HEx: A heterologous expression platform for the discovery of fungal natural products
Harvey, Colin J B, Tang, Mancheng, Schlecht, Ulrich, Horecka, Joe, Fischer, Curt R, Lin, Hsiao-Ching, Li, Jian, Naughton, Brian, Cherry, James, Miranda, Molly, Li, Yong Fuga, Chu, Angela M, Hennessy, James R, Vandova, Gergana A, Inglis, Diane, Aiyar, Raeka S, Steinmetz, Lars M, Davis, Ronald W, Medema, Marnix H, Sattely, Elizabeth, Khosla, Chaitan, St Onge, Robert P, Tang, Yi, Hillenmeyer, Maureen E
Published in Science advances (01.04.2018)
Published in Science advances (01.04.2018)
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Journal Article
Precursor Directed Biosynthesis of an Orthogonally Functional Erythromycin Analogue: Selectivity in the Ribosome Macrolide Binding Pocket
Harvey, Colin J. B, Puglisi, Joseph D, Pande, Vijay S, Cane, David E, Khosla, Chaitan
Published in Journal of the American Chemical Society (25.07.2012)
Published in Journal of the American Chemical Society (25.07.2012)
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Journal Article
Turning the world’s DNA into new medicines
Ho, J.J. David, Dunbar, Kyle L., Naughton, Brian, Harvey, Colin J.B.
Published in Trends in biotechnology (Regular ed.) (01.06.2022)
Published in Trends in biotechnology (Regular ed.) (01.06.2022)
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Journal Article
Identification of the Antifungal Metabolite Chaetoglobosin P From Discosia rubi Using a Cryptococcus neoformans Inhibition Assay: Insights Into Mode of Action and Biosynthesis
Perlatti, Bruno, Nichols, Connie B., Lan, Nan, Wiemann, Philipp, Harvey, Colin J. B., Alspaugh, J. Andrew, Bills, Gerald F.
Published in Frontiers in microbiology (28.07.2020)
Published in Frontiers in microbiology (28.07.2020)
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Journal Article
Comprehensive curation and analysis of fungal biosynthetic gene clusters of published natural products
Li, Yong Fuga, Tsai, Kathleen J.S., Harvey, Colin J.B., Li, James Jian, Ary, Beatrice E., Berlew, Erin E., Boehman, Brenna L., Findley, David M., Friant, Alexandra G., Gardner, Christopher A., Gould, Michael P., Ha, Jae H., Lilley, Brenna K., McKinstry, Emily L., Nawal, Saadia, Parry, Robert C., Rothchild, Kristina W., Silbert, Samantha D., Tentilucci, Michael D., Thurston, Alana M., Wai, Rebecca B., Yoon, Yongjin, Aiyar, Raeka S., Medema, Marnix H., Hillenmeyer, Maureen E., Charkoudian, Louise K.
Published in Fungal genetics and biology (01.04.2016)
Published in Fungal genetics and biology (01.04.2016)
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Journal Article
Targeted Genome Mining Reveals the Biosynthetic Gene Clusters of Natural Product CYP51 Inhibitors
Liu, Nicholas, Abramyan, Elizabeth D, Cheng, Wei, Perlatti, Bruno, Harvey, Colin J.B, Bills, Gerald F, Tang, Yi
Published in Journal of the American Chemical Society (28.04.2021)
Published in Journal of the American Chemical Society (28.04.2021)
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Journal Article
Resistance gene–guided genome mining reveals the roseopurpurins as inhibitors of cyclin-dependent kinases
Dunbar, Kyle L., Perlatti, Bruno, Liu, Nicholas, Cornelius, Amber, Mummau, Daniel, Chiang, Yi-Ming, Hon, Lawrence, Nimavat, Monika, Pallas, Jason, Kordes, Sina, Ng, Ho Leung, Harvey, Colin J. B.
Published in Proceedings of the National Academy of Sciences - PNAS (28.11.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (28.11.2023)
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Journal Article
Improved precursor-directed biosynthesis in E. coli via directed evolution
Lee, Ho Young, Harvey, Colin J B, Cane, David E, Khosla, Chaitan
Published in Journal of antibiotics (01.01.2011)
Published in Journal of antibiotics (01.01.2011)
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Journal Article
Acrophiarin (antibiotic S31794/F‐1) from Penicillium arenicola shares biosynthetic features with both Aspergillus‐ and Leotiomycete‐type echinocandins
Lan, Nan, Perlatti, Bruno, Kvitek, Daniel J., Wiemann, Philipp, Harvey, Colin J. B., Frisvad, Jens, An, Zhiqiang, Bills, Gerald F.
Published in Environmental microbiology (01.06.2020)
Published in Environmental microbiology (01.06.2020)
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Journal Article
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules
Nguyen, Thu P, Fang, Min, Kim, Jiwoong, Wang, Baiyun, Lin, Elisa, Khivansara, Vishal, Barrows, Neha, Rivera-Cancel, Giomar, Goralski, Maria, Cervantes, Christopher L, Xie, Shanhai, Peterson, Johann M, Povedano, Juan Manuel, Antczak, Monika I, Posner, Bruce A, Harvey, Colin J B, Naughton, Brian T, McFadden, David G, Ready, Joseph M, De Brabander, Jef K, Nijhawan, Deepak
Published in Cell chemical biology (16.11.2023)
Published in Cell chemical biology (16.11.2023)
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Journal Article
Anti-cryptococcal activity of preussolides A and B, phosphoethanolamine-substituted 24-membered macrolides, and leptosin C from coprophilous isolates of Preussia typharum
Perlatti, Bruno, Lan, Nan, Xiang, Meichun, Earp, Cody E, Spraker, Joseph E, Harvey, Colin J B, Nichols, Connie B, Alspaugh, J Andrew, Gloer, James B, Bills, Gerald F
Published in Journal of industrial microbiology & biotechnology (23.12.2021)
Published in Journal of industrial microbiology & biotechnology (23.12.2021)
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Journal Article
Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain
Hang, Leibniz, Tang, Man‐Cheng, Harvey, Colin J. B., Page, Claire G., Li, Jian, Hung, Yiu‐Sun, Liu, Nicholas, Hillenmeyer, Maureen E., Tang, Yi
Published in Angewandte Chemie International Edition (01.08.2017)
Published in Angewandte Chemie International Edition (01.08.2017)
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Journal Article
A biosensor-based approach reveals links between efflux pump expression and cell cycle regulation in pleiotropic drug resistance of yeast
Li, Jian, Kolberg, Kristen, Schlecht, Ulrich, St. Onge, Robert P., Aparicio, Ana Maria, Horecka, Joe, Davis, Ronald W., Hillenmeyer, Maureen E., Harvey, Colin J.B.
Published in The Journal of biological chemistry (25.01.2019)
Published in The Journal of biological chemistry (25.01.2019)
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Journal Article
Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli
Vandova, Gergana A, O'Brien, Robert V, Lowry, Brian, Robbins, Thomas F, Fischer, Curt R, Davis, Ronald W, Khosla, Chaitan, Harvey, Colin JB, Hillenmeyer, Maureen E
Published in Journal of antibiotics (01.07.2017)
Published in Journal of antibiotics (01.07.2017)
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Journal Article
Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain
Hang, Leibniz, Tang, Man‐Cheng, Harvey, Colin J. B., Page, Claire G., Li, Jian, Hung, Yiu‐Sun, Liu, Nicholas, Hillenmeyer, Maureen E., Tang, Yi
Published in Angewandte Chemie (01.08.2017)
Published in Angewandte Chemie (01.08.2017)
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Journal Article