro, Akiba, Kin-ya
Published in Chemistry : a European journal (01.01.2007)
Published in Chemistry : a European journal (01.01.2007)
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Synthesis and biological evaluation of novel selective androgen receptor modulators (SARM-s) Part Ill: Discovery of 4-(5-oxopyrrolidine-1-yl) benzonitrile derivative 2f as a clinical candidate
Aikawa, Katsuji, Asano, Moriteru, Ono, Koji, Habuka, Noriyuki, Yano, Jason, Wilson, Keith, Fujita, Hisashi, Kandori, Hitoshi, Hara, Takahito, Morimoto, Megumi, Santou, Takashi, Yamaoka, Masuo, Nakayama, Masaharu, Hasuoka, Atsushi
Published in Bioorganic & medicinal chemistry (01.07.2017)
Published in Bioorganic & medicinal chemistry (01.07.2017)
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Synthesis and Anti-Helicobacter pylori Activity of Pyloricidin Derivatives: I. Structure-activity Relationships on the Terminal Peptidic Moiety
HASUOKA, ATSUSHI, NISHIKIMI, YUJI, NAKAYAMA, YUTAKA, KAMIYAMA, KEIJI, NAKAO, MASAFUMI, MIYAGAWA, KEN-ICHIRO, NISHIMURA, OSAMU, FUJINO, MASAHIKO
Published in Journal of antibiotics (01.03.2002)
Published in Journal of antibiotics (01.03.2002)
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Total Synthesis of Novel Antibiotics Pyloricidin A, B and C and Their Application in the Study of Pyloricidin Derivatives
HASUOKA, ATSUSHI, NISHIKIMI, YUJI, NAKAYAMA, YUTAKA, KAMIYAMA, KEIJI, NAKAO, MASAFUMI, MIYAGAWA, KEN-ICHIRO, NISHIMURA, OSAMU, FUJINO, MASAHIKO
Published in Journal of antibiotics (01.02.2002)
Published in Journal of antibiotics (01.02.2002)
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