Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy
Miller, Duncan C., Harnor, Suzannah J., Martin, Mathew P., Noble, Richard A., Wedge, Stephen R., Cano, Celine
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Advanced approaches of developing targeted covalent drugs
Gai, Conghao, Harnor, Suzannah J, Zhang, Shihao, Cano, Céline, Zhuang, Chunlin, Zhao, Qingjie
Published in MedChemComm (14.12.2022)
Published in MedChemComm (14.12.2022)
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Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines
Coxon, Christopher R, Anscombe, Elizabeth, Harnor, Suzannah J, Martin, Mathew P, Carbain, Benoit, Golding, Bernard T, Hardcastle, Ian R, Harlow, Lisa K, Korolchuk, Svitlana, Matheson, Christopher J, Newell, David R, Noble, Martin E. M, Sivaprakasam, Mangaleswaran, Tudhope, Susan J, Turner, David M, Wang, Lan Z, Wedge, Stephen R, Wong, Christopher, Griffin, Roger J, Endicott, Jane A, Cano, Céline
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Human Toxicity Caused by Indole and Indazole Carboxylate Synthetic Cannabinoid Receptor Agonists: From Horizon Scanning to Notification
Hill, Simon L, Dunn, Michael, Cano, Céline, Harnor, Suzannah J, Hardcastle, Ian R, Grundlingh, Johann, Dargan, Paul I, Wood, David M, Tucker, Simon, Bartram, Thomas, Thomas, Simon H L
Published in Clinical chemistry (Baltimore, Md.) (01.02.2018)
Published in Clinical chemistry (Baltimore, Md.) (01.02.2018)
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Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor
Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian, Harnor, Suzannah J., Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P., Martin, Nick C., Myers, Stephanie, Newell, David R., Noble, Richard A., Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A., Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
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Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge
Ford, Brian E., Chachra, Shruti S., Alshawi, Ahmed, Brennan, Alfie, Harnor, Suzannah, Cano, Celine, Baker, David J., Smith, David M., Fairclough, Rebecca J., Agius, Loranne
Published in Diabetes, obesity & metabolism (01.11.2020)
Published in Diabetes, obesity & metabolism (01.11.2020)
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An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase
Al-Khawaldeh, Islam, Al Yasiri, Mohammed J, Aldred, Gregory G, Basmadjian, Christine, Bordoni, Cinzia, Harnor, Suzannah J, Heptinstall, Amy B, Hobson, Stephen J, Jennings, Claire E, Khalifa, Shaimaa, Lebraud, Honorine, Martin, Mathew P, Miller, Duncan C, Shrives, Harry J, de Souza, João V, Stewart, Hannah L, Temple, Max, Thomas, Huw D, Totobenazara, Jane, Tucker, Julie A, Tudhope, Susan J, Wang, Lan Z, Bronowska, Agnieszka K, Cano, Céline, Endicott, Jane A, Golding, Bernard T, Hardcastle, Ian R, Hickson, Ian, Wedge, Stephen R, Willmore, Elaine, Noble, Martin E. M, Waring, Michael J
Published in Journal of medicinal chemistry (22.07.2021)
Published in Journal of medicinal chemistry (22.07.2021)
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Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation
Spry, Christina, Sewell, Alan L., Hering, Yuliya, Villa, Mathew V.J., Weber, Jonas, Hobson, Stephen J., Harnor, Suzannah J., Gul, Sheraz, Marquez, Rodolfo, Saliba, Kevin J.
Published in European journal of medicinal chemistry (01.01.2018)
Published in European journal of medicinal chemistry (01.01.2018)
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The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice
Haagensen, Emma J, Thomas, Huw D, Wilson, Ian, Harnor, Suzannah J, Payne, Sara L, Rennison, Tommy, Smith, Kate M, Maxwell, Ross J, Newell, David R
Published in PloS one (10.12.2013)
Published in PloS one (10.12.2013)
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Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4
Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Tucker, Julie A., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine
Published in European journal of medicinal chemistry (15.09.2019)
Published in European journal of medicinal chemistry (15.09.2019)
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2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase
Matheson, Christopher J, Coxon, Christopher R, Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M, Hardcastle, Ian R, Harnor, Suzannah J, Mas-Droux, Corine, Newell, David R, Richards, Mark W, Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J, Golding, Bernard T, Cano, Céline
Published in MedChemComm (01.06.2020)
Published in MedChemComm (01.06.2020)
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Concise syntheses of bridged morpholines
Zaytsev, Andrey V., Pickles, James E., Harnor, Suzannah J., Henderson, Alistair P., Alyasiri, Mohammed, Waddell, Paul G., Cano, Celine, Griffin, Roger J., Golding, Bernard T.
Published in RSC advances (01.01.2016)
Published in RSC advances (01.01.2016)
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Inhibition of the DNA-Dependent Protein Kinase for Cancer Therapy
Harnor, Suzannah J, Brennan, Alfie, Cano, Celine
Published in Medicinal chemistry (Sunnyvale, Calif.) (2017)
Published in Medicinal chemistry (Sunnyvale, Calif.) (2017)
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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction
Chessari, Gianni, Hardcastle, Ian R, Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H, Bevan, Luke D, Blackburn, Timothy J, Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J, Endicott, Jane A, Fazal, Lynsey, Golding, Bernard T, Griffin, Roger J, Haggerty, Karen, Harnor, Suzannah J, Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S, Howard, Steven, Jennings, Claire E, Johnson, Christopher N, Lunec, John, Miller, Duncan C, Newell, David R, Noble, Martin E. M, Reeks, Judith, Revill, Charlotte H, Riedinger, Christiane, St. Denis, Jeffrey D, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T, Vinković, Mladen, Wedge, Stephen R, Williams, Pamela A, Wilsher, Nicola E, Zhang, Bian, Zhao, Yan
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Abstract 5451: Profiling inhibitors of MDM2:p53 and MDMX:p53 in relation to MDMX protein levels
Tudhope, Sue, Zhao, Yan, Wittner, Anita, Wilmore, Elaine, Bertoli, Annalisa, Adhikari, Santosh, Harnor, Suzannah J., Bello, Fabio Del, Piergentili, Alessandro, Lunec, John, Hardcastle, Ian R., Griffin, Roger J., Golding, Bernard R., Cano, Celine, Newell, David R., Wedge, Stephen R.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase† †Electronic supplementary information (ESI) available: Kinase profiling, assay details, synthetic procedures and characterisation data for all compounds; including aniline precursors. All cell lines were supplied by the American Type Culture Collection, Manassas, Virginia, United States. All animal experiments performed were conducted under a UK Government Home Office License in accordance with relevant n
Matheson, Christopher J., Coxon, Christopher R., Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M., Hardcastle, Ian R., Harnor, Suzannah J., Mas-Droux, Corine, Newell, David R., Richards, Mark W., Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J., Golding, Bernard T., Cano, Céline
Published in RSC medicinal chemistry (22.05.2020)
Published in RSC medicinal chemistry (22.05.2020)
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Synthesis of 3′-deoxy-3′-fluorothymidine (FLT) 5′-O-glucuronide: a reference standard for imaging studies with [18F]FLTDRN conceived this study; BTG, SJH and DRN wrote the manuscript; SJH and TR performed the chemical synthesis supervised by CC, BTG and RJG; MG performed the HPLC analysis
Harnor, Suzannah J, Rennison, Tommy, Galler, Martin, Cano, Celine, Griffin, Roger J, Newell, David R, Golding, Bernard T
Year of Publication 24.06.2014
Year of Publication 24.06.2014
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Synthesis of 3′-deoxy-3′-fluorothymidine (FLT) 5′-O-glucuronide: a reference standard for imaging studies with [ 18 F]FLT
Harnor, Suzannah J., Rennison, Tommy, Galler, Martin, Cano, Celine, Griffin, Roger J., Newell, David R., Golding, Bernard T.
Published in MedChemComm (2014)
Published in MedChemComm (2014)
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