The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro‑2H‑pyran-4-yl)-1,3-dihydro‑2H‑imidazo[4,5‑c]quinolin-2-one)
Pike, Kurt G, Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, de-Almeida, Camila, Degorce, Sebastien L, Didelot, Myriam, Dishington, Allan, Ducray, Richard, Durant, Stephen T, Hassall, Lorraine A, Holmes, Jane, Hughes, Gareth D, MacFaul, Philip A, Mulholland, Keith R, McGuire, Thomas M, Ouvry, Gilles, Pass, Martin, Robb, Graeme, Stratton, Natalie, Wang, Zhenhua, Wilson, Joanne, Zhai, Baochang, Zhao, Kang, Al-Huniti, Nidal
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
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Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase
Degorce, Sébastien L, Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C, Hassall, Lorraine A, Lach, Franck, Lau, Alan, McGuire, Thomas M, Nowak, Thorsten, Ouvry, Gilles, Pike, Kurt G, Thomason, Andrew G
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Synthesis and kinetic resolution of N-Boc-2-arylpiperidines
Cochrane, Edward J., Leonori, Daniele, Hassall, Lorraine A., Coldham, Iain
Published in Chemical communications (Cambridge, England) (07.09.2014)
Published in Chemical communications (Cambridge, England) (07.09.2014)
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Preparation of 1‑Substituted Tetrahydro-β-carbolines by Lithiation–Substitution
Cochrane, Edward J, Hassall, Lorraine A, Coldham, Iain
Published in Journal of organic chemistry (05.06.2015)
Published in Journal of organic chemistry (05.06.2015)
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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)
Pike, Kurt G, Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, de-Almeida, Camila, Degorce, Sebastien L, Didelot, Myriam, Dishington, Allan, Ducray, Richard, Durant, Stephen T, Hassall, Lorraine A, Holmes, Jane, Hughes, Gareth D, MacFaul, Philip A, Mulholland, Keith R, McGuire, Thomas M, Ouvry, Gilles, Pass, Martin, Robb, Graeme, Stratton, Natalie, Wang, Zhenhua, Wilson, Joanne, Zhai, Baochang, Zhao, Kang, Al-Huniti, Nidal
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
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Journal Article
Discovery of a Series of 3‑Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors
Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Colclough, Nicola, Dishington, Allan, Durant, Stephen, Goldberg, Kristin, Hassall, Lorraine A, Hughes, Gareth D, MacFaul, Philip A, McGuire, Thomas M, Pass, Martin, Patel, Anil, Pearson, Stuart, Petersen, Jens, Pike, Kurt G, Robb, Graeme, Stratton, Natalie, Xin, Guohong, Zhai, Baochang
Published in ACS medicinal chemistry letters (09.08.2018)
Published in ACS medicinal chemistry letters (09.08.2018)
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Correction to Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase
Degorce, Sébastien L, Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C, Hassall, Lorraine A, Lach, Franck, Lau, Alan, McGuire, Thomas M, Nowak, Thorsten, Ouvry, Gilles, Pike, Kurt G, Thomason, Andrew G
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet
Chio, Freda K., Warne, Julie, Gough, Damien, Penny, Mark, Green (née Martinović), Sasa, Coles, Simon J., Hursthouse, Mike B., Jones, Peter, Hassall, Lorraine, McGuire, Thomas M., Dobbs, Adrian P.
Published in Tetrahedron (08.07.2011)
Published in Tetrahedron (08.07.2011)
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Synthesis of Novel Hydroxymethyl-Substituted Fused Heterocycles
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Published in Synthesis (Stuttgart) (18.02.2016)
Published in Synthesis (Stuttgart) (18.02.2016)
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Expedient synthesis of biologically important sulfonylmethyl pyrimidines
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Published in Tetrahedron letters (16.07.2014)
Published in Tetrahedron letters (16.07.2014)
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Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor
Finlay, M. Raymond V, Anderton, Mark, Ashton, Susan, Ballard, Peter, Bethel, Paul A, Box, Matthew R, Bradbury, Robert H, Brown, Simon J, Butterworth, Sam, Campbell, Andrew, Chorley, Christopher, Colclough, Nicola, Cross, Darren A. E, Currie, Gordon S, Grist, Matthew, Hassall, Lorraine, Hill, George B, James, Daniel, James, Michael, Kemmitt, Paul, Klinowska, Teresa, Lamont, Gillian, Lamont, Scott G, Martin, Nathaniel, McFarland, Heather L, Mellor, Martine J, Orme, Jonathon P, Perkins, David, Perkins, Paula, Richmond, Graham, Smith, Peter, Ward, Richard A, Waring, Michael J, Whittaker, David, Wells, Stuart, Wrigley, Gail L
Published in Journal of medicinal chemistry (23.10.2014)
Published in Journal of medicinal chemistry (23.10.2014)
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Discovery of 4‑{4-[(3R)‑3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}‑1H‑indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity
Foote, Kevin M, Blades, Kevin, Cronin, Anna, Fillery, Shaun, Guichard, Sylvie S, Hassall, Lorraine, Hickson, Ian, Jacq, Xavier, Jewsbury, Philip J, McGuire, Thomas M, Nissink, J. Willem M, Odedra, Rajesh, Page, Ken, Perkins, Paula, Suleman, Abid, Tam, Kin, Thommes, Pia, Broadhurst, Rebecca, Wood, Christine
Published in Journal of medicinal chemistry (14.03.2013)
Published in Journal of medicinal chemistry (14.03.2013)
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Barlaam, Bernard, De Savi, Chris, Dishington, Allan, Drew, Lisa, Ferguson, Andrew D, Ferguson, Douglas, Gu, Chungang, Hande, Sudhir, Hassall, Lorraine, Hawkins, Janet, Hird, Alexander W, Holmes, Jane, Lamb, Michelle L, Lister, Andrew S, McGuire, Thomas M, Moore, Jane E, O’Connell, Nichole, Patel, Anil, Pike, Kurt G, Sarkar, Ujjal, Shao, Wenlin, Stead, Darren, Varnes, Jeffrey G, Vasbinder, Melissa M, Wang, Lei, Wu, Liangwei, Xue, Lin, Yang, Bin, Yao, Tieguang
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
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Synthesis and kinetic resolution of N-Boc-2-arylpiperidinesElectronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI: 10.1039/c4cc04576a
Cochrane, Edward J, Leonori, Daniele, Hassall, Lorraine A, Coldham, Iain
Year of Publication 31.07.2014
Year of Publication 31.07.2014
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ChemInform Abstract: Expedient Synthesis of Biologically Important Sulfonylmethyl Pyrimidines
Blades, Kevin, Demeritt, Julie, Fillery, Shaun, Foote, Kevin M., Greenwood, Ryan, Gregson, Clare, Hassall, Lorraine A., McGuire, Thomas M., Pike, Kurt G., Williams, Emma
Published in ChemInform (29.12.2014)
Published in ChemInform (29.12.2014)
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Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo
Luke, Richard W.A., Ballard, Peter, Buttar, David, Campbell, Leonie, Curwen, Jon, Emery, Steve C., Griffen, Alison M., Hassall, Lorraine, Hayter, Barry R., Jones, Cliff D., McCoull, William, Mellor, Martine, Swain, Mike L., Tucker, Julie A.
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-Aminoaryl Pyridine Derivatives
Morgentin, Rémy, Barlaam, Bernard, Foote, Kevin, Hassall, Lorraine, Hawkins, Janet, Jones, Clifford D., Le Griffon, Antoine, Peru, Aurelien, Plé, Patrick
Published in Synthetic communications (01.01.2012)
Published in Synthetic communications (01.01.2012)
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