Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
Meakin, Paul J, Harper, Alex J, Hamilton, D Lee, Gallagher, Jennifer, McNeilly, Alison D, Burgess, Laura A, Vaanholt, Lobke M, Bannon, Kirsten A, Latcham, Judy, Hussain, Ishrut, Speakman, John R, Howlett, David R, Ashford, Michael L J
Published in Biochemical journal (01.01.2012)
Published in Biochemical journal (01.01.2012)
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Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders
Bruns, Robert F., Mitchell, Stephen N., Wafford, Keith A., Harper, Alex J., Shanks, Elaine A., Carter, Guy, O'Neill, Michael J., Murray, Tracey K., Eastwood, Brian J., Schaus, John M., Beck, James P., Hao, Junliang, Witkin, Jeffrey M., Li, Xia, Chernet, Eyassu, Katner, Jason S., Wang, Hong, Ryder, John W., Masquelin, Meghane E., Thompson, Linda K., Love, Patrick L., Maren, Deanna L., Falcone, Julie F., Menezes, Michelle M., Zhang, Linli, Yang, Charles R., Svensson, Kjell A.
Published in Neuropharmacology (01.01.2018)
Published in Neuropharmacology (01.01.2018)
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Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
Davis, John B, Gray, Julie, Gunthorpe, Martin J, Hatcher, Jonathan P, Davey, Phil T, Overend, Philip, Harries, Mark H, Latcham, Judi, Clapham, Colin, Atkinson, Kirsty, Hughes, Stephen A, Rance, Kim, Grau, Evelyn, Harper, Alex J, Pugh, Perdita L, Rogers, Derek C, Bingham, Sharon, Randall, Andrew, Sheardown, Steven A
Published in Nature (London) (11.05.2000)
Published in Nature (London) (11.05.2000)
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BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes
Harrison, Steve M, Harper, Alex J, Hawkins, Julie, Duddy, Graham, Grau, Evelyn, Pugh, Pippa L, Winter, Panida H, Shilliam, Claire S, Hughes, Zoë A, Dawson, Lee A, Gonzalez, M Isabel, Upton, Neil, Pangalos, Menelas N, Dingwall, Colin
Published in Molecular and cellular neuroscience (01.11.2003)
Published in Molecular and cellular neuroscience (01.11.2003)
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Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons
Vinson, Mary, Rausch, Oliver, Maycox, Peter R, Prinjha, Rab K, Chapman, Debra, Morrow, Rachel, Harper, Alex J, Dingwall, Colin, Walsh, Frank S, Burbidge, Stephen A, Riddell, David R
Published in Molecular and cellular neuroscience (01.03.2003)
Published in Molecular and cellular neuroscience (01.03.2003)
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Targeted replacement of rodent CCR2 with the human orthologue CCR2B: A mouse model for in vivo analysis of human target-selective small molecule MCP-1 receptor antagonists
Prosser, Haydn M., Cooper, David G., Forbes, Ian T., Geppert, Martin, Gribble, Andrew D., Grau, Evelyn V., Groot, Pieter H., Harper, Alex J., Moores, Kitty E., Pickering, Susan J., Piercy, Valerie
Published in Drug development research (01.04.2002)
Published in Drug development research (01.04.2002)
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P1-018: BACE1 knockout mice fail to put on weight at the same rate as wild type control mice
Harper, Alex J., Latcham, Judy, Gonzalez, M. Isabel
Published in Alzheimer's & dementia (01.07.2006)
Published in Alzheimer's & dementia (01.07.2006)
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