Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats
Harriman, Geraldine, Greenwood, Jeremy, Bhat, Sathesh, Huang, Xinyi, Wang, Ruiying, Paul, Debamita, Tong, Liang, Saha, Asish K., Westlin, William F., Kapeller, Rosana, Harwood, H. James
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
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Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma
Lally, James S.V., Ghoshal, Sarani, DePeralta, Danielle K., Moaven, Omeed, Wei, Lan, Masia, Ricard, Erstad, Derek J., Fujiwara, Naoto, Leong, Vivian, Houde, Vanessa P., Anagnostopoulos, Alexander E., Wang, Alice, Broadfield, Lindsay A., Ford, Rebecca J., Foster, Robert A., Bates, Jamie, Sun, Hailing, Wang, Ting, Liu, Henry, Ray, Adrian S., Saha, Asish K., Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Miao, Wenyan, Rocnik, Jennifer L., Westlin, William F., Muti, Paola, Tsakiridis, Theodoros, Harwood, H. James, Kapeller, Rosana, Hoshida, Yujin, Tanabe, Kenneth K., Steinberg, Gregory R., Fuchs, Bryan C.
Published in Cell metabolism (08.01.2019)
Published in Cell metabolism (08.01.2019)
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Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
Svensson, Robert U, Parker, Seth J, Eichner, Lillian J, Kolar, Matthew J, Wallace, Martina, Brun, Sonja N, Lombardo, Portia S, Van Nostrand, Jeanine L, Hutchins, Amanda, Vera, Lilliana, Gerken, Laurie, Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Westlin, William F, Harwood, H James, Saghatelian, Alan, Kapeller, Rosana, Metallo, Christian M, Shaw, Reuben J
Published in Nature medicine (01.10.2016)
Published in Nature medicine (01.10.2016)
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Journal Article
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279
Leit, Silvana, Greenwood, Jeremy, Carriero, Samantha, Mondal, Sayan, Abel, Robert, Ashwell, Mark, Blanchette, Heather, Boyles, Nicholas A., Cartwright, Mark, Collis, Alan, Feng, Shulu, Ghanakota, Phani, Harriman, Geraldine C., Hosagrahara, Vinayak, Kaila, Neelu, Kapeller, Rosanna, Rafi, Salma B., Romero, Donna L., Tarantino, Paul M., Timaniya, Jignesh, Toms, Angela V., Wester, Ronald T., Westlin, William, Srivastava, Bhaskar, Miao, Wenyan, Tummino, Peter, McElwee, Joshua J., Edmondson, Scott D., Masse, Craig E.
Published in Journal of medicinal chemistry (10.08.2023)
Published in Journal of medicinal chemistry (10.08.2023)
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Acetyl‐coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double‐blind, crossover study
Stiede, Kathryn, Miao, Wenyan, Blanchette, Heather S., Beysen, Carine, Harriman, Geraldine, Harwood, H. James, Kelley, Heather, Kapeller, Rosana, Schmalbach, Tess, Westlin, William F.
Published in Hepatology (Baltimore, Md.) (01.08.2017)
Published in Hepatology (Baltimore, Md.) (01.08.2017)
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Journal Article
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
Leit, Silvana, Greenwood, Jeremy R., Mondal, Sayan, Carriero, Samantha, Dahlgren, Markus, Harriman, Geraldine C., Kennedy-Smith, Joshua J., Kapeller, Rosana, Lawson, Jon P., Romero, Donna L., Toms, Angela V., Shelley, Mee, Wester, Ronald T., Westlin, William, McElwee, Joshua J., Miao, Wenyan, Edmondson, Scott D., Masse, Craig E.
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
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Journal Article
55 Exploring proximal biomarkers of CBL-B inhibition in human peripheral blood mononuclear cells
Greco, David, Qi, Yilin, Kuai, Jun, Jaeger, Samira, Bi, Yingzhi, Sun, Huadong, Liu, Wei, Carson, Ken, Reilly, Timothy, Harriman, Geraldine, Wang, Fang, Danaee, Hadi
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
864 Identification of a novel allosteric oral Cbl-b inhibitor that augmented T cell response and enhanced NK cell killing in vitro and in vivo
Kuai, Jun, Bi, Yingzhi, Qi, Yilin, Conrady, Deborah, Govindaraj, Rajiv, Hone, Graham, Aldrin Denny, R, Carson, Ken, Harriman, Geraldine, Wang, Fang
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Liver Selective Acetyl-CoA Carboxylase Inhibition Inhibits Hepatocellular Carcinoma in a Cirrhosis Model
DePeralta, Danielle K., MD, Wei, Lan, PhD, Harriman, Geraldine, PhD, Greenwood, Jeremy, Westlin, William F., PhD, Harwood, James, PhD, Bhat, Sathesh, Kapeller, Rosana, MD, PhD, Fuchs, Bryan C., PhD, Tanabe, Kenneth K., MD, FACS
Published in Journal of the American College of Surgeons (01.09.2014)
Published in Journal of the American College of Surgeons (01.09.2014)
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Journal Article
Selective cell adhesion inhibitors: Barbituric acid based α4β7—MAdCAM inhibitors
Harriman, Geraldine C., Brewer, Matthias, Bennett, Robert, Kuhn, Cyrille, Bazin, Marc, Larosa, Greg, Skerker, Paul, Cochran, Nancy, Gallant, Debra, Baxter, Deborah, Picarella, Dominic, Jaffee, Bruce, Luly, Jay R., Briskin, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.04.2008)
Published in Bioorganic & medicinal chemistry letters (01.04.2008)
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Journal Article
Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8
Jenkins, Tracy J, Guan, Bing, Dai, Mingshi, Li, Gang, Lightburn, Thomas E, Huang, Shan, Freeze, B. Scott, Burdi, Douglas F, Jacutin-Porte, Swanee, Bennett, Robert, Chen, Weirong, Minor, Charles, Ghosh, Shomir, Blackburn, Christopher, Gigstad, Kenneth M, Jones, Matthew, Kolbeck, Roland, Yin, Wei, Smith, Sean, Cardillo, Daniel, Ocain, Timothy D, Harriman, Geraldine C
Published in Journal of medicinal chemistry (08.02.2007)
Published in Journal of medicinal chemistry (08.02.2007)
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Journal Article
Selective cell adhesion inhibitors: Barbituric acid based alpha 4 beta 7 - MAdCAM inhibitors
Harriman, Geraldine C, Brewer, Matthias, Bennett, Robert, Kuhn, Cyrille, Bazin, Marc, Larosa, Greg, Skerker, Paul, Cochran, Nancy, Gallant, Debra, Baxter, Deborah, Picarella, Dominic, Jaffee, Bruce, Luly, Jay R, Briskin, Michael J
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Journal Article
Synthesis of 4-trifluoromethylpyrido[1,2- a]pyrimidin-2-ones utilizing activated alkynoates
Harriman, Geraldine C.B, Chi, Shannon, Zhang, Min, Crowe, Andrea, Bennett, Robert A, Parsons, Ian
Published in Tetrahedron letters (28.04.2003)
Published in Tetrahedron letters (28.04.2003)
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Journal Article
A Facile One-Flask Conversion of Aldehydes and Ketones to N-Sulfonyl Imines
Georg, Gunda I, Harriman, Geraldine C. B, Peterson, Scott A
Published in Journal of organic chemistry (01.11.1995)
Published in Journal of organic chemistry (01.11.1995)
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Journal Article
Accelerating drug discovery through tight integration of expert molecular design and predictive scoring
Abel, Robert, Mondal, Sayan, Masse, Craig, Greenwood, Jeremy, Harriman, Geraldine, Ashwell, Mark A, Bhat, Sathesh, Wester, Ronald, Frye, Leah, Kapeller, Rosana, Friesner, Richard A
Published in Current opinion in structural biology (01.04.2017)
Published in Current opinion in structural biology (01.04.2017)
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Journal Article
Synthesis of a Photoaffinity Taxol Analog and Its Use in Labeling Tubulin
Dasgupta, Debjani, Park, Haeil, Harriman, Geraldine C. B, Georg, Gunda I, Himes, Richard H
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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Journal Article
The Chemistry of the Taxane Diterpene: Stereoselective Reductions of Taxanes
Georg, Gunda I, Harriman, Geraldine C. B, Datta, Apurba, Ali, Syed, Cheruvallath, Zacharia, Dutta, Dinah, Vander Velde, David G, Himes, Richard H
Published in Journal of organic chemistry (27.11.1998)
Published in Journal of organic chemistry (27.11.1998)
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Abstract LB337: Inhibition of the E3 ligase CBL-B enhances the effector function and proliferation of natural killer cells
Qi, Yilin, Kuai, Jun, Bi, Yingzhi, Greco, David, Jaeger, Samira, Carson, Ken, Danaee, Hadi, Reilly, Timothy, Harriman, Geraldine, Wang, Fang
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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