Hypoxia and acidosis: immune suppressors and therapeutic targets
Damgaci, Sultan, Ibrahim‐Hashim, Arig, Enriquez‐Navas, Pedro M., Pilon‐Thomas, Shari, Guvenis, Albert, Gillies, Robert J.
Published in Immunology (01.07.2018)
Published in Immunology (01.07.2018)
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Journal Article
Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
ROBEY, Ian F, BAGGETT, Brenda K, GILLIES, Robert J, KIRKPATRICK, Nathaniel D, ROE, Denise J, DOSESCU, Julie, SLOANE, Bonnie F, IBRAHIM HASHIM, Arig, MORSE, David L, RAGHUNAND, Natarajan, GATENBY, Robert A
Published in Cancer research (Chicago, Ill.) (15.03.2009)
Published in Cancer research (Chicago, Ill.) (15.03.2009)
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Journal Article
Reduction of metastasis using a non-volatile buffer
Ibrahim Hashim, Arig, Cornnell, Heather H., Coelho Ribeiro, Maria de Lourdes, Abrahams, Dominique, Cunningham, Jessica, Lloyd, Mark, Martinez, Gary V., Gatenby, Robert A., Gillies, Robert J.
Published in Clinical & experimental metastasis (01.12.2011)
Published in Clinical & experimental metastasis (01.12.2011)
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Journal Article
Cancer‐associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF‐κB activation
Avnet, Sofia, Di Pompo, Gemma, Chano, Tokuhiro, Errani, Costantino, Ibrahim‐Hashim, Arig, Gillies, Robert J., Donati, Davide Maria, Baldini, Nicola
Published in International journal of cancer (15.03.2017)
Published in International journal of cancer (15.03.2017)
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Journal Article
Acidity Generated by the Tumor Microenvironment Drives Local Invasion
ESTRELLA, Veronica, TINGAN CHEN, JOHNSON, Joseph, GATENBY, Robert A, GILLIES, Robert J, LLOYD, Mark, WOJTKOWIAK, Jonathan, CORNNELL, Heather H, IBRAHIM-HASHIM, Arig, BAILEY, Kate, BALAGURUNATHAN, Yoganand, ROTHBERG, Jennifer M, SLOANE, Bonnie F
Published in Cancer research (Chicago, Ill.) (01.03.2013)
Published in Cancer research (Chicago, Ill.) (01.03.2013)
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Journal Article
Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
Pilon-Thomas, Shari, Kodumudi, Krithika N, El-Kenawi, Asmaa E, Russell, Shonagh, Weber, Amy M, Luddy, Kimberly, Damaghi, Mehdi, Wojtkowiak, Jonathan W, Mulé, James J, Ibrahim-Hashim, Arig, Gillies, Robert J
Published in Cancer research (Chicago, Ill.) (15.03.2016)
Published in Cancer research (Chicago, Ill.) (15.03.2016)
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Journal Article
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Walton, Zandra E., Patel, Chirag H., Brooks, Rebekah C., Yu, Yongjun, Ibrahim-Hashim, Arig, Riddle, Malini, Porcu, Alessandra, Jiang, Tianying, Ecker, Brett L., Tameire, Feven, Koumenis, Constantinos, Weeraratna, Ashani T., Welsh, David K., Gillies, Robert, Alwine, James C., Zhang, Lin, Powell, Jonathan D., Dang, Chi V.
Published in Cell (28.06.2018)
Published in Cell (28.06.2018)
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Journal Article
T-cells produce acidic niches in lymph nodes to suppress their own effector functions
Wu, Hao, Estrella, Veronica, Beatty, Matthew, Abrahams, Dominique, El-Kenawi, Asmaa, Russell, Shonagh, Ibrahim-Hashim, Arig, Longo, Dario Livio, Reshetnyak, Yana K., Moshnikova, Anna, Andreev, Oleg A., Luddy, Kimberly, Damaghi, Mehdi, Kodumudi, Krithika, Pillai, Smitha R., Enriquez-Navas, Pedro, Pilon-Thomas, Shari, Swietach, Pawel, Gillies, Robert J.
Published in Nature communications (17.08.2020)
Published in Nature communications (17.08.2020)
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Journal Article
Back to basic: Trials and tribulations of alkalizing agents in cancer
Gillies, Robert J., Ibrahim-Hashim, Arig, Ordway, Bryce, Gatenby, Robert A.
Published in Frontiers in oncology (14.11.2022)
Published in Frontiers in oncology (14.11.2022)
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Journal Article
Frequency-dependent interactions determine outcome of competition between two breast cancer cell lines
Freischel, Audrey R., Damaghi, Mehdi, Cunningham, Jessica J., Ibrahim-Hashim, Arig, Gillies, Robert J., Gatenby, Robert A., Brown, Joel S.
Published in Scientific reports (01.03.2021)
Published in Scientific reports (01.03.2021)
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Journal Article
Imaging pH and metastasis
Hashim, Arig Ibrahim, Zhang, Xiaomeng, Wojtkowiak, Jonathan W., Martinez, Gary V., Gillies, Robert J.
Published in NMR in biomedicine (01.07.2011)
Published in NMR in biomedicine (01.07.2011)
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Journal Article
Immunomodulatory and pro-oncologic effects of ketamine and isoflurane anesthetics in a murine model
Abrahams, Dominique, Ibrahim-Hashim, Arig, Ackerman, Robert S, Brown, Joel S, Whelan, Christopher J, Garfinkel, Megan B, Gatenby, Robert A, Muncey, Aaron R
Published in PloS one (10.10.2023)
Published in PloS one (10.10.2023)
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Journal Article
Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance
Verduzco, Daniel, Lloyd, Mark, Xu, Liping, Ibrahim-Hashim, Arig, Balagurunathan, Yoganand, Gatenby, Robert A, Gillies, Robert J
Published in PloS one (26.03.2015)
Published in PloS one (26.03.2015)
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Journal Article
Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice
Ibrahim-Hashim, Arig, Cornnell, Heather H, Abrahams, Dominique, Lloyd, Mark, Bui, Marilyn, Gillies, Robert J, Gatenby, Robert A
Published in The Journal of urology (01.08.2012)
Published in The Journal of urology (01.08.2012)
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Journal Article
Targeting the Metabolic Microenvironment of Tumors
Bailey, Kate M., Wojtkowiak, Jonathan W., Hashim, Arig Ibrahim, Gillies, Robert J.
Published in Advances in Pharmacology (2012)
Published in Advances in Pharmacology (2012)
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Book Chapter
Journal Article
Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer
Bailey, Kate M, Cornnell, Heather H, Ibrahim-Hashim, Arig, Wojtkowiak, Jonathan W, Hart, Charles P, Zhang, Xiaomeng, Leos, Rafael, Martinez, Gary V, Baker, Amanda F, Gillies, Robert J
Published in PloS one (22.12.2014)
Published in PloS one (22.12.2014)
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Journal Article
Mechanisms of buffer therapy resistance
Bailey, Kate M, Wojtkowiak, Jonathan W, Cornnell, Heather H, Ribeiro, Maria C, Balagurunathan, Yoganand, Hashim, Arig Ibrahim, Gillies, Robert J
Published in Neoplasia (New York, N.Y.) (01.04.2014)
Published in Neoplasia (New York, N.Y.) (01.04.2014)
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Journal Article