Multivalent Soluble Antigen Arrays Exhibit High Avidity Binding and Modulation of B Cell Receptor-Mediated Signaling to Drive Efficacy against Experimental Autoimmune Encephalomyelitis
Hartwell, Brittany L, Pickens, Chad J, Leon, Martin, Berkland, Cory
Published in Biomacromolecules (12.06.2017)
Published in Biomacromolecules (12.06.2017)
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Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity
Hartwell, Brittany L, Melo, Mariane B, Xiao, Peng, Lemnios, Ashley A, Li, Na, Chang, Jason Y H, Yu, Jingyou, Gebre, Makda S, Chang, Aiquan, Maiorino, Laura, Carter, Crystal, Moyer, Tyson J, Dalvie, Neil C, Rodriguez-Aponte, Sergio A, Rodrigues, Kristen A, Silva, Murillo, Suh, Heikyung, Adams, Josetta, Fontenot, Jane, Love, J Christopher, Barouch, Dan H, Villinger, Francois, Ruprecht, Ruth M, Irvine, Darrell J
Published in Science translational medicine (20.07.2022)
Published in Science translational medicine (20.07.2022)
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Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice
Dalvie, Neil C, Rodriguez-Aponte, Sergio A, Hartwell, Brittany L, Tostanoski, Lisa H, Biedermann, Andrew M, Crowell, Laura E, Kaur, Kawaljit, Kumru, Ozan S, Carter, Lauren, Yu, Jingyou, Chang, Aiquan, McMahan, Katherine, Courant, Thomas, Lebas, Celia, Lemnios, Ashley A, Rodrigues, Kristen A, Silva, Murillo, Johnston, Ryan S, Naranjo, Christopher A, Tracey, Mary Kate, Brady, Joseph R, Whittaker, Charles A, Yun, Dongsoo, Brunette, Natalie, Wang, Jing Yang, Walkey, Carl, Fiala, Brooke, Kar, Swagata, Porto, Maciel, Lok, Megan, Andersen, Hanne, Lewis, Mark G, Love, Kerry R, Camp, Danielle L, Silverman, Judith Maxwell, Kleanthous, Harry, Joshi, Sangeeta B, Volkin, David B, Dubois, Patrice M, Collin, Nicolas, King, Neil P, Barouch, Dan H, Irvine, Darrell J, Love, J Christopher
Published in Proceedings of the National Academy of Sciences - PNAS (21.09.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (21.09.2021)
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Harnessing the potential of the NALT and BALT as targets for immunomodulation using engineering strategies to enhance mucosal uptake
Seefeld, Madison L, Templeton, Erin L, Lehtinen, Justin M, Sinclair, Noah, Yadav, Daman, Hartwell, Brittany L
Published in Frontiers in immunology (02.09.2024)
Published in Frontiers in immunology (02.09.2024)
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Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates
Martin, Jacob T., Hartwell, Brittany L., Kumarapperuma, Sidath C., Melo, Mariane B., Carnathan, Diane G., Cossette, Benjamin J., Adams, Josetta, Gong, Siqi, Zhang, Wei, Tokatlian, Talar, Menis, Sergey, Schiffner, Torben, Franklin, Crystal G., Goins, Beth, Fox, Peter T., Silvestri, Guido, Schief, William R., Ruprecht, Ruth M., Irvine, Darrell J.
Published in Biomaterials (01.08.2021)
Published in Biomaterials (01.08.2021)
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Soluble antigen arrays disarm antigen-specific B cells to promote lasting immune tolerance in experimental autoimmune encephalomyelitis
Hartwell, Brittany L., Pickens, Chad J., Leon, Martin, Northrup, Laura, Christopher, Matthew A., Griffin, J. Daniel, Martinez-Becerra, Francisco, Berkland, Cory
Published in Journal of autoimmunity (01.09.2018)
Published in Journal of autoimmunity (01.09.2018)
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Journal Article
Multivalent Nanomaterials: Learning from Vaccines and Progressing to Antigen-Specific Immunotherapies
Hartwell, Brittany L., Antunez, Lorena, Sullivan, Bradley P., Thati, Sharadvi, Sestak, Joshua O., Berkland, Cory
Published in Journal of pharmaceutical sciences (01.02.2015)
Published in Journal of pharmaceutical sciences (01.02.2015)
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Antigen-Specific Binding of Multivalent Soluble Antigen Arrays Induces Receptor Clustering and Impedes B Cell Receptor Mediated Signaling
Hartwell, Brittany L., Martinez-Becerra, Francisco J., Chen, Jun, Shinogle, Heather, Sarnowski, Michelle, Moore, David S., Berkland, Cory
Published in Biomacromolecules (14.03.2016)
Published in Biomacromolecules (14.03.2016)
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Elucidating Vaccine Trafficking Mechanisms using Multimodal Imaging
Hartwell, Brittany L, Martin, Jacob, Chang, Jason Y H, Kumarapperuma, Sidath C, Ruprecht, Ruth M, Irvine, Darrell J
Published in Microscopy and microanalysis (22.07.2023)
Published in Microscopy and microanalysis (22.07.2023)
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Acute B‑Cell Inhibition by Soluble Antigen Arrays Is Valency-Dependent and Predicts Immunomodulation in Splenocytes
Griffin, J. Daniel, Leon, Martin A, Salash, Jean R, Shao, Michael, Hartwell, Brittany L, Pickens, Chad J, Sestak, Joshua O, Berkland, Cory
Published in Biomacromolecules (13.05.2019)
Published in Biomacromolecules (13.05.2019)
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A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity
Silva, Murillo, Kato, Yu, Melo, Mariane B, Phung, Ivy, Freeman, Brian L, Li, Zhongming, Roh, Kangsan, Van Wijnbergen, Jan W, Watkins, Hannah, Enemuo, Chiamaka A, Hartwell, Brittany L, Chang, Jason Y H, Xiao, Shuhao, Rodrigues, Kristen A, Cirelli, Kimberly M, Li, Na, Haupt, Sonya, Aung, Aereas, Cossette, Benjamin, Abraham, Wuhbet, Kataria, Swati, Bastidas, Raiza, Bhiman, Jinal, Linde, Caitlyn, Bloom, Nathaniel I, Groschel, Bettina, Georgeson, Erik, Phelps, Nicole, Thomas, Ayush, Bals, Julia, Carnathan, Diane G, Lingwood, Daniel, Burton, Dennis R, Alter, Galit, Padera, Timothy P, Belcher, Angela M, Schief, William R, Silvestri, Guido, Ruprecht, Ruth M, Crotty, Shane, Irvine, Darrell J
Published in Science immunology (03.12.2021)
Published in Science immunology (03.12.2021)
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Co-delivery of autoantigen and dexamethasone in incomplete Freund's adjuvant ameliorates experimental autoimmune encephalomyelitis
Northrup, Laura, Griffin, J. Daniel, Christopher, Matthew A., Antunez, Lorena R., Hartwell, Brittany L., Pickens, Chad J., Berkland, Cory
Published in Journal of controlled release (28.11.2017)
Published in Journal of controlled release (28.11.2017)
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Screening Immunomodulators To Skew the Antigen-Specific Autoimmune Response
Northrup, Laura, Sullivan, Bradley P, Hartwell, Brittany L, Garza, Aaron, Berkland, Cory
Published in Molecular pharmaceutics (03.01.2017)
Published in Molecular pharmaceutics (03.01.2017)
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Journal Article
Co-Delivery of Autoantigen and B7 Pathway Modulators Suppresses Experimental Autoimmune Encephalomyelitis
Northrup, Laura, Sestak, Joshua O., Sullivan, Bradley P., Thati, Sharadvi, Hartwell, Brittany L., Siahaan, Teruna J., Vines, Charlotte M., Berkland, Cory
Published in The AAPS journal (01.11.2014)
Published in The AAPS journal (01.11.2014)
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Journal Article
Molecular Dynamics of Multivalent Soluble Antigen Arrays Support a Two-Signal Co-delivery Mechanism in the Treatment of Experimental Autoimmune Encephalomyelitis
Hartwell, Brittany L, Smalter Hall, Aaron, Swafford, David, Sullivan, Bradley P, Garza, Aaron, Sestak, Joshua O, Northrup, Laura, Berkland, Cory
Published in Molecular pharmaceutics (01.02.2016)
Published in Molecular pharmaceutics (01.02.2016)
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Journal Article
Codelivery of antigen and an immune cell adhesion inhibitor is necessary for efficacy of soluble antigen arrays in experimental autoimmune encephalomyelitis
Sestak, Joshua O, Sullivan, Bradley P, Thati, Sharadvi, Northrup, Laura, Hartwell, Brittany, Antunez, Lorena, Forrest, M Laird, Vines, Charlotte M, Siahaan, Teruna J, Berkland, Cory
Published in Molecular therapy. Methods & clinical development (01.01.2014)
Published in Molecular therapy. Methods & clinical development (01.01.2014)
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Journal Article
Multivalent antigen arrays exhibit high avidity binding and modulation of B cell receptor-mediated signaling to drive efficacy against experimental autoimmune encephalomyelitis
Hartwell, Brittany L., Pickens, Chad J., Leon, Martin, Berkland, Cory
Published in Biomacromolecules (17.05.2017)
Published in Biomacromolecules (17.05.2017)
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Journal Article
Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters
Dalvie, Neil C, Rodriguez-Aponte, Sergio A, Hartwell, Brittany L, Tostanoski, Lisa H, Biedermann, Andrew M, Crowell, Laura E, Kaur, Kawaljit, Kumru, Ozan, Carter, Lauren, Yu, Jingyou, Chang, Aiquan, McMahan, Katherine, Courant, Thomas, Lebas, Celia, Lemnios, Ashley A, Rodrigues, Kristen A, Silva, Murillo, Johnston, Ryan S, Naranjo, Christopher A, Tracey, Mary Kate, Brady, Joseph R, Whittaker, Charles A, Yun, Dongsoo, Kar, Swagata, Porto, Maciel, Lok, Megan, Andersen, Hanne, Lewis, Mark G, Love, Kerry R, Camp, Danielle L, Silverman, Judith Maxwell, Kleanthous, Harry, Joshi, Sangeeta B, Volkin, David B, Dubois, Patrice M, Collin, Nicolas, King, Neil P, Barouch, Dan H, Irvine, Darrell J, Love, J Christopher
Published in bioRxiv (04.03.2021)
Published in bioRxiv (04.03.2021)
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Paper
Routes of Administration and Dose Optimization of Soluble Antigen Arrays in Mice with Experimental Autoimmune Encephalomyelitis
Thati, Sharadvi, Kuehl, Christopher, Hartwell, Brittany, Sestak, Joshua, Siahaan, Teruna, Laird Forrest, M., Berkland, Cory
Published in Journal of pharmaceutical sciences (01.02.2015)
Published in Journal of pharmaceutical sciences (01.02.2015)
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