Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro³)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice
Irwin, N, McClean, P. L, O'Harte, F. P. M, Gault, V. A, Harriott, P, Flatt, P. R
Published in Diabetologia (01.07.2007)
Published in Diabetologia (01.07.2007)
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Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin
GAULT, V. A, O'HARTE, F. P. M, HARRIOTT, P, MOONEY, M. H, GREEN, B. D, FLATT, P. R
Published in Diabetologia (01.02.2003)
Published in Diabetologia (01.02.2003)
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N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity
Green, BD, Mooney, MH, Gault, VA, Irwin, N, Bailey, CJ, Harriott, P, Greer, B, O'Harte, FP, Flatt, PR
Published in Journal of endocrinology (01.03.2004)
Published in Journal of endocrinology (01.03.2004)
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Immunolocalization of protease‐activated receptor‐2 in skin: receptor activation stimulates interleukin‐8 secretion by keratinocytes in vitro
HOU, L., KAPAS, S., CRUCHLEY, A. T., MACEY, M. G., HARRIOTT, P., CHINNI, C., STONE, S. R., HOWELLS, G. L.
Published in Immunology (01.07.1998)
Published in Immunology (01.07.1998)
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Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3–42) and GLP-1(9–36)amide, on insulin secretion and glucose homeostasis in ob/ob mice
Parker, J C, Lavery, K S, Irwin, N, Green, B D, Greer, B, Harriott, P, O’Harte, F P M, Gault, V A, Flatt, P R
Published in Journal of endocrinology (01.10.2006)
Published in Journal of endocrinology (01.10.2006)
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Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
O'HARTE, F. P. M, GAULT, V. A, PARKER, J. C, HARRIOTT, P, MOONEY, M. H, BAILEY, C. J, FLATT, P. R
Published in Diabetologia (01.09.2002)
Published in Diabetologia (01.09.2002)
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Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues
Green, B. D., Gault, V. A., Mooney, M. H., Irwin, N., Harriott, P., Greer, B., Bailey, C. J., O'Harte, F. P. M., Flatt, P. R.
Published in Biological chemistry (01.02.2004)
Published in Biological chemistry (01.02.2004)
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Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo
Green, BD, Gault, VA, Mooney, MH, Irwin, N, Bailey, CJ, Harriott, P, Greer, B, Flatt, PR, O'Harte, FP
Published in Journal of molecular endocrinology (01.12.2003)
Published in Journal of molecular endocrinology (01.12.2003)
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Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid
Green, B D, Gault, V A, Flatt, P R, Harriott, P, Greer, B, O'Harte, F P M
Published in Archives of biochemistry and biophysics (15.08.2004)
Published in Archives of biochemistry and biophysics (15.08.2004)
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Cell-specific Processing of Chromogranin A in Endocrine Cells of the Rat Stomach
Norlen, Per, Curry, William J, Bjorkqvist, Maria, Maule, Aron, Cunningham, Rodat T, Hogg, Robert B, Harriott, Pat, Johnston, Colin F, Hutton, John C, Hakanson, Rolf
Published in The journal of histochemistry and cytochemistry (01.01.2001)
Published in The journal of histochemistry and cytochemistry (01.01.2001)
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Liver fluke ( Fasciola hepatica)-derived peptides activate rat peritoneal mast cells
Trudgett, A., Watt, A.P., Harriott, P., Ennis, M.
Published in International immunopharmacology (01.05.2003)
Published in International immunopharmacology (01.05.2003)
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