Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Axten, Jeffrey M, Medina, Jesús R, Feng, Yanhong, Shu, Arthur, Romeril, Stuart P, Grant, Seth W, Li, William Hoi Hong, Heerding, Dirk A, Minthorn, Elisabeth, Mencken, Thomas, Atkins, Charity, Liu, Qi, Rabindran, Sridhar, Kumar, Rakesh, Hong, Xuan, Goetz, Aaron, Stanley, Thomas, Taylor, J. David, Sigethy, Scott D, Tomberlin, Ginger H, Hassell, Annie M, Kahler, Kirsten M, Shewchuk, Lisa M, Gampe, Robert T
Published in Journal of medicinal chemistry (23.08.2012)
Published in Journal of medicinal chemistry (23.08.2012)
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Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development
Axten, Jeffrey M, Romeril, Stuart P, Shu, Arthur, Ralph, Jeffrey, Medina, Jesús R, Feng, Yanhong, Li, William Hoi Hong, Grant, Seth W, Heerding, Dirk A, Minthorn, Elisabeth, Mencken, Thomas, Gaul, Nathan, Goetz, Aaron, Stanley, Thomas, Hassell, Annie M, Gampe, Robert T, Atkins, Charity, Kumar, Rakesh
Published in ACS medicinal chemistry letters (10.10.2013)
Published in ACS medicinal chemistry letters (10.10.2013)
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Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases
Bezerra, Gustavo Arruda, Dobrovetsky, Elena, Dong, Aiping, Seitova, Almagul, Crombett, Lissete, Shewchuk, Lisa M, Hassell, Annie M, Sweitzer, Sharon M, Sweitzer, Thomas D, McDevitt, Patrick J, Johanson, Kyung O, Kennedy-Wilson, Karen M, Cossar, Doug, Bochkarev, Alexey, Gruber, Karl, Dhe-Paganon, Sirano
Published in PloS one (29.08.2012)
Published in PloS one (29.08.2012)
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The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway
Baker, Keith D., Shewchuk, Lisa M., Kozlova, Tatiana, Makishima, Makoto, Hassell, Annie, Wisely, Bruce, Caravella, Justin A., Lambert, Millard H., Reinking, Jeffrey L., Krause, Henry, Thummel, Carl S., Willson, Timothy M., Mangelsdorf, David J.
Published in Cell (13.06.2003)
Published in Cell (13.06.2003)
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Exploration of the P1 SAR of aldehyde cathepsin K inhibitors
CATALANO, John G, DEATON, David N, FURFINE, Eric S, HASSELL, Annie M, MCFADYEN, Robert B, MILLER, Aaron B, MILLER, Larry R, SHEWCHUK, Lisa M, WILLARD, Derril H, WRIGHT, Lois L
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
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Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP)
Haffner, Curt D., Diaz, Caroline J., Miller, Aaron B., Reid, Robert A., Madauss, Kevin P., Hassell, Annie, Hanlon, Mary H., Porter, David J.T., Becherer, J. David, Carter, Luke H.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1 H -indol-5-yl)-7 H -pyrrolo[2,3- d ]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Axten, Jeffrey M., Medina, Jesús R., Feng, Yanhong, Shu, Arthur, Romeril, Stuart P., Grant, Seth W., Li, William Hoi Hong, Heerding, Dirk A., Minthorn, Elisabeth, Mencken, Thomas, Atkins, Charity, Liu, Qi, Rabindran, Sridhar, Kumar, Rakesh, Hong, Xuan, Goetz, Aaron, Stanley, Thomas, Taylor, J. David, Sigethy, Scott D., Tomberlin, Ginger H., Hassell, Annie M., Kahler, Kirsten M., Shewchuk, Lisa M., Gampe, Robert T.
Published in Journal of medicinal chemistry (23.08.2012)
Published in Journal of medicinal chemistry (23.08.2012)
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Journal Article
Exploration of the P 1 SAR of aldehyde cathepsin K inhibitors
Catalano, John G., Deaton, David N., Furfine, Eric S., Hassell, Annie M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Shewchuk, Lisa M., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (2004)
Published in Bioorganic & medicinal chemistry letters (2004)
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Ready, teddy, go - the first look at Brum's big bears
Published in Birmingham post (Birmingham, England)
(29.12.2016)
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