Investigating the optimal size of anticancer nanomedicine
Tang, Li, Yang, Xujuan, Yin, Qian, Cai, Kaimin, Wang, Hua, Chaudhury, Isthier, Yao, Catherine, Zhou, Qin, Kwon, Mincheol, Hartman, James A., Dobrucki, Iwona T., Dobrucki, Lawrence W., Borst, Luke B., Lezmi, Stéphane, Helferich, William G., Ferguson, Andrew L., Fan, Timothy M., Cheng, Jianjun
Published in Proceedings of the National Academy of Sciences - PNAS (28.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (28.10.2014)
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Journal Article
Structural and Thermodynamic Model for the Activation of Cardiac Troponin
Poppe, Leszek, Hartman, James J, Romero, Antonio, Reagan, Jeffrey D
Published in Biochemistry (Easton) (19.04.2022)
Published in Biochemistry (Easton) (19.04.2022)
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Journal Article
Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle
Li, Monica X, Mercier, Pascal, Hartman, James J, Sykes, Brian D
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Journal Article
Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy
Chuang, Chihyuan, Collibee, Scott, Ashcraft, Luke, Wang, Wenyue, Vander Wal, Mark, Wang, Xiaolin, Hwee, Darren T, Wu, Yangsong, Wang, Jingying, Chin, Eva R, Cremin, Peadar, Zamora, Jeanelle, Hartman, James, Schaletzky, Julia, Wehri, Eddie, Robertson, Laura A, Malik, Fady I, Morgan, Bradley P
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Journal Article
Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure
Malik, Fady I., Hartman, James J., Elias, Kathleen A., Morgan, Bradley P., Rodriguez, Hector, Brejc, Katjuša, Anderson, Robert L., Sueoka, Sandra H., Lee, Kenneth H., Finer, Jeffrey T., Sakowicz, Roman, Baliga, Ramesh, Cox, David R., Garard, Marc, Godinez, Guillermo, Kawas, Raja, Kraynack, Erica, Lenzi, David, Lu, Pu Ping, Muci, Alexander, Niu, Congrong, Qian, Xiangping, Pierce, Daniel W., Pokrovskii, Maria, Suehiro, Ion, Sylvester, Sheila, Tochimoto, Todd, Valdez, Corey, Wang, Wenyue, Katori, Tatsuo, Kass, David A., Shen, You-Tang, Vatner, Stephen F., Morgans, David J.
Published in Science (American Association for the Advancement of Science) (18.03.2011)
Published in Science (American Association for the Advancement of Science) (18.03.2011)
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Journal Article
Supraphysiological levels of GDF11 induce striated muscle atrophy
Hammers, David W, Merscham‐Banda, Melissa, Hsiao, Jennifer Ying, Engst, Stefan, Hartman, James J, Sweeney, H Lee
Published in EMBO molecular medicine (01.04.2017)
Published in EMBO molecular medicine (01.04.2017)
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Journal Article
Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats
Collibee, Scott E., Romero, Antonio, Muci, Alexander R., Hwee, Darren T., Chuang, Chihyuan, Hartman, James J., Motani, Alykhan S., Ashcraft, Luke, DeRosier, Andre, Grillo, Mark, Lu, Qing, Malik, Fady I., Morgan, Bradley P.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Highly selective inhibition of myosin motors provides the basis of potential therapeutic application
Sirigu, Serena, Hartman, James J., Planelles-Herrero, Vicente José, Ropars, Virginie, Clancy, Sheila, Wang, Xi, Chuang, Grace, Qian, Xiangping, Lu, Pu-Ping, Barrett, Edward, Rudolph, Karin, Royer, Christopher, Morgan, Bradley P., Stura, Enrico A., Malik, Fady I., Houdusse, Anne M.
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2016)
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Journal Article
The small-molecule fast skeletal troponin activator, CK-2127107, improves exercise tolerance in a rat model of heart failure
Hwee, Darren T, Kennedy, Adam R, Hartman, James J, Ryans, Julie, Durham, Nickie, Malik, Fady I, Jasper, Jeffrey R
Published in The Journal of pharmacology and experimental therapeutics (01.04.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2015)
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Journal Article
Preclinical characterization of CK-4021586, a new class of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy
Sankar Sarkar, Saswata, Hartman, James J., Hwee, Darren T., Chuang, Chihyuan, Cremin, Peadar, deRosier, Andre, Edell, Samantha, Madhvani, Roshni, Wu, Yangsong, Yco, Lisette, Zamora, Jeanelle, Murphy, Anne, Morgan, Bradley P., Malik, Fady I.
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Journal Article
Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics
He, Huamei, Baka, Tomas, Balschi, James, Motani, Alykhan S, Nguyen, Kathy K, Liu, Qingxiang, Slater, Rebecca, Rock, Brooke, Wang, Chen, Hale, Christopher, Karamanlidis, Georgios, Hartman, James J, Malik, Fady I, Reagan, Jeff D, Luptak, Ivan
Published in Circulation. Heart failure (01.03.2022)
Published in Circulation. Heart failure (01.03.2022)
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Journal Article
Dietary soy isoflavones increase metastasis to lungs in an experimental model of breast cancer with bone micro-tumors
Yang, Xujuan, Belosay, Aashvini, Hartman, James A., Song, Huaxin, Zhang, Yukun, Wang, Wendan, Doerge, Daniel R., Helferich, William G.
Published in Clinical & experimental metastasis (01.04.2015)
Published in Clinical & experimental metastasis (01.04.2015)
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Journal Article
Dietary licorice root supplementation reduces diet‐induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland
Madak‐Erdogan, Zeynep, Gong, Ping, Zhao, Yiru Chen, Xu, Liwen, Wrobel, Kinga U, Hartman, James A, Wang, Michelle, Cam, Anthony, Iwaniec, Urszula T, Turner, Russell T, Twaddle, Nathan C, Doerge, Daniel R, Khan, Ikhlas A, Katzenellenbogen, John A, Katzenellenbogen, Benita S, Helferich, William G
Published in Molecular nutrition & food research (01.02.2016)
Published in Molecular nutrition & food research (01.02.2016)
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Journal Article
Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients
van den Berg, Marloes, Shi, Zhonghua, Claassen, Wout J, Hooijman, Pleuni, Lewis, Christopher T A, Andersen, Jesper L, van der Pijl, Robbert J, Bogaards, Sylvia J P, Conijn, Stefan, Peters, Eva L, Begthel, Leon P L, Uijterwijk, Bas, Lindqvist, Johan, Langlais, Paul R, Girbes, Armand R J, Stapel, Sandra, Granzier, Henk, Campbell, Kenneth S, Ma, Weikang, Irving, Thomas, Hwee, Darren T, Hartman, James J, Malik, Fady I, Paul, Marinus, Beishuizen, Albertus, Ochala, Julien, Heunks, Leo, Ottenheijm, Coen A C
Published in Science translational medicine (31.07.2024)
Published in Science translational medicine (31.07.2024)
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Journal Article
Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease
Donkervoort, Sandra, van de Locht, Martijn, Ronchi, Dario, Reunert, Janine, McLean, Catriona A, Zaki, Maha, Orbach, Rotem, de Winter, Josine M, Conijn, Stefan, Hoomoedt, Daan, Neto, Osorio Lopes Abath, Magri, Francesca, Viaene, Angela N, Foley, A Reghan, Gorokhova, Svetlana, Bolduc, Véronique, Hu, Ying, Acquaye, Nicole, Napoli, Laura, Park, Julien H, Immadisetty, Kalyan, Miles, Lee B, Essawi, Mona, McModie, Salar, Ferreira, Leonardo F, Zanotti, Simona, Neuhaus, Sarah B, Medne, Livija, ElBagoury, Nagham, Johnson, Kory R, Zhang, Yong, Laing, Nigel G, Davis, Mark R, Bryson-Richardson, Robert J, Hwee, Darren T, Hartman, James J, Malik, Fady I, Kekenes-Huskey, Peter M, Comi, Giacomo Pietro, Sharaf-Eldin, Wessam, Marquardt, Thorsten, Ravenscroft, Gianina, Bönnemann, Carsten G, Ottenheijm, Coen A C
Published in Science translational medicine (03.04.2024)
Published in Science translational medicine (03.04.2024)
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Journal Article
Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery
Huang, Guanyi, Bisaria, Anjali, Wakefield, Devin L., Yamawaki, Tracy M., Luo, Xin, Zhang, Jingli A., Vigneault, Patrick, Wang, Jinghong, Reagan, Jeffrey D., Oliverio, Oliver, Zhou, Hong, Li, Chi-Ming, Vila, Olaia F., Wang, Songli, Malik, Fady I., Hartman, James J., Hale, Christopher M.
Published in Stem cell reports (10.01.2023)
Published in Stem cell reports (10.01.2023)
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Journal Article
Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases
Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I
Published in Nature medicine (01.03.2012)
Published in Nature medicine (01.03.2012)
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